Early Antimicrobial Evaluation of Nanostructured Surfaces Based on Bacterial Biological Properties

Abstract

Nanostructured physical antibacterial surfaces are of great interest due to the increasing antibiotic resistance. In this work, the titania nanotube (TNT) array, a potential physical antibacterial surface, was used for antimicrobial evaluation. The early antibacterial properties of TNTs were assessed based on three growth phases of Staphylococcus aureus (S. aureus), and the physical factors influencing the antibacterial properties were comprehensively discussed. The results show apparent early antibacterial effects of TNTs, including the anti-initial attachment during the lag phase, the inhibition of proliferation and bactericidal effect during the logarithmic phase, and the inhibition of biofilm formation during the stationary phase. These antimicrobial effects are closely related to the combined influence of various physical properties of TNTs, such as diameter, hydrophilicity, roughness, and charge. The present work suggests that the evaluation of the early antimicrobial behavior of biomaterials should pay more attention on the biological characteristics of bacteria.

Nature‐Skin‐Derived e‐Skin as Versatile “Wound Therapy‐Health Monitoring” Bioelectronic Skin‐Scaffolds: Skin to Bio‐e‐Skin

“…The protrusions on the surface of the microspheres will bring a better copper ion release effect [ 35 ] and kill bacteria by physical means. [ 36 ] Herein, by integrating the inherent advantageous high‐performances of natural ADM and the antibacterial activity of cicada wing, a novel ADM‐based bioelectronic skin (e‐ADM, also referred to as bio‐e‐skin) was fabricated to obtain versatile “wound therapy‐health monitoring” tissue‐nanoengineered skin‐scaffolds. The “one‐pot” bio‐compositing strategy of nature ADM was used to incorporate the functional building blocks of conductive carbon nanotubes (CNTs) and self‐assembled micro‐copper oxide microspheres with a cicada‐wing‐like rough surface and nanocone microstructure.…”