Early and late effects of hyperbaric oxygen treatment on oxidative stress parameters in diabetic patients

Gürdöl, Figen; Çimşit, Maide; Öner-İyidoğan, Yıldız; Körpınar, Şefika; Yalçınkaya, Şükrü; Koçak, Harun

doi:10.33549/physiolres.931139

Cited by 26 publications

(6 citation statements)

References 34 publications

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“…Reactive oxygen species (including superoxide-ion and hydrogen peroxide) [33-41] [33,37,38,42,43] [33,42-44] Nitric oxide synthase (NOS) (including endothelial NOS and inducible NOS) [34,[45][46][47][48] [ [49][50][51] [ [52][53][54] Reactive nitrogen species (including nitric oxygen, nitrite and nitrate) [33,34,45,49 Advanced oxidation protein products [77] Carbohydrate peroxidation…”

Section: Associated Markers Stimulating Effect No Effect Inhibiting Effectmentioning

confidence: 99%

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

et al. 2021

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Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inflammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inflammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the first HBOT session or for a short duration after each session. The anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-κB and IκBα. Further research into the effect of HBOT on inflammation and angiogenesis is needed to determine the implications of these findings for clinical practice.

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Section: Associated Markers Stimulating Effect No Effect Inhibiting Effectmentioning

confidence: 99%

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

et al. 2021

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“…These reactive species interact with transcription factors, increase endothelial dysfunction and dysregulate enzymatic activity, leading to vascular inflammation [ 101 ]. Diabetic patients receiving HBOT show increased level of lipid oxidation after the first treatment, yet after the 15th treatment, these patients returned to basal level (before the first treatment) [ 102 ]. The authors hypothesized that this effect could be explained by increased activation of antioxidant enzymes.…”

Section: Disease and Oxidative Stressmentioning

confidence: 99%

Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress

2021

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Hyperbaric oxygen treatment (HBOT)—the administration of 100% oxygen at atmospheric pressure (ATA) greater than 1 ATA—increases the proportion of dissolved oxygen in the blood five- to twenty-fold. This increase in accessible oxygen places the mitochondrion—the organelle that consumes most of the oxygen that we breathe—at the epicenter of HBOT’s effects. As the mitochondrion is also a major site for the production of reactive oxygen species (ROS), it is possible that HBOT will increase also oxidative stress. Depending on the conditions of the HBO treatment (duration, pressure, umber of treatments), short-term treatments have been shown to have deleterious effects on both mitochondrial activity and production of ROS. Long-term treatment, on the other hand, improves mitochondrial activity and leads to a decrease in ROS levels, partially due to the effects of HBOT, which increases antioxidant defense mechanisms. Many diseases and conditions are characterized by mitochondrial dysfunction and imbalance between ROS and antioxidant scavengers, suggesting potential therapeutic intervention for HBOT. In the present review, we will present current views on the effects of HBOT on mitochondrial function and oxidative stress, the interplay between them and the implications for several diseases.

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“…19,20 Moreover, the study underscored the safety and feasibility of HBOT, corroborating the comprehensive safety profiles documented in previous research. 21,22 While this study meticulously unfolds the multifaceted benefits of HBOT, it is pertinent to acknowledge its limitations and potential areas for improvement. The absence of a control group slightly moderates the conclusiveness of our findings, rendering this study as a pivotal but nondefinitive contribution to the existing pool of knowledge.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 Moreover, the study underscored the safety and feasibility of HBOT, corroborating the comprehensive safety profiles documented in previous research. 21,22…”

Section: Discussionmentioning

confidence: 99%

Outcome of Chronic Foot Osteomyelitis Treated With Hyperbaric Oxygen: An Observational Study

Menekse

2023

The International Journal of Lower Extremity Wounds

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Chronic refractory osteomyelitis of the foot stands as a formidable challenge in medical care, associated with significant morbidity and escalating healthcare costs. Traditional therapeutic approaches, including surgical debridement and systemic antibiotics, often fall short, leaving patients and clinicians in search of more efficacious interventions. Hyperbaric oxygen therapy (HBOT), an innovative therapeutic modality, has recently emerged as a promising adjunct therapy, offering a beacon of hope in this therapeutic conundrum. In this groundbreaking observational study, we meticulously analyzed the experiences of 80 patients suffering from chronic refractory osteomyelitis of the foot. Following surgical debridement and tailored antibiotic therapy, each patient was treated with HBOT at 2.5 atmospheres absolute for 120 min, 5 days a week, spanning an average of 50 days. Our primary endpoints focused on complete eradication of infection, recurrence metrics, and any adverse effects linked to HBOT. Astonishingly, 68 of the 80 patients (85%) achieved a total infection clearance, maintaining this status through a mean follow-up period of 36 months, all without a single report of HBOT-induced complications. Our compelling findings advocate that HBOT, synergized with standard surgical and antibiotic regimens, can revolutionize the treatment landscape for chronic refractory osteomyelitis of the foot. Given these promising preliminary results, there's an imperative need for extensive research to delineate the long-term advantages and to fine-tune HBOT protocols, potentially paving the way for a new therapeutic gold standard.

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Early and late effects of hyperbaric oxygen treatment on oxidative stress parameters in diabetic patients

Cited by 26 publications

References 34 publications

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress

Outcome of Chronic Foot Osteomyelitis Treated With Hyperbaric Oxygen: An Observational Study

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