Early cases of acute infectious respiratory syndrome treated with photobiomodulation, diagnosis and intervention: Two case reports

Pelletier-Aouizerate, Michèle; Zivic, Yvona

doi:10.1002/ccr3.4058

Cited by 9 publications

(8 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PBM can be used adjunctively with other remedies, as a primary therapeutic modality, in palliative care[ 24 ], [ 25 ] and for prophylaxis[ 26 ], [ 27 ]. In the treatment of COVID‐19, the primary goal of PBM is symptomatic relief—to restore breathing; reduce (or break) fever; ameliorate coughing; mitigate aches and pains; shorten the duration of the viral infection; combat pneumonia or other secondary infections; reduce mucus, edema and congestion in the bronchia, alveoli and sinuses; and circumvent the need for ventilation.…”

Section: Introductionmentioning

confidence: 99%

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

Williams

Raimondo²,

Cahn

et al. 2021

Journal of Biophotonics

View full text Add to dashboard Cite

A nonrandomized 50‐person case study of COVID‐19‐positive patients was conducted employing (for the first time) a regimen of whole‐organ deep‐tissue transdermal dynamic photobiomodulation (PBM) as a primary (or exclusive) therapeutic modality in the treatment of coronavirus. Therapy sessions comprised algorithmically alternating red (650 nm) and near‐infrared (NIR; 850 nm) LEDs with an average irradiance of 11 mW/cm 2 dynamically sequenced at multiple pulse frequencies. Delivered via 3D bendable polymeric pads maintaining orthogonal optical incidence to body contours over 1,000 cm 2 , a single 84‐minute session concurrently delivered 20 kJ to the sinuses and 15 kJ to each lung at skin temperatures below 42°C. Therapeutic outcomes observed include significant reductions in the duration and severity of disease symptoms. Acute conditions including fever, body aches (BA) and respiratory distress comprising paroxysmal coughing; lung congestion, dyspnea and hypoxia; sinus congestion; acute eye inflammation; and extreme malaise were eliminated in 41/50 patients within 4 days of commencing PBM treatments with 50/50 patients fully recovering within 3 weeks with no supplemental oxygen requirements. SpO 2 concentrations improved as much as 9 points (average 2.5 points) across the entire study population. The PBM sessions required to completely resolve COVID‐19 conditions appears monotonically correlated to the time‐to‐treatment (TTTx)—the delay between the onset of a patient's symptoms and commencing PBM therapy. In contrast, acute inflammatory symptoms were resolved within 4 days irrespective of TTTx.

show abstract

Section: Introductionmentioning

confidence: 99%

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

Williams

Raimondo²,

Cahn

et al. 2021

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…Recently, the impact of blue light (450, 454, and 470 nm) on SARS-CoV-2 inactivation was reported [102]. Furthermore, a recent case report suggested the therapeutic potential of phototherapy with a red light (630 + 660 nm) for the alleviation of respiratory symptoms, pulmonary inflammation, and hypoxia [103]. The beneficial effect of red light (660 nm) was also confirmed in an experimental model of sepsis-associated ALI [104].…”

Section: Discussionmentioning

confidence: 92%

Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19

Nakano

Chiang

Chen

et al. 2021

IJERPH

View full text Add to dashboard Cite

Most humans depend on sunlight exposure to satisfy their requirements for vitamin D3. However, the destruction of the ozone layer in the past few decades has increased the risk of skin aging and wrinkling caused by excessive exposure to ultraviolet (UV) radiation, which may also promote the risk of skin cancer development. The promotion of public health recommendations to avoid sunlight exposure would reduce the risk of skin cancer, but it would also enhance the risk of vitamin D3 insufficiency/deficiency, which may cause disease development and progression. In addition, the ongoing global COVID-19 pandemic may further reduce sunlight exposure due to stay-at-home policies, resulting in difficulty in active and healthy aging. In this review article, we performed a literature search in PubMed and provided an overview of basic and clinical data regarding the impact of sunlight exposure and vitamin D3 on public health. We also discuss the potential mechanisms and clinical value of phototherapy with a full-spectrum light (notably blue, red, and near-infrared light) as an alternative to sunlight exposure, which may contribute to combating COVID-19 and promoting active and healthy aging in current aged/superaged societies.

show abstract

“…Of 5 studies, only 1 clinical trial included PBMT to treat COVID-19, and the rest 4 were either case reports or case series. 8,[53][54][55][56] PBMT with stimulating immune response locally and systemically, increasing local circulation, promoting homeostasis, and relieving inflammation in treated organs and tissue accelerate the improvement of COVID-19. 57 Additional to the influencing immune system, PBMT has directly contribute in pathogen clearance.…”

Section: Clinical Implications: Potential Treatment For Covid-19mentioning

confidence: 99%

“…Of 5 studies, only 1 clinical trial included PBMT to treat COVID-19, and the rest 4 were either case reports or case series. 8,53 -56…”

Section: Clinical Implications: Potential Treatment For Covid-19mentioning

confidence: 99%

The Probable Protective Effect of Photobiomodulation on the Immunologic Factor’s mRNA Expression Level in the Lung: An Extended COVID-19 Preclinical and Clinical Meta-analysis

Arjmand

Rahim

2023

Clin Med�Insights�Pathol

View full text Add to dashboard Cite

Background: Different expression of cytokine genes in the body determines the type of immune response (Th1 or Th2), which can play an important role in the pathogenesis of the COVID-19 disease. Aims: This meta-analysis was conducted to evaluate the probable effect of photobiomodulation (PBMT) therapy on the cytokine’s mRNA expression in the lung. Methods: We systematically searched indexing databases, including PubMed/Medline, ISI web of science, Scopus, EMBASE, and Cochrane central, using standard terms without language, study region or type restrictions. Studies on using PBM in lung injury modeling with samples collected from lung tissue to observe IL-1β, TNF-α, IL-10, and IL-6 mRNA expression were included. RevMan 5.3 software was used for data analysis and standardized mean difference as effect size. Results: Of the 438 studies found through initial searches, 17 met the inclusion criteria. The main properties of 13 articles on 384 animals included in this meta-analysis with a wide range of species include rats (n = 10) and rabbits (n = 3). The analysis revealed that PBMT reduced the mRNA expression of TNFα (SMD: −3.70, 95% CI: −6.29, −1.11, P = .005, I2 = 71%) and IL-1β (SMD: −5.85, 95% CI: −8.01, −3.69, P < .00001, I2 = 37%) significantly, but no statistically significant reduction in IL-6 (SMD: −2.89, 95% CI: −5.79, 0.01, P = .05, I2 = 88%) was observed compared with the model controls. Also, PBMT increased IL-10 mRNA expression significantly compared with the model controls (SMD: 1.04, 95% CI: 0.43, 1.64, P = .0008, I2 = 17%). Conclusion: This meta-analysis revealed that the PBMT utilizes beneficial anti-inflammatory effects and modulation of the immune system on lung damage in animal models and clinical studies. However, animal models and clinical studies appear limited considering the evidence’s quality; therefore, large clinical trials are still required.

show abstract

Early cases of acute infectious respiratory syndrome treated with photobiomodulation, diagnosis and intervention: Two case reports

Cited by 9 publications

References 49 publications

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

Sunlight Exposure and Phototherapy: Perspectives for Healthy Aging in an Era of COVID-19

The Probable Protective Effect of Photobiomodulation on the Immunologic Factor’s mRNA Expression Level in the Lung: An Extended COVID-19 Preclinical and Clinical Meta-analysis

Contact Info

Product

Resources

About