Early blastomere multinucleation evaluated in 2-cells embryos by time-lapse system is not affecting implantation rate

Utilization and Outcome of Abnormal 2PN Human Embryos

“…According to the data of this study, the transfer of these embryos after blastocyst formation was acceptable from the clinical pregnancy rate to the live birth rate. Many of these embryos are selfcorrecting during development [21,23] and abandoning them is unscienti c, wasteful, and not a good choice for the patient. Due to the limited space, this article does not expand on the genetic aspects, but the good ending is not all but what we are looking for.…”

“…Embryos that blastomere containing more than one single interphase nucleus on Day-2 or Day-3 are known as MNB [5] .The causative factors may be response to ovarian stimulation and intrafollicular hypoxia disturbing oocyte spindle organization during the oocyte retrieval process [8,9] .MNB may result from insu cient culture medium or from cooling of the oocyte during manipulation leading to alterations of the cytoskeleton [10,11] .Previous studies demonstrated that embryos with MNB had a decreased implantation potential, an increased level of chromosome abnormality [12,13,14,15] and an increased risk of spontaneous abortion [5,8,16,17,12,14,15] .Moreover, multinucleated embryos development slower than non-multinucleated embryos [18] .Nevertheless, still had some MNB embryos were able to achieve pregnancies [19,20] and early multinucleation was not directly related to a lower implantation rate [18,21,22] .…”