Early behavioral screening for antidepressants and anxiolytics

Castagné, Vincent; Porsolt, Roger D.; Moser, Paul

doi:10.1002/ddr.20145

Cited by 22 publications

(23 citation statements)

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“…In contrast, sedative effects are indicated by a decrease in exploration of both the open and closed arms. After acute administration, several monoamine reuptake inhibitors do not display anxiolytic activity in the elevated plus maze test (Castagné et al 2006). Nevertheless, activity of monoamine reuptake inhibitors can be revealed after chronic treatment (File et al 1999), consistent with their use as primary treatment in several anxiety disorders (Nutt 2005).…”

Section: Discussionmentioning

confidence: 78%

“…In addition to benzodiazepine-like anxiolytics, the Vogel test also detects the effects of substances acting on serotonergic uptake (Moser et al 1990;Dekeyne et al 2000;Chojnacka-Wojcik et al 2005) and several other pharmacological classes of substances with suspected clinical anxiolytic activity (Millan & Brocco 2003). Taken together, these data suggest that the Vogel test is useful for detecting a wide range of typical and atypical anxiolytics (Castagné et al 2006). In the present study, S100 antibodies increased punished drinking at 5 and 7 5 mL kg −1 , but not at 2.5 or 10 mL kg −1 .…”

Section: Discussionmentioning

confidence: 88%

“…The most often used parameters are the time spent in the open arms and the proportion of open arm entries (Moser 1989;Griebel et al 1997). Anxiolytics, and in particular benzodiazepines, increase the relative exploration of open arms (Graeff et al 1998;Castagné et al 2006). Excitatory effects may be associated with a non-specific increase in exploration of both the open and the closed arms.…”

Section: Discussionmentioning

confidence: 99%

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Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat

Castagné

Lemaire

Kheyfets³

et al. 2008

Journal of Pharmacy and Pharmacology

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S100 proteins are small calcium-binding proteins interacting with numerous intra- and extra cellular targets involved in diverse physiological functions. In particular, S100 proteins may be involved in the regulation of anxiety-related behaviour. In the present study, the effects of affinity-purified antibodies to S100 proteins administered orally at ultra-low doses were evaluated in pre-clinical tests for anxiolytic-like activity in the adult rat. In the Vogel conflict test in the rat, antibodies to S100 proteins increased punished drinking (anti-conflict effect) at 5 and 7.5 mL kg(-1), but not at 2.5 or 10 mL kg(-1). Antibodies to S100 proteins increased the percentage of entries into the open arms of an elevated plus-maze at 10 mL kg(-1), but not at lower doses. Taken together, these results indicate the presence of anxiolytic-like activity for antibodies to S100 proteins over the dose range 5-10 mL kg(-1) in the adult rat.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat

Castagné

Lemaire

Kheyfets³

et al. 2008

Journal of Pharmacy and Pharmacology

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“…Acute administration of the different drugs alone or combined did not produce any change compared with vehicle. In this regard, our data are in accordance with others' in which low doses of fluoxetine (8–20 mg·kg −1 ) (Castagné et al ., 2006; Ulak et al ., 2010), or the acute administration of ketanserin alone (Campos et al ., 2005) or in combination with some antidepressant drugs (Campos et al ., 2005) did not produce any significant change in immobility time in the FST.…”

Section: Discussionmentioning

confidence: 99%

Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain‐derived neurotrophic factor, β‐catenin and antidepressant‐like effects

