Early and late onset depression in young and middle aged adults: Differential symptomatology, characteristics and risk factors?

Korten, Nicole; Comijs, Hannie C.; Lamers, Femke; Penninx, Brenda W. J. H.

doi:10.1016/j.jad.2012.01.042

Cited by 109 publications

(93 citation statements)

References 39 publications

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“…In the current analysis mood instability was coded from a personality trait assessment and therefore having this temperamental trait may mean that individuals are more likely to develop depression and PTSD. The potential pathway may be through the strong association between mood instability and neuroticism which itself is a risk factor for depression [32,33].…”

Section: Discussionmentioning

confidence: 99%

Mood instability, mental illness and suicidal ideas: results from a household survey

Marwaha

Parsons

Broome

2013

Soc Psychiatry Psychiatr Epidemiol

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Purpose: There is weak and inconsistent evidence that mood instability (MI) is associated with depression, PTSD and suicidality although the basis of this is unclear. Our objectives were first to test whether there is an association between depression and PTSD, and MI and secondly whether MI exerts an independent effect on suicidal thinking over and above that explained by common mental disorders. Methods: We used data from the Adult Psychiatric Morbidity Survey 2007 (N=7131). Chi-square tests were used to examine associations between depression and PTSD, and MI, followed by regression modelling to examine associations between MI and depression, and with PTSD. Multiple logistic regression analyses were used to assess the independent effect of MI on suicidal thinking, after adjustment for demographic factors and the effects of common mental disorder diagnoses.Results: There are high rates of MI in depression and PTSD and the presence of MI increases the odds of depression by 10.66 (95% CI 7.51-15.13) and PTSD by 8.69 (95% CI 5.90-12.79) respectively, after adjusting for other factors. Mood instability independently explained suicidal thinking, multiplying the odds by nearly five (OR 4.82; 95% CI 3.39-6.85), and was individually by some way the most important single factor in explaining suicidal thoughts.Conclusions: MI is strongly associated with depression and PTSD. In people with common mental disorders MI is clinically significant as it acts as an additional factor exacerbating the risk of suicidal thinking. It is important to enquire about MI as part of clinical assessment and treatment studies are required.

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Section: Discussionmentioning

confidence: 99%

Mood instability, mental illness and suicidal ideas: results from a household survey

Marwaha

Parsons

Broome

2013

Soc Psychiatry Psychiatr Epidemiol

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“…For sensitivity analyses we defined a minor depressive episode as the presence of at least 1 core symptom and 1-3 other symptoms of depression, and we defined early-onset depression as onset of MDD before the age of 40 years. 22 Depressive symptoms were assessed using a validated Dutch version of the 9-item Patient Health Questionnaire (PHQ-9). 23 The PHQ-9 is a self-administered questionnaire based on the DSM-IV 21 criteria for MDD.…”

Section: Assessment Of Depressionmentioning

confidence: 99%

Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study

Onete

Henry

Sep

et al. 2018

jpn

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“…In people with BPD, prospective studies show that it is the strongest factor in the diagnostic criteria for that disorder that predicts suicidal behaviour and more so than a negative mood state overall (Yen et al, 2004). Neuroticism (Korten et al, 2012) and having more interpersonal difficulties with partners are both linked to AI as well as future depression (Miller andPilkonis, 2006, Thompson et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Neurobiological and behavioural studies of affective instability in clinical populations: A systematic review

Broome

Iftikhar

et al. 2015

Neuroscience & Biobehavioral Reviews

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Early and late onset depression in young and middle aged adults: Differential symptomatology, characteristics and risk factors?

Cited by 109 publications

References 39 publications

Mood instability, mental illness and suicidal ideas: results from a household survey

Mood instability, mental illness and suicidal ideas: results from a household survey

Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study

Neurobiological and behavioural studies of affective instability in clinical populations: A systematic review

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