Early and late effects of daily treatment with pregnant mare serum upon the ovary of mice of the A strain

Pfeiffer, Carl J.; Hooker, Charles W.

doi:10.1002/ar.1090840402

Cited by 13 publications

(2 citation statements)

References 13 publications

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“…Mice injected daily from birth with serum gonadotrophin showed no evidence of follicle stimulation during the first 12 days (Pfeiffer Sc Hooker 1942), while in rats a response to gonadotrophin injection from day 4 to 10 resulted in 'increased mitosis in the theca and granulosa leading to slight fol¬ licular enlargement' (Price Se Ortiz 1944). The question whether gonado¬ trophins are necessary for follicle development in the infant mouse ovary has recently been reinvestigated (Eshkol et al, in prep.).…”

Section: Follicle Growthmentioning

confidence: 99%

The Development of the Mouse Ovary From Birth to Maturity

Peters¹

1969

Acta Endocrinologica

311

184

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Changes occur in the infant ovary which develop the structurally simple organ at birth to a highly complex one in the maturing animal. The ovary in the immature mouse is not a dormant organ but one that is characterized by a continuous growth and development and a concurrent continuous degeneration of oocytes and follicles. The stroma cells which are present in the ovary at birth are apparently a pool of cells with multiple potentialities, which contribute to the development of the earliest granulosa and theca cells. The interfollicular stroma of the juvenile ovary, however, originates from collapsing and contracting follicles. The quantitative changes in the oocyte and follicle population during the immature period lead to a marked reduction in the total number of oocytes and a simultaneous numerical increase in follicles at different stages of development. Factors influencing oocyte atresia and follicle development in the immature mouse are discussed.In the time interval between birth and maturity the ovary develops from a uniform fairly simple organ to a multiform, highly differentiated one. During the infant and juvenile period the ovary is not a dormant organ, but one in which constant growth, differentiation and degeneration occur.The ovary at birth consists mainly of 2 types of cells: 1) the highly specia¬ lized oocytes and 2) the multipotential 'stroma' cells; multipotential, because it must be from this pool of morphologically undistinguished cells that later granulosa cells, theca cells, lutein cells and others arise. In the time interval of about 5 weeks -between birth and beginning maturity -the ovary does not only grow in size but undergoes a remarkable development that leads among other things to the formation of complicated bodies like large follicles which

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Section: Follicle Growthmentioning

confidence: 99%

The Development of the Mouse Ovary From Birth to Maturity

Peters¹

1969

Acta Endocrinologica

311

184

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“…It is tempting to speculate that adrenergic nerves may play a role in the proliferation of follicles during the postnatal and prepubertal stages when gonadotropins are very low [Donovan et al, 1975a, b]. Support for this suggestion is provided by the finding that exogenous gonadotropins do not increase the number of growing follicles in newborn mice [Pfeiffer and Hooker, 1942;Peters et al, 1973]. It should be noted, however, that nerves are not seen in close apposition to all developing follicles, and hence it is doubtful that the adrenergic innervation is the controlling factor for folliculogenesis during this period.…”

Section: Discussionmentioning

confidence: 99%

The Adrenergic Innervation of the Guinea Pig Ovary During Prenatal and Postnatal Periods

Burden¹,

Lawrence²,

Louis³

1985

Cells Tissues Organs

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The pattern of adrenergic nerves was visualized and norepinephrine (NE) quantified in guinea pig ovaries from fetal day 50 to term and on days 1, 5, 10, 20 and 28 postnatally. Before birth, there were a few perivascular adrenergic nerves and correspondingly low ovarian NE levels. After birth and through day 20, nerves gradually grew into adjacent stroma. By day 28, there was a proliferation of beaded adrenergic nerves around blood vessels and into adjacent stroma, which was reflected by significantly increased ovarian levels of NE. These findings are discussed in relation to antral follicle development, atresia, and interstitial gland formation in the ovaries of prepubertal guinea pigs.

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Some Studies on Ovarian Tumorigenesis

Gardner

2008

Novartis Foundation Symposia

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Early and late effects of daily treatment with pregnant mare serum upon the ovary of mice of the A strain

Cited by 13 publications

References 13 publications

The Development of the Mouse Ovary From Birth to Maturity

The Development of the Mouse Ovary From Birth to Maturity

The Adrenergic Innervation of the Guinea Pig Ovary During Prenatal and Postnatal Periods

Some Studies on Ovarian Tumorigenesis

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