Early and late postpartum depression exhibit distinct correlates: the IGEDEPP prospective cohort study

Tebeka, Sarah; Strat, Yann Le; Mandelbrot, Laurent; Benachi, Alexandra; Dommergues, Marc; Kayem, Gilles; Lepercq, J.; Luton, Dominique; Ville, Y.; Ramoz, Nicolas; Mullaert, Jimmy; Dubertret, Caroline

doi:10.22541/au.159188592.22056384

Cited by 3 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In case of MDE history, the perinatal context was assessed by a question: "Did this episode occur during or following a previous pregnancy?" PPD corresponded to having experienced a PPD between birth and 1 year postpartum: we pooled women with early-onset PPD, assessed during the second interview (at 8 weeks postpartum), and those with late-onset PPD, assessed during the third one (at 1 year postpartum), using DSM-5 diagnostic criteria of MDE [29,30].…”

Section: Assessmentsmentioning

confidence: 99%

Major depressive episode and postpartum depression: A network analysis comparison on the IGEDEPP cohort

et al. 2023

Self Cite

View full text Add to dashboard Cite

Introduction Major depression episode (MDE) and postpartum depression (PPD) have the same diagnosis criteria, but dissimilarities may be present regarding the frequency and structure of depressive symptoms. Methods We used data from the IGEDEPP Cohort (France) to examine DSM-5 depressive symptoms in two groups of women: 486 with PPD and 871 with a history of non-perinatal MDE. We compare (i) the frequency of each depressive symptom adjusted for the severity of depression, (ii) the global structure of depressive symptom networks, and (iii) the centrality of each symptom in the two networks. Results Women with PPD were significantly more likely to have appetite disturbance, psychomotor symptoms, and fatigue than those with MDE, while sadness, anhedonia, sleep disturbance, and suicidal ideation were significantly less common. There were no significant differences in the global structure of depressive symptoms of MDE and PPD. However, the most central criterion of the MDE network was “Sadness” while it was “Suicidal ideations” for the PPD network. “Sleep” and “Suicidal ideations” criteria were more central for PPD network, whereas “Culpability” was more important for MDE network than for PPD network. Conclusion We found differences in depressive symptoms expression between PPD and MDE, which justify continuing to clinically distinguish PPD from MDE.

show abstract

Section: Assessmentsmentioning

confidence: 99%

Major depressive episode and postpartum depression: A network analysis comparison on the IGEDEPP cohort

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…This disorder is a complex multifactorial disease with sociodemographic, environmental, psychiatric, and genetic determinants [ 1 , 14 , 15 ]. We have previously shown that sociodemographic, clinical, and environmental determinants of early- and late-onset PPD are different, suggesting partially overlapping pathophysiological mechanisms [ 15 , 16 ]. However, in both types of PPD, personal and family histories of depression are important risk factors for PPD, suggesting a genetic vulnerability.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study

TEBEKA,

GLOAGUEN,

MULLAERT

et al. 2024

Eur. Psychiatr.

Self Cite

View full text Add to dashboard Cite

Postpartum depression (PPD) appears at two peak periods: early-onset prior to 2 months after delivery and late-onset (2 months after delivery and beyond). The aim of our study is to evaluate the different genetic factors associated with early- and late-onset PPD. With the French multicenter interaction of gene and environment of depression during postpartum (IGEDEPP) cohort, we conducted a genome-wide association study (GWAS) on 234 women with early-onset PPD and 223 women with late-onset PPD, as well as 1,204 controls with no history of lifetime depression. We performed post-GWAS analyses: functional mapping and annotation of GWAS results using MAGMA thanks to Functional Mapping and Annotation of Genome-Wide Association Studies (FUMA), expression quantitative trait loci (QTL) analyses, mapping using data from the PsychENCODE and GTEx, and polygenic risk score (PRS) analysis based on published GWAS. We found two new significant candidate loci for early-onset PPD, rs6436132 in PTPRN gene on chromosome 2 and rs184644645 in RAD18 on chromosome 14, respectively, and one region of interest with five significant associated SNPs in chromosome 20 for late-onset PPD. Variant rs6436132 is the most significant associated with early-onset PPD, and it is a QTL that significantly modifies the expression and splicing of the PTPRN gene in different brain tissues. We also found an enrichment of uterus tissue in the early expression of PPD genes. PRS analysis showed a genetic overlap between both early and late-onset PPD and major depressive disorder, but only early-onset PPD overlaps with bipolar disorder. Our study presents two GWAS separately, highlighting two candidate loci for early-onset PPD and one different region of interest for late-onset PPD. These results have important consequences in our understanding of these disorders, especially since our data reinforce the hormonal pathophysiological hypotheses for early-onset PPD.

show abstract

Predictors of postnatal depression in the slums Nairobi, Kenya: a cross-sectional study

et al. 2022

View full text Add to dashboard Cite

Background Postnatal depression (PND) is a universal mental health problem that prevents mothers’ optimal existence and mothering. Although research has shown high PND prevalence rates in Africa, including Kenya, little research has been conducted to determine the contributing factors, especially in low-resource communities. Objective This study aimed to investigate the PND risk factors among mothers attending Lang’ata and Riruta Maternal and Child Health Clinics (MCH) in the slums, Nairobi. Methods This study was cross-sectional. It is part of a large study that investigated the effectiveness of a brief psychoeducational intervention on PND. Postnatal mothers (567) of 6-10 weeks postanatal formed the study population. Depression rate was measured using the original 1961 Beck’s Depression Inventory (BDI). In addition, a sociodemographic questionnaire (SDQ) was used to collect hypothesized risk variables. Multivariable logistic regression analysis was used to explore predictors of PND. Results The overall prevalence of PND in the sample of women was 27.1%. Women aged 18-24 (β = 2.04 95% C.I.[0.02; 4.05], p = 0.047), dissatisfied with body image (β = 4.33 95% C.I.[2.26; 6.41], p < 0.001), had an unplanned pregnancy (β = 2.31 95% C.I.[0.81; 3.80], p = 0.003 and felt fatigued (β = − 1.85 95% C.I.[− 3.50; 0.20], p = 0.028) had higher odds of developing PND. Participants who had no stressful life events had significantly lower depression scores as compared to those who had stressful life events (β = − 1.71 95% C.I.[− 3.30; − 0.11], p = 0.036) when depression was treated as a continuous outcome. Sensitivity analysis showed that mothers who had secondary and tertiary level of education had 51 and 73% had lower likelihood of having depression as compared to those with a primary level of education (A.O.R = 0.49 95% C.I.[0.31-0.78], p = 0.002) and (A.O.R = 0.27 95% C.I.[0.09-0.75], p = 0.013) respectively. Conclusion This study reveals key predictors/risk factors for PND in low-income settings building upon the scanty data. Identifying risk factors for PND may help in devising focused preventive and treatment strategies.

show abstract

Early and late postpartum depression exhibit distinct correlates: the IGEDEPP prospective cohort study

Cited by 3 publications

References 42 publications

Major depressive episode and postpartum depression: A network analysis comparison on the IGEDEPP cohort

Major depressive episode and postpartum depression: A network analysis comparison on the IGEDEPP cohort

Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study

Predictors of postnatal depression in the slums Nairobi, Kenya: a cross-sectional study

Contact Info

Product

Resources

About