Early and late seizures after cryptogenic ischemic stroke in young adults

Lamy, Catherine; Domigo, Valérie; Semah, Franck; Arquizan, Caroline; Trystram, Denis; Coste, Joël; Mas, Jean‐Louis

doi:10.1212/wnl.60.3.400

Cited by 244 publications

(255 citation statements)

References 41 publications

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“…The average age of vascular epilepsy occurrence established at 53 years in our study population is similar to that observed in the literature, and it reflects the age pyramid in our country. In fact, cerebrovascular injuries account for 30% to 50% of epilepsies among elderly individuals [3]. Unlike the female predominance observed in Szaflarski series [12], we recorded no such prevalence in our population.…”

Section: Discussioncontrasting

confidence: 69%

“…The association of these two pathologies is not haphazard. Indeed, epilepsy is one of the most common stroke comorbidities [3]. Stroke accounts for 11% of adult symptomatic epilepsies [4], and beyond the age of 60, it is the leading cause of epilepsy (33%) ahead of degenerative diseases including Alzheimer's disease (15%), brain tumors (5%) or brain trauma injury (1% to 2%) [5].…”

Section: Introductionmentioning

confidence: 99%

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Post-Stroke Epilepsy within a Teaching Hospital in Cotonou, Benin

Gnonlonfoun¹,

Adjien²,

Agbétou³

et al. 2017

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Seizures occurring after stroke are risk factors for the onset of ensuing epilepsy. However, the incidence of vascular epilepsy is low. The purpose of this study was to study vascular epilepsy features in a teaching university. It was a retrospective, descriptive and analytical study, conducted from 1 st January 2015 to 31 st December 2016 in Cotonou Teaching Hospital (CNHU-HKM), Benin. It involved 35 patients brought together through comprehensive sampling. Vascular epilepsy hospital attendance rate was 2%. There were simple partial seizures in 74.28% of cases while cerebral ischemia was recorded in 44.44% of patients. Neurological consultation after stroke occurrence was a protective factor against the occurrence of vascular epilepsy with significant p at 0.001.

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Section: Discussioncontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Post-Stroke Epilepsy within a Teaching Hospital in Cotonou, Benin

Gnonlonfoun¹,

Adjien²,

Agbétou³

et al. 2017

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“…We observed that 4.6% of our patients had an episode of seizures within 24 hours of onset of stroke. Camilo et al [10], found that the estimates of early post ischemic stroke seizures were as 2% while Lamy et al [11], observed seizures in 2.4% of 581 cryptogenic stroke patients within the first 24 hours. Dhanuka et al [9], observed that the incidence of post-stroke epilepsy in India was 13%.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of diabetes mellitus in ischemic stroke patients was observed to be having significant association with the manifestation of seizures in our study. Approximately 50% to 90% of early onset seizures appear to be simple partial seizures [2,11,13,14]. Various studies revealed simple partial seizures as the most common type (61%) in patients with early onset seizures [12,14,15].…”

Section: Discussionmentioning

confidence: 99%

Frequency and Outcomes of Early Onset Seizures after Ischemic Stroke

Natuva¹,

Khaseem²,

Padala³

et al. 2015

J Neurol Exp Neurosci

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“…In the literature, stroke severity was found to be a predictor of clinical poststroke seizures in some studies, [21][22][23][24] but not all. 25 Recent elec- trophysiologic studies using cEEG in patients admitted to an intensive care unit 7,8 did not find stroke severity to be a predictor of electrical epileptic seizures.…”

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confidence: 99%

Pergolide-induced ergotism

Morgan

Sethi²

2006

Neurology

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Abstract-Objective: To determine the incidence and risk factors of electrical seizures and other electrical epileptic activity using continuous EEG (cEEG) in patients with acute stroke. Methods: One hundred consecutive patients with acute stroke admitted to our stroke unit underwent cEEG using 10 electrodes. In addition to electrical seizures, repetitive focal sharp waves (RSHWs), repetitive focal spikes (RSPs), and periodic lateralized epileptic discharges (PLEDs) were recorded. Results: In the 100 patients, cEEG was recorded for a mean duration of 17 hours 34 minutes (range 1 hour 12 minutes to 37 hours 10 minutes). Epileptic activity occurred in 17 patients and consisted of RSHWs in seven, RSPs in seven, and PLEDs in three. Electrical seizures occurred in two patients. On univariate Cox regression analysis, predictors for electrical epileptic activity were stroke severity (high score on the National Institutes of Health Stroke Scale) (hazard ratio [HR] 1.12; p ϭ 0.002), cortical involvement (HR 5.71; p ϭ 0.021), and thrombolysis (HR 3.27; p ϭ 0.040). Age, sex, stroke type, use of EEG-modifying medication, and cardiovascular risk factors were not predictors of electrical epileptic activity. On multivariate analysis, stroke severity was the only independent predictor (HR 1.09; p ϭ 0.016). Conclusion: In patients with acute stroke, electrical epileptic activity occurs more frequently than previously suspected. NEUROLOGY 2006;67:99-104 Patients with acute stroke treated in a stroke unit show a relative reduction in mortality.1 Recent guidelines 2-4 have put forward recommendations for the organization of stroke units and defined the usefulness of several acute diagnostic tests, including brain CT and MRI, laboratory examinations, duplex and transcranial ultrasonography, and monitoring of blood pressure, EKG, oxygen saturation, and body temperature. These guidelines also provide strategies for the treatment of acute stroke, including general care and specific therapies, such as recanalization or prevention of complications.However, the role of continuous EEG (cEEG) monitoring in the stroke unit has not been adequately assessed, despite the high incidence of clinical seizures, which ranges from 2 to 33% in the acute phase of stroke, 5 and the potentially harmful effect of seizures on acute ischemic tissue. 6 The information regarding the usefulness of cEEG in acute stroke was obtained in studies on severe stroke patients admitted to intensive care units. Electrical seizures were detected in 9 to 15% of patients, depending on patient selection and the cEEG technique. [7][8][9] In this study, we sought to determine the incidence and risk factors of electrical seizure and epileptic electrical activity in acute stroke patients admitted to our stroke unit.Methods. Subject selection. We prospectively recruited 100 consecutive patients admitted to our stroke unit. Inclusion criteria were acute symptoms and signs consistent with ischemic or hemorrhagic stroke. Exclusion criteria were subarachnoid or posttraumatic hemorr...

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Early and late seizures after cryptogenic ischemic stroke in young adults

Abstract: Epilepsy is rarely a major problem in young cryptogenic ischemic stroke survivors. Early seizures are associated with stroke disability and cortical involvement. Early seizures, cortical signs, and large infarct are independent risk factors for late seizures.

Cited by 244 publications

References 41 publications

Post-Stroke Epilepsy within a Teaching Hospital in Cotonou, Benin

Post-Stroke Epilepsy within a Teaching Hospital in Cotonou, Benin

Frequency and Outcomes of Early Onset Seizures after Ischemic Stroke

Pergolide-induced ergotism

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