Early brain metastases in endometrial carcinoma

Successful treatment with stereotactic radiosurgery for brain metastases of endometrial carcinoma: A case report and review of the literature

“…Brain metastases are usually considered to be a late event in the course of disease, and the previously reported patients developed brain metastases on average 27 months after hysterectomy (3)(4)(5)26) . However, poorly differentiated endometrial neoplasms with vessel permeation and deep myometrial invasion can metastasize to the brain early in the course of disease, even before clinical symptoms of the primary tumor become apparent (28) . When blood vessel invasion was present, the median time interval between primary treatment and distant metastasis was significantly shorter than without blood vessel invasion.…”

Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review

“…A clinical judgment should be individualized, bearing in mind the potential for long-term survival, an awareness of the advance in a variety of therapy in treating metastatic cancer, and the probability of changing patterns of relapse with the improvement of systemic therapy. (109) Patients c and d; deep myometrial invasion (109,115) Patient e; grade 3 tumor, deep myometrial invasion, prior lung metastasis (116) II 2 Patient a; cervical involvement (112) Patient b; grade 3 tumor, deep myometrial invasion, cervical involvement, lymphovascular space invasion (113) III 2 Patient a; uncontrolled primary disease, lung metastases (114) Patient b; adenosquamous histology, uncontrolled primary disease, lymph node involvement (114) IV 7 Patient a; grade 3 tumor (110) Patient b; bone metastases (114) Patients c-g; grade 3 tumor, deep myometrial invasion, metastatic disease at other sites, lymph node involvement (107,108) …”

“…Factors examined for their possible association with CNS metastasis from endometrial cancer have included unfavorable clinical disease stage or high-grade tumor (109,110) , lymph node involvement (111) , deep myometrial invasion (108) , cervical involvement (108,110) , and lymphovascular space invasion (109,110) . Cases in which the tumor is high grade and lymphovascular space invasion and deep myometrial invasion are present may be more prone to metastasize earlier in the course of the disease (108) .…”

“…This review revealed 16 patients from nine published studies who underwent surgery for brain metastases from endometrial cancer (107)(108)(109)(110)(112)(113)(114)(115)(116) (Table 7). Six of seven patients with stage IV disease had brain metastasis at diagnosis, and the seventh developed brain metastasis 3 months after bone metastasis at primary diagnosis.…”

“…Six of seven patients with stage IV disease had brain metastasis at diagnosis, and the seventh developed brain metastasis 3 months after bone metastasis at primary diagnosis. Five patients presented with neurologic manifestations that resulted in diagnosis of primary tumor upon further investigations (107,108,110) . The characteristic features of the diseases or risk factors in these patients are summarized in Table 8.…”