EARLY and DELAYED PHASES OF HIND PAW EDEMA IN RATS

Nakamura, Hideo; Shimizu, Masanao

doi:10.1254/jjp.24.393

Cited by 13 publications

(9 citation statements)

References 21 publications

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“…Even so, it is possible to highlight that paw edema model was the most used ( n = 10), followed by models of acute liver injury and asthma ( n = 4), and then, models of colitis, neuropathic pain, arthritis, ear edema, and hepatocarcinoma ( n = 3). Some of these models are concordant with findings in the literature, namely, the models of paw edema [ 69 , 70 , 71 , 72 , 73 , 74 ], ear edema [ 71 , 75 , 76 , 77 , 78 , 79 ], and arthritis [ 69 , 74 , 80 ].…”

Section: Resultssupporting

confidence: 85%

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

et al. 2022

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This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. Treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of Rosmarinus officinalis, and a dose of 10 mg/kg via IP of rosmarinic acid. Rosmarinus officinalis L. showed anti-inflammatory activity before and after induction of treatments.

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Section: Resultssupporting

confidence: 85%

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

et al. 2022

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“…The development of the oedema in the paw of the rat after the injection of carrageenan has been described as a biphasic event with different mediators for different phases (Swingle, 1974). The initial phase of the oedema has been attributed to the release of histamine and serotonin and the second phase to the release of prostaglandin-like substances (Nakamura and Shimizu, 1974). The results obtained suggest that the actions on histamine and serotonin shown by the MS-M extract could be responsible for the acute antiinflammatory activity shown in other species of the family Labiatae Phytother.…”

Section: Resultsmentioning

confidence: 83%

Pharmacological properties of the methanol extract fromMentha suaveolens Ehrh.

Moreno¹,

et al. 2002

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The present study analyses the pharmacological activity in in vivo and in vitro models of the methanol extract obtained from the leaves and steams of Menta suaveolens Ehrh. This extract lacked toxicity, but exhibited a central nervous system depressant action; an analgesic effect in models of chemical and mechanical stimulation suggesting the induction of a peripheral analgesic response. The extract also exhibited an antiinflammatory action inhibiting the rat paw oedema induced by carrageenin. Moreover, the in vitro studies showed a significant diminution in the contractile effects induced by histamine, serotonin and acetylcholine.

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“…These models can be used as secondary models to authorize the results of carrageenan-induced paw edema model, especially for those drugs that showed effect at the first phase of carrageenan-induced inflammation. These models are suitable for the assessment of those drugs that act through the histamine and/or 5-HT inhibition [163,164].…”

Section: Anti-inflammatory Drug Development From Natural Products:mentioning

confidence: 99%

Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals

Patil

Mahajan

Unger³

et al. 2019

IJMS

264

175

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Inflammation is one of the common events in the majority of acute as well as chronic debilitating diseases and represent a chief cause of morbidity in today’s era of modern lifestyle. If unchecked, inflammation leads to development of rheumatoid arthritis, diabetes, cancer, Alzheimer’s disease, and atherosclerosis along with pulmonary, autoimmune and cardiovascular diseases. Inflammation involves a complex network of many mediators, a variety of cells, and execution of multiple pathways. Current therapy for inflammatory diseases is limited to the steroidal and non-steroidal anti-inflammatory agents. The chronic use of these drugs is reported to cause severe adverse effects like gastrointestinal, cardiovascular, and renal abnormalities. There is a massive need to explore new anti-inflammatory agents with selective action and lesser toxicity. Plants and isolated phytoconstituents are promising and interesting sources of new anti-inflammatories. However, drug development from natural sources has been linked with hurdles like the complex nature of extracts, difficulties in isolation of pure phytoconstituents, and the yield of isolated compounds in minute quantities that is insufficient for subsequent lead development. Although various in-vivo and in-vitro models for anti-inflammatory drug development are available, judicious selection of appropriate animal models is a vital step in the early phase of drug development. Systematic evaluation of phytoconstituents can facilitate the identification and development of potential anti-inflammatory leads from natural sources. The present review describes various techniques of anti-inflammatory drug screening with its advantages and limitations, elaboration on biological targets of phytoconstituents in inflammation and biomarkers for the prediction of adverse effects of anti-inflammatory drugs. The systematic approach proposed through present article for anti-inflammatory drug screening can rationalize the identification of novel phytoconstituents at the initial stage of drug screening programs.

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EARLY and DELAYED PHASES OF HIND PAW EDEMA IN RATS

Cited by 13 publications

References 21 publications

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

Pharmacological properties of the methanol extract fromMentha suaveolens Ehrh.

Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals

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