Early and subacute inflammatory response and long-term survival after hip trauma and surgery

Sedlář, Martin; Kvasnička, Jan; Krška, Z; Tománková, Tereza; Linhart, Aleš

doi:10.1016/j.archger.2015.02.002

Cited by 24 publications

(15 citation statements)

References 21 publications

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“…Inflammatory changes induced by hip trauma and surgery can affect survival. [10] It has been suggested that acute inflamma-tory response assessed by some inflammatory markers, such as tumor necrosis factor-∝ (TNF-∝), interleukin-6 (IL-6), and IL-10 can predict the 12-month outcome of patients with hip fracture. [11] NLR is also described as a new potential marker of systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Admission Neutrophile to Lymphocyte Ratio and Postoperative Mortality in Elderly Hip Fracture Patients

Temiz

Эрсозлу²

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Hip fractures in elderly patients are associated with a high mortality rate. Most deaths associated with hip fracture result from complications after surgery. Recent studies suggest that the neutrophil-to-lymphocyte ratio (NLR), which is a laboratory marker used to evaluate systemic inflammation, may be useful to estimate excess mortality. This study aimed to investigate the prognostic value of admission NLR in elderly patients with hip fracture. METHODS: We evaluated patients admitted to the Orthopaedic Surgery Department of Balikesir-Edremit State Hospital. Inclusion criteria were female gender, age between 65 and 80 years, ASA score of 3, unstable intertrochanteric fracture treated with hemiarthroplasty, and time between fracture and surgery less than 72 h. Patients with multiple fracture, previous same side or other side hip surgery, pathological fracture, such as fracture caused by tumor or metabolic bone disease (e.g., Paget's disease), and malignancies were excluded from this study (purposive sampling technique). Finally, "case" (group 1) was defined as patients who died within 1 year after surgery, whereas "control" (group 2) was defined as patients who survived. Patients in group 1 and 2 were statistically compared in terms of NLR value on hospital admission. A total of 22 patients (44%) were included in group 1, and 28 (56%) were included in group 2. RESULTS: We found that the admission NLR values of patients in the mortality group were significantly higher than those of patients in the control group (p<0.001). The cutoff value of NLR was calculated as 4.7 on ROC analysis. CONCLUSION: We believe that the NLR value at admission could be used for risk stratification of mortality in elderly patients with hip fracture.

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Section: Discussionmentioning

confidence: 99%

Admission Neutrophile to Lymphocyte Ratio and Postoperative Mortality in Elderly Hip Fracture Patients

Temiz

Эрсозлу²

2018

Ulus Travma Acil Cerrahi Derg

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“…In previous studies, a number of factors in hip fractures that could lead to mortality have been analyzed. However, there are a limited studies show that the subtypes of leukocyte and thrombocyte counts, especially NL and PL, are associated with severe clinical conditions and mortality in major surgical procedures in the literature (10)(11)(12). In this study, we aimed to determine the prognostic value of the NLR and PLR on one-year mortality in patients who have hip fractures and aged over 60 years.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of the Neutrophil–Lymphocyte and Platelet– Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years

Emektar¹,

Çorbacıoğlu²,

Dağar³

et al. 2017

EAJEM

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“…NLR has recently emerged as a prognostic marker in patients with cancer, coronary artery diseases and ischemic cerebrovascular diseases and has been reported to be an indicator of the overall inflammatory status of the body [12-15] and it has recently been begun to be studied in the orthopedics field. After surgery for hip fracture it was found to be related with postoperative mortality [16,17]. This marker has not yet been studied in patients with PJI.…”

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confidence: 99%

Neutrophil to Lymphocyte Ratio May Be a Diagnostic Marker for Prosthetic Joint Infection

2016

Ann Clin Anal Med

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Early and subacute inflammatory response and long-term survival after hip trauma and surgery

Cited by 24 publications

References 21 publications

Admission Neutrophile to Lymphocyte Ratio and Postoperative Mortality in Elderly Hip Fracture Patients

Admission Neutrophile to Lymphocyte Ratio and Postoperative Mortality in Elderly Hip Fracture Patients

Prognostic Value of the Neutrophil–Lymphocyte and Platelet– Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years

Neutrophil to Lymphocyte Ratio May Be a Diagnostic Marker for Prosthetic Joint Infection

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