Pilar-Cuéllar

Vidal

Pazos

2012

British J Pharmacology

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BACKGROUND AND PURPOSE5-HT2A receptor antagonists improve antidepressant responses when added to 5-HT-selective reuptake inhibitors (SSRIs) or tricyclic antidepressants. Here, we have studied the involvement of neuroplasticity pathways and/or the 5-hydroxytryptaminergic system in the antidepressant-like effect of this combined treatment, given subchronically. EXPERIMENTAL APPROACHExpression of brain-derived neurotrophic factor (BDNF) and its receptor (TrkB), 5-bromo-2′-deoxyuridine (BrdU) incorporation, and b-catenin protein expression in different cellular fractions, as well as 5-HT1A receptor function were measured in the hippocampus of rats treated with fluoxetine, ketanserin and fluoxetine + ketanserin for 7 days, followed by a forced swimming test (FST) to analyse antidepressant efficacy. KEY RESULTSmRNA for BDNF was increased in the CA3 field and dentate gyrus of the hippocampus by combined treatment with fluoxetine + ketanserin. Expression of b-catenin was increased in total hippocampal homogenate and in the membrane fraction, but unchanged in the nuclear fraction after combined treatment with fluoxetine + ketanserin. These effects were paralleled by a decreased immobility time in the FST. There were no changes in BrdU incorporation, TrkB expression and 5-HT1A receptor function in any of the groups studied. CONCLUSIONS AND IMPLICATIONSThe antidepressant-like effect induced by subchronic co-treatment with a SSRI and a 5-HT2A receptor antagonist may mainly be because of modifications in hippocampal neuroplasticity (BDNF and membrane-associated b-catenin), without a significant role for other mechanisms involved in chronic antidepressant response, such as hippocampal neuroproliferation or 5-HT1A receptor desensitization in the dorsal raphe nucleus.

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“…In pre-clinical research, antidepressant treatment is often delivered intraperitoneally [27][28][29][30][31][32] or subcutaneously [33] , while other approaches are applied less frequently [34][35][36] . However, the oral administration of antidepressant-like treatment and other pharmacological drug candidates is also effective for small rodents [7] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Voluntary Imipramine Intake via Food and Water in Paradigms of Anxiety and Depression in naïve Mice

Costa-Nunes

Bakhmet

Araújo-Correia

et al. 2016

Translational Neuroscience and Clinics

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Objective:We sought to investigate the efficacy of oral dosing in mice with imipramine (7mg/kg/day) via water or in food pellets, and to compare its effects in the paradigms of learned helplessness, locomotion, hedonic state, and anxiety. Methods: Water and food consumption were measured to determine daily imipramine dosage in C57BL/6N mice. Next, baseline scores for O-maze, dark/light box, and sucrose tests were measured. Mice were then subjected to a 4-week treatment of voluntary ingestion of drinking water or food pellets containing imipramine. Lastly, all groups were subjected to novel cage, open field, O-maze, dark/light box, sucrose test, and forced swim test to assess the effects of the treatment. Results: In naïve mice, imipramine delivered via food, induced a reduction of total floating and increased latency in the forced swim test, i.e., antidepressant-like effects. No other significant effects were found. Dosing with water did not change behavior in the forced swim, sucrose preference test, anxiety, or locomotor paradigms, but increased exploration in the novel cage. Conclusions: Voluntary ingestion is an effective method of chronic dosing with imipramine in naïve mice. Delivery of imipramine with food pellets elicits antidepressant-like effects in the forced swim test, with no effects on anxiety, locomotion, or preference behaviors. In contrast, no such effects were observed with treatment via drinking water, suggesting that a higher dose may be required. Our work argues for a broader use of oral delivery using food-treated pellets, in small rodent models of pre-clinical depression. It may substantially improve animal welfare and overcome potential confounds in translational research, which are frequently associated with adverse chronic invasive pharmacotherapies. Citation Costa-Nunes JP, Bakhmet A, Araújo-Correia M, Valença AB, Strekalova T, Steinbusch HWM. Effects of voluntary imipramine intake via food and water in paradigms of anxiety and depression in naïve mice. Transl. Neurosci. Clin. 2016, 2(3): 172-182.

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Early behavioral screening for antidepressants and anxiolytics

Cited by 22 publications

References 79 publications

Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat

Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat

Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain‐derived neurotrophic factor, β‐catenin and antidepressant‐like effects

Effects of Voluntary Imipramine Intake via Food and Water in Paradigms of Anxiety and Depression in naïve Mice

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