Early bone apposition to hydrophilic and hydrophobic titanium implant surfaces: a histologic and histomorphometric study in minipigs

Abstract

Substantial bone apposition occurs between day 5 and day 10. The data suggest that the hydrophilic surface can provoke a slight tendency toward increased bone apposition in minipigs after 15 days. A direct comparison of two hydrophilic surfaces with varying geometries is of limited relevance.

Accelerated Healing Period with Hydrophilic Implant Placed in Sheep Tibia

“…This finding is similar to that of a previous clinical trial that investigated the early steps of healing in the presence of hydrophilic surfaces and found a superior degree of osseointegration after 14 days of implantation (14). Moreover, a study using mini-pig model found great bone apposition on hydrophilic surfaces 10 and 15 days post-implant placement (6). This finding corresponds very well with the same parameters assessed in dog mandibles, which showed enhanced bone formation surrounding the hydrophilic surface of implants after 14 days of healing (3).…”

“…Hydrophilic implant surfaces account for faster wettability, favoring cell-implant contact, the initial phases of wound healing and a cascade of events leading to the osteogenesis (3). At the end, bone apposition increase bone-implant contact (BIC) (4) and improve bonding strength during the early stages of bone repair (5,6).…”

“…In vivo evaluation have presented increase of bone-to-implant contact (BIC) in studies using mini-pigs model (6), dogs (11) and rats (12).…”

“…In this analysis, both implants tested are commercially available; however, regulators and professionals must have evidence that demonstrate the safety and efficacy of these products based on standardized protocols in order to reduce the use of inefficient products (6,14).…”

In vitro evaluation of the biological compatibility and antibacterial activity of a bone substitute material consisting of silver‐doped hydroxyapatite and Bio‐Oss®

“…Vasak C found that substantial bone apposition occurred between day 5 and 10 after submerged healing of implants. 26 Kohal RJ confirmed retarded cell proliferation on the TiUnite V R surface during the first 7 days. 27 Therefore, the initial 7 days were important for osseointegration.…”