Early bile duct cancer

Myung, Jae Kyung; Kim, Myung–Hwan; Jang, Se Jin

doi:10.3748/wjg.v13.i25.3409

Cited by 18 publications

(16 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although patients with EHC generally have an unfavorable prognosis after resection, [1][2][3][4][5] it has been reported that resection provides favorable long-term outcomes for patients with pT1 tumors. [8][9][10][11][12][13] The Japanese Society of Biliary Surgery has defined ''early'' cholangiocarcinoma as a pT1 (or pTis) tumor based on favorable postresectional survival.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Despite the overall unfavorable outcome associated with resection for EHC, [1][2][3][4][5] pathologic T1 (pT1) tumors, as defined by the American Joint Committee on Cancer (AJCC) staging system, 6 generally show favorable outcomes after resection. [7][8][9][10][11][12][13] pT1 EHC includes tumors that are limited to the mucosa and tumors that have invaded (but not penetrated) the fibromuscular layer.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma

Nagahashi

Shirai

Wakai

et al. 2009

Cancer

View full text Add to dashboard Cite

BACKGROUND:We tested the hypothesis that in patients with T1 extrahepatic cholangiocarcinoma (EHC), prognosis postresection is significantly different for those with tumors that are limited to the mucosa than for those with tumors that have invaded (but not penetrated) the fibromuscular layer. METHODS: A retrospective analysis was conducted of 33 consecutive patients with pathologic T1 (pT1) EHC tumors. According to the depth of invasion, the pT1 tumors were divided into 2 groups: Group 1, tumors that were limited to the mucosa (mucosal tumors); and Group 2, tumors that had invaded (but not penetrated) the fibromuscular layer (fibromuscular layer-invasive tumors). Longterm outcomes after resection were compared between the 2 groups for a median follow-up time of 175 months. RESULTS: Eighteen patients had mucosal tumors and 15 patients had tumors that had invaded the fibromuscular layer. None of the patients with mucosal tumors had lymphovascular invasion, whereas 3 of the patients with fibromuscular layer-invasive tumors had lymphovascular invasion (P ¼.083). Overall survival after resection was better in Group 1 than in Group 2 (cumulative 10-year survival rate, 100% vs 52%; P ¼.024). The rate of disease-free survival after resection was higher in Group 1 than in Group 2 (cumulative disease-free 10-year survival rate, 100% vs 56%; P ¼.022). CONCLUSIONS: The long-term outcome after resection for EHC is significantly better for patients with mucosal tumors than for patients with fibromuscular layer-invasive tumors. This suggests that the depth of tumor invasion affects the postresection prognosis for patients with pT1 EHC. Cancer 2010;116:400-5.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma

Nagahashi

Shirai

Wakai

et al. 2009

Cancer

View full text Add to dashboard Cite

show abstract

“…Indeed, the preoperative radiologic diagnosis of early bile duct cancer is important for improving the patient prognosis as in many instances a better outcome can be obtained when tumor resection is performed (6,8,9). To the contrary, for patients with carcinoma infiltrating beyond the bile duct, the prognosis is poor even after extensive radical surgery (3)(4)(5)(6)(7)(8)23).…”

Section: Discussionmentioning

confidence: 99%

“…Although there have been no worldwide accepted criteria for early bile duct cancer, it is defined as a carcinoma whose invasion is confined within the fibromuscular layer of the bile duct and without distant metastasis irrespective of possible lymph node involvement (5,9). Considering that the prognosis of bile duct cancer is generally poor, early detection using noninvasive cross-sectional imaging is very important in improving the prognosis.…”

mentioning

confidence: 99%

“…Currently, various invasive and noninvasive imaging modalities, such as ultrasound, CT, MR imaging with/ without MR cholangiopancreatography (MRCP), endoscopic retrograde cholangiography, and endoscopic ultrasound, can be used to diagnose bile duct cancer (2,12). Among these modalities, contrast-en-hanced MR imaging combined with MRCP using stateof-the-art MR scanners, can facilitate viewing longitudinal cancer spread by simultaneously assessing bile ducts upstream and downstream and can permit assessment of the vessels and the depth of invasion (9,(13)(14)(15)(16)(17). Therefore, the purposes of this study are to retrospectively evaluate the imaging features of early bile duct carcinoma on unenhanced and contrast-enhanced MR images as well as on MR cholangiography , and to correlate them with the clinicopathologic findings.…”

mentioning

confidence: 99%

See 1 more Smart Citation

MR imaging findings of early bile duct cancer

Lee

Kim

et al. 2008

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To retrospectively evaluate the MR imaging features of early bile duct cancer and to correlate them with the clinicopathologic findings. Materials and Methods:This retrospective study was approved by our institutional review board, and informed consent was waived. Seventeen patients with surgically proven early bile duct cancer who had undergone preoperative MR cholangiopancreatography with gadolinium-enhanced MR imaging, were included in this study. Two, experienced radiologists evaluated the MR images in consensus regarding the following findings: tumor number and morphology; signal intensity of the tumor; sharpness of the outer border of the bile duct wall; enhancement pattern of the tumor; and the presence of enlarged peribiliary lymph nodes. Another radiologist measured the SNR of the tumor and bile duct wall on gadolinium-enhanced MRI during the dynamic phases to evaluate the tumor enhancement degree. Results:In all patients, MR imaging demonstrated single or multiple intraluminal bile duct masses showing a sharply defined outer margin. The most common enhancement pattern of the biliary lesions showed heterogeneous amorphous enhancement or heterogeneous enhancement with central, dot-like structures or vascular structures (76.5%, 13/17 patients). The difference of SNR between bile duct and tumor was greatest in the equilibrium phase (P Ͻ 0.05). Conclusion:MRCP combined with dynamic contrast-enhanced MRI can be useful for detecting early bile duct cancers. Common MR findings of early bile duct cancer include one or more inhomogeneously enhancing intraductal masses with clear outer margins and preservation of the bile duct wall.

show abstract

UV‐curable methacrylic epoxy dispersions for cationic electrodeposition coating

Kim

Hong

2006

J of Applied Polymer Sci

View full text Add to dashboard Cite

UV-curable epoxy dispersions were prepared for cationic electrodeposition coating. Sequential reactions were used to introduce methacrylate groups to the epoxyamine polymer as coupling agents to the multifunctional acrylates. The molecular weight values of the prepared epoxy-amine polymer were M n ¼ 2800 and M w ¼ 4300. The neutralized epoxy-amine polymer containing photoinitiator with or without multifunctional acrylate (pentaerythritol triacrylate, PETA) could be dispersed into a stable dispersion without any phase separation. The size of the particles in these epoxy dispersions was approximately 77.7 nm, and increased with the incorporation of PETA. The electrodeposition process was introduced to the prepared epoxy dispersions, and the electrodeposited films were cured by UV irradiation after a 10-min flash off at 808C. Studies of the kinetics using photo-DSC revealed that the crosslinked films containing PETA gave a higher conversion rate than those without PETA, resulting in better resistance to methyl ethyl ketone.

show abstract

Early bile duct cancer

Cited by 18 publications

References 47 publications

Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma

Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma

MR imaging findings of early bile duct cancer

UV‐curable methacrylic epoxy dispersions for cationic electrodeposition coating

Contact Info

Product

Resources

About