Early and mid-term results of isolated aortic valve neocuspidization in patients with aortic stenosis

Iida, Yasunori; Fujii, Satoshi; Akiyama, Sho; Sawa, Shigeharu

doi:10.1007/s11748-018-0976-0

Cited by 27 publications

(26 citation statements)

References 15 publications

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“…This is in line with recently published first data from the United Kingdom (UK) with peak and mean transvalvular gradients of 16 ± 3.7 and 9 ± 2.2 mmHg after 12.5 months [13•]. In patients with isolated aortic stenosis, Iida and colleagues report a mean peak pressure gradient of 22 ± 10.7 mmHg one week after the procedure and 19.2 ± 9.7 mmHg after 20 months [8]. In our cohort, after median 21 months of followup, median (IQR) mean and peak gradients were 6 (5,9) mmHg and 12 (8, 17) mmHg, respectively; these results are similar to recently published data from a US center [12].…”

Section: Hemodynamicsupporting

confidence: 86%

“…Moderate aortic regurgitation was seen in two patients (7%). Median (IQR) mean gradient was 6 (5,9) mmHg, and median (IQR) peak gradient was 12 (8,17) mmHg [14•].…”

Section: Durabilitymentioning

confidence: 99%

“…Notwithstanding, the aortic valve replacement (AVR) technique with autologous glutaraldehyde-treated pericardium to rebuild the aortic valve, the so called "OZAKI" procedure (also referred to as "aortic valve neocuspidization, AVNeo"), has gained popularity within the past years [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. The concept of using (autologous) pericardium to reconstruct/rebuild the aortic valve is well known in pediatric cardiac surgery.…”

Section: Introductionmentioning

confidence: 99%

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Aortic Valve Neocuspidization Using Autologous Pericardium (Ozaki Procedure): an Alternative to Aortic Valve Replacement in Adult Cardiac Surgery?

Koechlin

Eckstein

2021

Curr Anesthesiol Rep

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Purpose of the Review The aim of this article is to describe the technique of aortic valve neocuspidization using autologous pericardium (AVNeo, “OZAKI procedure”) in adult cardiac surgery, to analyze recent findings, and to discuss benefits and limitations of this technique. Recent Findings Potential benefits of this technique include excellent hemodynamic performances, minimal use of foreign material, low rates of permanent pacemaker implantation, and omission of oral anticoagulation. However, data regarding the durability of the procedure are hitherto limited, and the procedure is associated with a higher complexity compared to aortic valve replacement. Summary AVNeo using autologous pericardium in adult cardiac surgery is a promising technique providing several benefits. However, there is a major unmet need for more data, especially regarding long-term durability. Thus, based on currently available data, we recommend careful patient selection within the heart team and shared decision-making with the informed patient.

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Section: Hemodynamicsupporting

confidence: 86%

“…Moderate aortic regurgitation was seen in two patients (7%). Median (IQR) mean gradient was 6 (5,9) mmHg, and median (IQR) peak gradient was 12 (8,17) mmHg [14•].…”

Section: Durabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aortic Valve Neocuspidization Using Autologous Pericardium (Ozaki Procedure): an Alternative to Aortic Valve Replacement in Adult Cardiac Surgery?

Koechlin

Eckstein

2021

Curr Anesthesiol Rep

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“…Iida et al [7] performed AVNeo for aortic stenosis in 57 patients from December 2010 to June 2017. Their mean age was 77.5±8.8 years.…”

Section: Resultsmentioning

confidence: 99%

Aortic Valve Neocuspidization with Glutaraldehyde-Treated Autologous Pericardium (Ozaki Procedure) – A Promising Surgical Technique

Sá

Perazzo

Zhigalov

et al. 2019

Braz J Cardiovasc Surg

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In cases of aortic valve disease, prosthetic valves have been increasingly used for valve replacement, however, there are inherent problems with prostheses, and their quality in the so-called Third World countries is lower in comparison to new-generation models, which leads to shorter durability. Recently, transcatheter aortic valve replacement has been explored as a less invasive option for patients with high-risk surgical profile.In this scenario, aortic valve neocuspidization (AVNeo) has emerged as another option, which can be applied to a wide spectrum of aortic valve diseases. Despite the promising results, this procedure is not widely spread among cardiac surgeons yet. Spurred on by the last publications, we went on to write an overview of the current practice of state-of-the-art AVNeo and its results.

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“…(8) Similar results were reported by several other centres suggesting this procedure are reproducible across different centres and surgical teams. (9)(10)(11) Krane et al demonstrated the effectiveness of this technique in a younger population and compared the haemodynamic performance with virtually implanted Trifecta Bioprostheses. They reported a significantly lower mean pressure gradient as well as a higher mean effective orifice area in AV Neo.…”

Section: Clinical Outcome Of Av Neomentioning

confidence: 99%

Aortic Valve Neocuspidization using glutaraldehyde-treated autologous pericardium: A literature review

Chan

Basu

discenza

et al. 2020

Preprint

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Background: Aortic Valve Neocuspidization using glutaraldehyde-treated autologous pericardium was first performed by Ozaki et al. in 2007. This technique has become an alternative to tissue and mechanical valve as long-term anticoagulation is not required and shows promising midterm results and durability. Method: A comprehensive search was performed on the major database using search terms “Ozaki technique” AND “Aortic Valve Neocuspidization” AND “AV Neocuspidization” AND “Autologous pericardium” AND “glutaraldehyde-treated autologous pericardium”. Articles up to 1st of August 2020 were included in this study. Results: A total of 9 studies with a total of 1342 patients were included. The mean age was 67.36 and 54.23% were male. 66.32% and 23.92% of patients had aortic stenosis and aortic regurgitation, respectively. 66% of patients had a native tricuspid aortic valve and 31.37 % patients’ native aortic valve was bicuspid. Three studies reported their experience performing Aortic Valve Neocuspidization via mini sternotomy. Conclusion: Aortic Valve Neocuspidization is an alternative to biological and mechanical prostheses for surgical aortic valve replacement. The short and mid-term outcome are comparable without the need for long term oral anticoagulation. Long term follow-up data is required for this novel approach to be widely adopted.

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Early and mid-term results of isolated aortic valve neocuspidization in patients with aortic stenosis

Abstract: AVNeo is suitable for patients with AS considering its early and mid-term outcomes. Verification of long-term outcomes and reliability is necessary.

Cited by 27 publications

References 15 publications

Aortic Valve Neocuspidization Using Autologous Pericardium (Ozaki Procedure): an Alternative to Aortic Valve Replacement in Adult Cardiac Surgery?

Aortic Valve Neocuspidization Using Autologous Pericardium (Ozaki Procedure): an Alternative to Aortic Valve Replacement in Adult Cardiac Surgery?

Aortic Valve Neocuspidization with Glutaraldehyde-Treated Autologous Pericardium (Ozaki Procedure) – A Promising Surgical Technique

Aortic Valve Neocuspidization using glutaraldehyde-treated autologous pericardium: A literature review

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