Early and Late Complications after a Nonabsorbable Hydrogel Polymer Injection: A Series of 14 Patients and Novel Management

Goldan, Oren; Georgiou, Ioannis; Grabov-Nardini, Gil; Regev, Eli; Tessone, Ariel; Liran, Alon; Haik, Josef; Mendes, David G.; Orenstein, Arie; Winkler, Eyal

doi:10.1111/j.1524-4725.2007.33361.x

Cited by 21 publications

(20 citation statements)

References 7 publications

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“…[270][271][272][273][274][275][276][277][278] Complications secondary to the injections of Bio-Alcamid include edema (Fig 30), bruising, and nodules and, in particular, infections. [279][280][281][282][283][284][285][286] To our knowledge, no granulomas secondary to Bio-Alcamid have been described. There are few histopathologic studies describing the findings in the local reactions to Bio-Alcamid, and the microscopic study of the material obtained from an indurated nodule has shown basophilic amorphous material corresponding to the implanted material, surrounded by epithelioid histiocytes, foreign body multinucleated giant cells, neutrophils and red cells 281 (Fig 31).…”

Section: Poly-l-lactic Acid Key Pointsmentioning

confidence: 80%

Adverse reactions to injectable soft tissue fillers

Requena

Christensen

et al. 2011

Journal of the American Academy of Dermatology

288

237

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Section: Poly-l-lactic Acid Key Pointsmentioning

confidence: 80%

Adverse reactions to injectable soft tissue fillers

Requena

Christensen

et al. 2011

Journal of the American Academy of Dermatology

288

237

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“…Interestingly, many of the recovered bacteria are not considered human pathogens. Other authors have also obtained bacteria from cultures of the material from drainage of inflammatory nodules [25,26,27,28,29]. In these reported cases, Staphylococcus aureus, Streptococcus spp.…”

Section: Discussionmentioning

confidence: 93%

Are Bacterial Growth and/or Chemotaxis Increased by Filler Injections? Implications for the Pathogenesis and Treatment of Filler-Related Granulomas

et al. 2010

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Background: As microbial agents have been associated with late adverse effects related to fillers antibiotic treatment has been envisaged. Objective: To determine whether biomaterials favor bacterial growth and/or attract bacteria. Methods: Hyaluronic acid, semi-permanent fillers, such as calcium hydroxylapatite, and permanent fillers, such as polyalkylimide/polyacrylamide, were used. Experiments were performed with Escherichia coli, strain HVH-U47. Bacteria were transferred to Sven-Gard agar to test mobility. Striae of this bacterial strain with a MacFarland 1 turbulence pattern were seeded from a spot of inoculated biomaterial using Müller-Hinton medium. The chemoattractive properties of the biomaterials were analyzed 10 days after inoculation. Bacterial growth over the biomaterial and in-depth growth were assessed as well. Results: Semi-permanent fillers did not stimulate bacterial growth but they allowed bacterial colonization over the filler. Permanent acrylic compounds neither presented chemoattractant properties nor showed bacterial growth over the biomaterial. Similar results were obtained when performing in-depth cultures. Conclusions: Permanent and semi-permanent fillers did not facilitate bacterial growth when flagellated E. coli HVH-U47 was used. Our results do not argue in favor of antibiotics as the mainstay of therapy in late granulomas related to permanent fillers. In the case of resorbable/semi-permanent fillers, more studies are needed before recommending antibiotic therapy.

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“…Infections of Bio-Alcamid injections are extremely difficult to treat. They usually require high-dose antibiotics plus incision, drainage and irrigation [80][81][82].…”

Section: Risks Of Permanent Fillersmentioning

confidence: 99%

Risks of permanent fillers

Haneke¹

2009

Expert Review of Dermatology

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Early and Late Complications after a Nonabsorbable Hydrogel Polymer Injection: A Series of 14 Patients and Novel Management

Cited by 21 publications

References 7 publications

Adverse reactions to injectable soft tissue fillers

Adverse reactions to injectable soft tissue fillers

Are Bacterial Growth and/or Chemotaxis Increased by Filler Injections? Implications for the Pathogenesis and Treatment of Filler-Related Granulomas

Risks of permanent fillers

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