Early and Late Effects of Breast-Feeding: Does Breast-Feeding Really Matter?

Villalpando, Salvador; Hamosh, Margit

doi:10.1159/000014022

Cited by 50 publications

(29 citation statements)

References 90 publications

(141 reference statements)

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“…A protective effect of breast-feeding on lymphoma was reported in other studies (Davis et al, 1988;Shu et al, 1995), but the effect was not significant for leukaemia (Davis et al, 1988;Magnani et al, 1988;Shu et al, 1995). Some of the components of breast milk actively stimulate the immune system and promote its development, increasing the capacity of children to face immune challenge (Hasselbalch et al, 1996;Hanson, 1998;Villalpando and Hamosh, 1998). This supports the immunological model proposed by Greaves (1997) and the present results.…”

Section: Discussionsupporting

confidence: 89%

Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia

2000

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Summary Infections are suspected to play a role in the aetiology of childhood leukaemia. In 1989-95, we evaluated the relation between childhood acute lymphoblastic leukaemia and pre-and postnatal markers of exposure to infection, as well as breast-feeding. A populationbased case-control study was carried out in certain regions of Québec, Canada, in 1989-95 including 491 incident cases diagnosed between 1980 and 1993 and aged between 0 and 9 years. An identical number of healthy controls matched for age, sex and region of residence at the date of diagnosis was included. Having older siblings, mother's use of antibiotics during pregnancy, and being born second or later were all associated with increased risk of leukaemia while early day-care attendance (odds ratio (OR) = 0.49; 95% CI 0.31-0.77), and breastfeeding (OR = 0.68; 95% CI 0.49-0.95) were significantly protective. A marker of population mixing was not a risk factor. When including all variables defining family structure in a model, having older siblings at time of diagnosis was a risk factor among children diagnosed before 4 years of age (OR = 4.54; 95% CI 2.27-9.07) whereas having older siblings in the first year of life was protective among children diagnosed at 4 years of age or later (OR = 0.46; 95% CI 0.22-0.97).

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Section: Discussionsupporting

confidence: 89%

Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia

2000

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“…Several case -control studies found a negative correlation between frequency and duration of breast-feeding and type 1 diabetes (Schrezenmeir & Jagla, 2000;Villalpando & Hamosh, 1998). This beneficial action has been attributed to reduced exposure to diabetogenic agents (especially viruses).…”

Section: Lcpufas and Type 1 Diabetesmentioning

confidence: 99%

Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent diabetes mellitus?

Das¹

2003

Eur J Clin Nutr

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It is suggested that the negative correlation between breast-feeding and insulin resistance and diabetes mellitus can be related to the presence of significant amounts of long-chain polyunsaturated fatty acids in the human breast milk. Based on this, it is proposed that provision of adequate amounts of long chain polyunsaturated fatty acids during the critical periods of brain growth and development can prevent or postpone the development diabetes mellitus.

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“…The major components in formula milk are similar to breast milk, but breast milk contains many additional factors (Villapando & Hamosh, 1998;Bernt & Walker, 1999), and is the best form of nutrition for the infant. Currently, there is little information on the levels of lutein and zeaxanthin in human milk and none in formula milk.…”

Section: Introductionmentioning

confidence: 99%

A comparison of lutein and zeaxanthin concentrations in formula and human milk samples from Northern Ireland mothers

et al. 2003

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Background: Two carotenoids, lutein and zeaxanthin are found in the retinal pigment epithelium of the eye where they are believed to protect it against oxidative and light damage. The amounts of these carotenoids consumed by premature infants are not known. Objective: The objective of the investigation was to measure these carotenoids in human and formulae milks. Design: In all, 28 human milk samples were obtained at various times between days 1 and 41 of lactation from 13 mothers. Six formula milks commonly used in hospitals were also analysed. Setting: Mothers who provided the milk samples had infants in the neonatal ward at the Royal Maternity Hospital, Belfast. Results: Median lutein and zeaxanthin concentrations in human milk were 4.79 (range 0.42-9.98) nmol/g fat and 0.55 (0.00-1.70) nmol/g fat, respectively. Five of the six formula milks also contained lutein and zeaxanthin with concentrations that varied over a wide range (0.7-9.7 and 0.1-1.2 nmol/g fat, respectively). Conclusions: Carotenoid concentrations usually decreased with the duration of lactation. Some formula milks that were specially formulated for premature infants contained high concentrations of the lutein and zeaxanthin and the source may be egg yolk. Sponsorship: These studies were supported by the University of Ulster and the Northern Ireland Mother and Baby Appeal.

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Early and Late Effects of Breast-Feeding: Does Breast-Feeding Really Matter?

Cited by 50 publications

References 90 publications

Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia

Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia

Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent diabetes mellitus?

A comparison of lutein and zeaxanthin concentrations in formula and human milk samples from Northern Ireland mothers

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