Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Vansteenkiste, Johan; Ruysscher, Dirk De; Eberhardt, Wilfried; Lim, Eric; Senan, Suresh; Felip, Enriqueta; Peters, Solange

doi:10.1093/annonc/mdt241

Cited by 449 publications

(375 citation statements)

References 58 publications

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“…Despite SBRT being usually a well-tolerated treatment, it was not comparable to surgery in different studies (25,26). The European Society for medical oncology clinical guidelines consider SBRT as a first-line treatment in non-operable patients (27). Haasbeek et al demonstrated an improvement in overall survival in the surgical and radiotherapy groups compared to the patients without treatment (25).…”

Section: Discussionmentioning

confidence: 99%

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Curative resection for lung cancer in octogenarians is justified

Tutic-Horn

Gambazzi

Rocco³

et al. 2017

J. Thorac. Dis.

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Background: Due to an increased life expectancy in a healthy aging population and a progressive incidence of lung cancer, curative pulmonary resections can be performed even in octogenarians. The present study aims to investigate whether surgery is justified in patients reaching the age of 80 years and older who undergo resection for non-small cell lung cancer (NSCLC). . The overall 90-day mortality was 1.1%. The median hospitalisation and chest drainage times were 10 days (range, 5-27 days) and 5 days (range, 0-17 days), respectively. Thirty-six patients were complication-free (41%). In particular, pulmonary complications occurred in 25 patients (28%). In addition, 23 patients (26%) developed cardiovascular complications requiring medical intervention, while 24 patients (27%) had cerebrovascular complications, urinary tract infection and others. The median survival time was 51 months (range, 1-110 months), and the 5-year overall survival reached 45% without significance between tumour stages. Conclusions: Curative lung resections in selected octogenarians can be safely performed up to pneumonectomy for all tumour stages with a perioperative mortality, morbidity, and 5-year survival rate comparable to younger cohorts.

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Section: Discussionmentioning

confidence: 99%

“…If possible, a pre-treatment pathological proof, preferably obtained by biopsy, is recommended. If this is not possible and if malignancy is highly likely based on the described criteria, immediate SBRT without histopathological confirmation could be a treatment option (27).…”

Section: Discussionmentioning

confidence: 99%

Curative resection for lung cancer in octogenarians is justified

Tutic-Horn

Gambazzi

Rocco³

et al. 2017

J. Thorac. Dis.

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show abstract

“…According to international guidelines [6, [18][19][20], concurrent platinum-based chemotherapy and thoracic irradiation is the recommended treatment for locally advanced inoperable NSCLC. This recommendation is based on the results of a series of randomized studies and meta-analyses demonstrating the superiority of concurrent chemo-radiation over radiotherapy alone [21,22] and over sequential chemo-radiation [23][24][25][26] at the cost, however, of an increased toxicity [3].…”

Section: Discussionmentioning

confidence: 99%

Randomized phase III PITCAP trial and meta-analysis of induction chemotherapy followed by thoracic irradiation with or without concurrent taxane-based chemotherapy in locally advanced NSCLC

et al. 2016

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“…Given the better local control rates, the treatment of choice for stage I NSCLC is considered to be either open or video-assisted thoracic surgery [88]. However, in the case of patients with early-stage NSCLC and severely impaired lung function, a local ablative therapy (SBRT or RFA) can be considered [89].…”

Section: Nsclcmentioning

confidence: 99%