Early and Midterm Outcomes of Endovascular Treatment in Arterial Manifestations of Vascular Behcet Disease

İşcan, Hakkı Zafer; Yiğit, Görkem; Çetinkaya, Ferit; Erdoğan, Kemal; Tümer, Naım Boran; Özen, Anıl; Mavioğlu, Levent; Ünal, Ertekin Utku

doi:10.1016/j.avsg.2022.12.074

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…• More data are needed to understand the role of biologics other than TNF-α inhibitors and JAK inhibitors in BS (101-107). • Pre-and post-intervention immunosuppressive treatment improves the outcome of BS undergoing endovascular repair of arterial complications (108)(109)(110).…”

Section: Take Home Messagesmentioning

confidence: 99%

Behçet's yndrome: one year in review 2023

Hatemi,

Seyahi,

Fresko

et al. 2023

Clinical and Experimental Rheumatology

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Section: Take Home Messagesmentioning

confidence: 99%

Behçet's yndrome: one year in review 2023

Hatemi,

Seyahi,

Fresko

et al. 2023

Clinical and Experimental Rheumatology

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“…Fortunately, endovascular therapy with proper medicines for the treatment of AAA in patients with BD has yielded promising results with low morbidity and mortality. 4,5 Therefore, early diagnosis and treatment of AAA in patients with BD are of utmost importance to prevent the rupture of AAA. Biomarkers can facilitate timely detection and medical intervention for conditions such as BD and asymptomatic AAA, which typically lack discernible clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…AAA is characterised by progressive aortic dilation that may result in a potentially lethal rupture. Fortunately, endovascular therapy with proper medicines for the treatment of AAA in patients with BD has yielded promising results with low morbidity and mortality 4,5 . Therefore, early diagnosis and treatment of AAA in patients with BD are of utmost importance to prevent the rupture of AAA.…”

Section: Introductionmentioning

confidence: 99%

Identification of biomarkers for abdominal aortic aneurysm in Behçet's disease via mendelian randomization and integrated bioinformatics analyses

Liu,

Wu,

et al. 2024

J Cellular Molecular Medi

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Behçet's disease (BD) is a complex autoimmune disorder impacting several organ systems. Although the involvement of abdominal aortic aneurysm (AAA) in BD is rare, it can be associated with severe consequences. In the present study, we identified diagnostic biomarkers in patients with BD having AAA. Mendelian randomization (MR) analysis was initially used to explore the potential causal association between BD and AAA. The Limma package, WGCNA, PPI and machine learning algorithms were employed to identify potential diagnostic genes. A receiver operating characteristic curve (ROC) for the nomogram was constructed to ascertain the diagnostic value of AAA in patients with BD. Finally, immune cell infiltration analyses and single‐sample gene set enrichment analysis (ssGSEA) were conducted. The MR analysis indicated a suggestive association between BD and the risk of AAA (odds ratio [OR]: 1.0384, 95% confidence interval [CI]: 1.0081–1.0696, p = 0.0126). Three hub genes (CD247, CD2 and CCR7) were identified using the integrated bioinformatics analyses, which were subsequently utilised to construct a nomogram (area under the curve [AUC]: 0.982, 95% CI: 0.944–1.000). Finally, the immune cell infiltration assay revealed that dysregulation immune cells were positively correlated with the three hub genes. Our MR analyses revealed a higher susceptibility of patients with BD to AAA. We used a systematic approach to identify three potential hub genes (CD247, CD2 and CCR7) and developed a nomogram to assist in the diagnosis of AAA among patients with BD. In addition, immune cell infiltration analysis indicated the dysregulation in immune cell proportions.

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