Early Aspirin Therapy May Reduce Hepatic Artery Thrombosis in Liver Transplantation

Shay, Rebecca; Taber, David J.; Pilch, Nicole A.; Meadows, Holly B.; Tischer, Sarah; McGillicuddy, John W.; Bratton, C. B.; Baliga, P.; Chavin, Kenneth D.

doi:10.1016/j.transproceed.2012.05.075

Cited by 57 publications

(51 citation statements)

References 12 publications

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“…Aspirin therapy has been reported to reduce hepatic artery thrombosis, one of the leading causes of early liver graft loss [Shay et al, ]. In addition, this NSAID was the first pharmacological agent shown to induce HSR in cells exposed at various time points at 42°C [Jurivich et al, , ].…”

Section: Discussionmentioning

confidence: 99%

Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells

Miova

Dinevska-Ќovkarovska

Esplugues

et al. 2015

J of Cellular Biochemistry

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Registro de acceso restringido Este recurso no está disponible en acceso abierto por política de la editorial. No obstante, se puede acceder al texto completo desde la Universitat Jaume I o si el usuario cuenta con suscripción. Registre d'accés restringit Aquest recurs no està disponible en accés obert per política de l'editorial. No obstant això, es pot accedir al text complet des de la Universitat Jaume I o si l'usuari compta amb subscripció. Restricted access item This item isn't open access because of publisher's policy. The full--text version is only available from Jaume I University or if the user has a running suscription to the publisher's contents.

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Section: Discussionmentioning

confidence: 99%

Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells

Miova

Dinevska-Ќovkarovska

Esplugues

et al. 2015

J of Cellular Biochemistry

View full text Add to dashboard Cite

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“…In this series, the differences in significant surgical bleeding (in this study defined as needing >2 U packed red cells) or bowel perforation between the ASA and the non-ASA groups were not statistically significant. 37 Similarly, Vivarelli et al reported significantly lower incidence of late HAT with use of aspirin prophylaxis post-OLT (0.4%, 1 of 236 on ASA vs 2.2% 13 of 592 no ASA, P ¼ .049). 38 The above-selected representative examples illustrate our premise that thromboprophylactic anticoagulation in selected high-risk OLT scenarios may be considered carefully.…”

Section: Role Of Anticoagulation After Liver Transplantmentioning

confidence: 89%

Do Postliver Transplant Patients Need Thromboprophylactic Anticoagulation?

Mukerji

Karachristos

Maloo

et al. 2014

Clin Appl Thromb Hemost

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Postoperative thromboprophylactic anticoagulation against Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) is standard of care with current evidence-based guidelines. However, majority of liver transplant (LT) patients have thrombocytopenia and/or prolonged INR before surgery. Studies or guidelines regarding role of prophylactic anticoagulation after LT are lacking. There is a need to balance the risk of thrombosis with significant hemorrhage, implying those needing transfusion or return to OR due to bleeding. We conclude that after LT, anticoagulation is not required routinely for DVT/PE prophylaxis. Rather, it is indicated in specific circumstances, chiefly for prophylaxis of hepatic artery thrombosis or portal vein thrombosis in cases with use of grafts, pediatric cases, small size vessels, Budd Chiari syndrome, amongst others.

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“…No significant differences were evident in our study, however, when we focused on patients with a clinical decision–based ASA treatment period (n = 15) or on patients receiving no ASA (n = 4). One study found a lower incidence of late HAT in an ASA prophylaxis group versus patients who did not receive prophylaxis (0.4% versus 2.2%), and another study found similar frequencies of late HAT in patients using ASA and patients not using ASA (1.2% versus 1.0%). HAT studies of pediatric patients have found no significant differences in early HAT incidence between patients using ASA and patients not using ASA or in the frequency of ASA or alprostadil usage between patients with HAT and patients without HAT .…”

Section: Discussionmentioning

confidence: 99%

Late hepatic artery thrombosis after pediatric liver transplantation: A cross-sectional study of 34 patients

et al. 2014

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Hepatic artery thrombosis (HAT) after liver transplantation (LT) increases patient morbidity and mortality. Early HAT is considered to occur within the first month after LT, whereas late HAT occurs after the first month. Few studies have addressed late HAT after LT, especially in pediatric patients. Between 1987 and 2007, 99 patients (age < 18 years) underwent deceased donor LT. Thirty-four of 66 eligible patients (52%) underwent magnetic resonance imaging (MRI) according to protocol. On the basis of MRI findings, the patients were grouped as those who experienced late HAT and those who did not. Additionally, potential risk factors for late HAT were analyzed retrospectively. P values were adjusted for multiplicity. The median age at LT was 1.7 years [interquartile range (IQR) 5 1.0-9.6 years], and the median follow-up time at MRI was 9.5 years (IQR 5 4.0-16.4 years). Late HAT was diagnosed in 15 of the 34 patients [44%, 95% confidence interval (CI) 5 29%-61%] undergoing MRI and in 3 of these patients with angiography preceding MRI. Ultrasonography revealed late HAT in 6 of these 15 patients with a sensitivity of 40% (95% CI 5 20%-64%). The donor/recipient weight ratio remained significantly higher for the patients with late HAT versus the patients without late HAT after P values were adjusted (5.4 versus 1.9, P 5 0.03). No marked differences were observed in laboratory or liver histology parameters between the groups. In conclusion, late HAT is common after pediatric LT. The donor/recipient weight ratio was higher for patients with late HAT, and this was attributable to the lower weight of the recipients. No salient features of late HAT were observed with respect to laboratory or histological parameters, at least in terms of our study's cross-sectional period. Liver Transpl 20:591-600, 2014. V C 2014 AASLD.Received October 22, 2013; accepted January 30, 2014. See Editorial on Page 512Vascular complications after liver transplantation (LT) decrease both graft and patient survival.1 Hepatic artery thrombosis (HAT) is a major cause of retransplantation in the pediatric population.2 Early and late forms of HAT have been described, but the exact time interval for these 2 forms has not been established. However, most studies define early HAT as occurring within the first month after LT. 3The incidence of early HAT is higher in pediatric patients versus adult patients, and risk factors for early HAT have been proposed even in a contradictory manner.3 For example, in the setting of pediatric LT,

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Early Aspirin Therapy May Reduce Hepatic Artery Thrombosis in Liver Transplantation

Cited by 57 publications

References 12 publications

Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells

Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells

Do Postliver Transplant Patients Need Thromboprophylactic Anticoagulation?

Late hepatic artery thrombosis after pediatric liver transplantation: A cross-sectional study of 34 patients

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