1983
DOI: 10.1111/j.1471-4159.1983.tb11303.x
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Early and Dose‐Dependent Decrease of Retrograde Axonal Transport in Acrylamide‐Intoxicated Rats

Abstract: The effect of retrograde axonal transport of doses of acrylamide ranging from 50 to 500 mg/kg was studied in sensory nerve of rats. Accumulation of trichloroacetic acid-phosphotungstic acid-insoluble label was measured in a collection segment distal to a double ligature placed on the sciatic nerve at intervals 9-15 h and 9-24 h following injection into the dorsal root ganglion of the fifth lumbar root of [35S]methionine and [3H]fucose. After a dose of 100 mg/kg of acrylamide no neurological signs of neuropathy… Show more

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Cited by 73 publications
(17 citation statements)
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“…The present paper communicates the results obtained in the anterograde transport study; a recent report includes the findings from the study of the retrograde transport system (Jakobsen and Sidenius, 1983).…”
supporting
confidence: 66%
“…The present paper communicates the results obtained in the anterograde transport study; a recent report includes the findings from the study of the retrograde transport system (Jakobsen and Sidenius, 1983).…”
supporting
confidence: 66%
“…axonal transport (Jakobsen & Sidenius, 1983;Braendgaard & ter crush injury the mean ratio of ODC Logan & McLean, 1988). In the light of these r crushed nerve over that of uncrushed results, we propose that the impaired induction of ODC is a as 1.87 + 0.66 (s.d.…”
Section: Discussionmentioning
confidence: 84%
“…These changes represent the earliest alteration in nerve fiber integrity and precede by many days detectable morphologic alterations in peripheral nerve associated with repeated exposure to acrylamide. Tetanus toxin was selected as a marker of retrograde transport because, unlike other techniques for studying retrograde transport (Bisby and Bulgar, 1977;Sahenk and Mendel, 1981;Jakobsen and Sidenius, 1983), it does not require the use of nerve-fiber ligation or crush. The pathophysiologic state induced by these lesions may obscure, or alter, chemical-induced changes in retrograde transport.…”
Section: Discussionmentioning
confidence: 99%
“…Studies of fast and slow anterograde axonal transport in animals treated with acrylamide have revealed no marked changes (Bradley and Williams, 1973;Sumner et al, 1976;Griffin and Price, 1976;Sidenius and Jakobsen, 1983). Recent studies have demonstrated altered retrograde transport of horseradish peroxidase (Kemplay and Cavanagh, 1983) and of materials which have "turned around" following fast anterograde axonal transport in animals repeatedly dosed With acrylamide that demonstrate signs of neuropathy (Sahenk and Mendell, 1981;Jakobsen and Sidenius, 1983). It is, however, unclear from these studies whether alterations in retrograde axonal transport precede, or occur secondary to, the onset of axonal degeneration.…”
mentioning
confidence: 99%