Early behavioral effects of lead perinatal exposure in rat pups

Marco, Marion; Halpern, Ricardo; Barros, Helena Maria Tannhauser

doi:10.1016/j.tox.2005.02.007

Cited by 21 publications

(10 citation statements)

References 31 publications

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“…The finding that early environmental factors can influence calling behavior is in accordance with studies on the effects of prenatal malnutrition (Tonkiss et al 2003), prenatal stress (Morgan et al 1999;Williams et al 1998), perinatal asphyxia (Calmandrei et al 2004) or pre-and postnatal exposure of various substances, like alcohol (Barron and Gilbertson 2005;Marino et al 2002;Tatolli et al 2001), cocaine (Hahn et al 2000), lead (De Marco et al 2005), aluminum (Alleva et al 1998), or carbon monoxide (Di Giovanni et al 1993) on ultrasonic calling in infant rodents. However, in the natural context, variations in maternal care might be of major importance.…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andsupporting

confidence: 85%

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

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Infant rodents emit ultrasonic vocalizations when isolated from dam and littermates. Due to the context of their occurrence and the well described bidirectional modulation by substances known for their capability to influence emotionality, it was postulated that such calls reflect a negative affective state akin anxiety. Comparative studies observed pronounced differences in calling behavior between strains, which were paralleled by differences in maternal care. Therefore, it was recently hypothesized that early environmental factors may have strong impact on call production. Here, the relative contributions of genetic background, gender, and early environmental factors on calling behavior in C57BL/6JOlaHsd and C57BL/6NCrl were studied by using an embryo-transfer procedure. The results show that these sub-strains differ in the amount of calling and specific call features, like call frequency and amplitude. The embryo-transfer procedure indicated that the observed differences in the amount of ultrasonic calling are dependent on the dyadic interaction between mother and pup. Conversely, call features were primarily dependent on the genotype of the pup. Thus, call frequency and frequency modulation were solely dependent on the pup, i.e. its genotype and gender. However, there was one exception, namely call amplitude, which was solely dependent on the genotype of the mother, i.e. on early environmental factors. Furthermore, it was shown that particularly changes in call amplitude might be of high functional relevance, since a sub-strain dependent preference towards pups emitting calls with high amplitudes was observed. In total, it can be concluded that both genomic and nongenomic factors can tune calling behavior in mouse pups.

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Section: Within-strain Embryo-transfer: Comparison Between B6jola Andsupporting

confidence: 85%

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

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“…In addition early alterations can reverse due to compensation by behavioral or physiological means. Perinatal lead exposure causes a significant decrease in USVs in 7 day old rat pups but a significant increase later in 14 day old pups (DeMarco et al, 2005). This type of reversal can be related mainly to direct compensatory mechanisms or maturation of activational hormonal and neural systems during development.…”

Section: Animal Models Of Impaired Social Abilities and The Conditionmentioning

confidence: 99%

Rat pup social motivation: A critical component of early psychological development

Cromwell

2011

Neuroscience & Biobehavioral Reviews

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Examining the role of the offspring in early social dynamics is especially difficult. Human developmental psychology has found infant behavior to be a vital part of the early environmental setting. In the rodent model, the different ways that a rodent neonate or pup can influence social dynamics are not well known. Typically, litters of neonates or pups offer complex social interactions dominated by behavior seemingly initiated and maintained by the primary caregiver (e.g., the dam). Despite this strong role for the caregiver, the young most likely influence the litter dynamics in many powerful ways including communication signals, discrimination abilities and early approach behavior. Nelson and Panksepp (1996) developed a preference task to examine early rodent pup social motivation. We have used the same task to examine how variations in maternal care or different environmental perturbations could alter the rat pup preferences for social-related stimuli. Rat pups receiving low levels of maternal licking and grooming were impaired in maternal odor cue learning and emitted lower levels of 22 kHz ultrasounds compared to pups from the high licking and grooming cohort. Prenatal stress or early exposure to a toxicant (polychlorinated biphenyl) altered early social preferences in the rat pup in different ways indicating that diverse strategies are expressed and specific to the type of perturbation exposure. A greater focus on the offspring motivation following early 'stressors' will allow for more complete understanding of the dynamics in behavior during early social development. KeywordsAttachment emotion; epigenetics; stress; toxicology Early social development involves dynamic interactionsThe idea that there is a continuous interaction between individuals during early development is not new (Bishop and Merrill, 1951;Sander, 1962;Wolff, 1963). Bowlby emphasized this fact throughout his writings (1973 (1982) and a significant amount of child developmental work has focused on different aspects of this dynamic social environment (Courage and Howe, 2002;Pelaez et al., 2008;Repacholi, 2009). This has included work on joint attention (Grossberg and Vladusich, 2010), interactive speech and learning (Gogate et al., 2000) and the gradual development of theory of mind (Wellman and Brandone, 2009). These different Address Correspondence to: Howard Casey Cromwell, Department of Psychology, Psychology Building, Bowling Green State University, Bowling Green Ohio 43403, hcc@bgsu.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Bowlby's work originated out of studies on animal ...

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“…Various cellular proteins are altered upon challenge of lead induced oxidative stress and many undesired side effects of lead induced toxicity are known which include neurological [16], behavioural [17], immunological [18], renal [19], and hepatic [20] dysfunctions. We examined the expression of several proteins including HSP70, mortalin protein, immunoglobulin superfamily protein NCAM, and an intermediate filament protein GFAP to assess Ashwagandha mediated rejuvenating effects on characteristics like proliferation, adhesion, and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity

Kumar

Singh

Nazmi

et al. 2014

BioMed Research International

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Withania somnifera (Ashwagandha), also known as Indian Ginseng, is a well-known Indian medicinal plant due to its antioxidative, antistress, antigenotoxic, and immunomodulatory properties. The present study was designed to assess and establish the cytoprotective potential of Ashwagandha leaf aqueous extract against lead induced toxicity. Pretreatment of C6 cells with 0.1% Ashwagandha extract showed cytoprotection against 25 μM to 400 μM concentration of lead nitrate. Further pretreatment with Ashwagandha extract to lead nitrate exposed cells (200 μM) resulted in normalization of glial fibrillary acidic protein (GFAP) expression as well as heat shock protein (HSP70), mortalin, and neural cell adhesion molecule (NCAM) expression. Further, the cytoprotective efficacy of Ashwagandha extract was studied in vivo. Administration of Ashwagandha extract provided significant protection to lead induced altered antioxidant defense that may significantly compromise normal cellular function. Ashwagandha also provided a significant protection to lipid peroxidation (LPx) levels, catalase, and superoxide dismutase (SOD) but not reduced glutathione (GSH) contents in brain tissue as well as peripheral organs, liver and kidney, suggesting its ability to act as a free radical scavenger protecting cells against toxic insult. These results, thus, suggest that Ashwagandha water extract may have the potential therapeutic implication against lead poisoning.

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Early behavioral effects of lead perinatal exposure in rat pups

Cited by 21 publications

References 31 publications

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

Rat pup social motivation: A critical component of early psychological development

Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity

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