Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study

Dang, Yuxue; Shi, Kun; Wang, Xiaoming

doi:10.3389/fphys.2017.00237

Cited by 12 publications

(9 citation statements)

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“…FETAL CENTRAL NERVOUS SYSTEM (CNS) injury is the important reason for perinatal death and disability . For example, basal ganglia region (BGR) injury is the main cause of permanent dysneuria and cerebral palsy in the perinatal period . Early detection and quantitative assessment of fetal CNS injury is the key for clinicians to make effective interventions.…”

mentioning

confidence: 99%

Fetal brain development at 25–39 weeks gestational age: A preliminary study using intravoxel incoherent motion diffusion‐weighted imaging

Yuan

Cui

et al. 2019

Magnetic Resonance Imaging

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Background The fetal brain developmental changes of water diffusivity and perfusion has not been extensively explored. Purpose/Hypothesis To evaluate the fetal brain developmental changes of water diffusivity and perfusion using intravoxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI). Study Type Prospective. Population Seventy‐nine normal singleton fetuses were scanned without sedation of healthy pregnant women. Field Strength/Sequence 5 T MRI/T1/2‐weighted image and IVIM‐DWI. Assessment Pure diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) values were calculated in the frontal (FWM), temporal (TWM), parietal (PWM), and occipital white matter (OWM) as well as cerebellar hemisphere (CH), basal ganglia region (BGR), thalamus (TH), and pons using an IVIM model. Statistical Tests One‐way analysis of variable (ANOVA) followed by Bonferroni post‐hoc multiple comparison was employed to reveal the difference of IVIM parameters among the investigated brain regions. The linear and the nonlinear polynomial regression analyses were utilized to reveal the correlation between gestational age (GA) and IVIM parameters. Results There were significant differences in both D (F(7,623) = 96.64, P = 0.000) and f values (F(7,623) = 2.361, P = 0.0219), but not D* values among the varied brain regions. D values from TWM (r2 = 0.1402, P = 0.0002), PWM (r2 = 0.2245, P = 0.0002), OWM (r2 = 0.2519, P = 0.0002), CH (r2 = 0.2245, P = 0.0002), BGR (r2 = 0.3393, P = 0.0001), TH (r2 = 0.1259, P = 0.0001), and D* value from pons (r2 = 0.2206, P = 0.0002) were significantly correlated with GA using linear regression analysis. Quadratic regression analysis led to results similar to those using the linear regression model. Data Conclusion IVIM‐DWI parameters may indicate fetal brain developmental alterations but the conclusion is far from reached due to the not as high‐powered correlation between IVIM parameters and GA. Level of Evidence: 2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:899–909.

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confidence: 99%

Fetal brain development at 25–39 weeks gestational age: A preliminary study using intravoxel incoherent motion diffusion‐weighted imaging

Yuan

Cui

et al. 2019

Magnetic Resonance Imaging

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“…Similar results were observed in the cerebrospinal fluid (CSF) or cerebral areas of patients after a traumatic brain injury [53,54]. Higher levels of glutamate have also been described in the CSF of infants correlating with the severity of hypoxic-ischemic (H-I) encephalopathy [55], and indeed levels of glutamate remain elevated for days in animal models of pre-term H-I injury [56,57,58]. Glutamate excitotoxicity is also an important event in chronic neurodegenerative diseases [49].…”

Section: Introductionmentioning

confidence: 60%

Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease

Ceprián

Fulton

2019

IJMS

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Glia form a central component of the nervous system whose varied activities sustain an environment that is optimised for healthy development and neuronal function. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA)-type glutamate receptors (AMPAR) are a central mediator of glutamatergic excitatory synaptic transmission, yet they are also expressed in a wide range of glial cells where they influence a variety of important cellular functions. AMPAR enable glial cells to sense the activity of neighbouring axons and synapses, and as such many aspects of glial cell development and function are influenced by the activity of neural circuits. However, these AMPAR also render glia sensitive to elevations of the extracellular concentration of glutamate, which are associated with a broad range of pathological conditions. Excessive activation of AMPAR under these conditions may induce excitotoxic injury in glial cells, and trigger pathophysiological responses threatening other neural cells and amplifying ongoing disease processes. The aim of this review is to gather information on AMPAR function from across the broad diversity of glial cells, identify their contribution to pathophysiological processes, and highlight new areas of research whose progress may increase our understanding of nervous system dysfunction and disease.

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“…The study of Perciaccante et al ( 38 ), a study in which the population underwent intravital microscopy, suggests that hypothermia does not affect cerebral arteriolar dilatation to NMDA during and following ischemia, indicating that the cerebroprotective effects of hypothermia therapy are not mediated by NMDA. The study of Dang et al ( 31 ), using proton magnetic resonance spectroscopy ( 1 H-MRS) and diffusion-weighted imaging (DWI), showed that the glutamate level in the basal ganglia underwent a “two-phase” change after HI: first a rise in glutamate after 0–6 h and secondly a rise in glutamate after 24–30 h, due to reperfusion injury.…”

Section: Resultsmentioning

confidence: 99%

Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy: A Systematic Review for Future Research

et al. 2021

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Worldwide neonatal hypoxic-ischemic encephalopathy (HIE) is a common cause of mortality and neurologic disability, despite the implementation of therapeutic hypothermia treatment. Advances toward new neuroprotective interventions have been limited by incomplete knowledge about secondary injurious processes such as cerebral hyperperfusion commonly observed during the first 1–5 days after asphyxia. Cerebral hyperperfusion is correlated with adverse neurodevelopmental outcome and it is a process that remains poorly understood. In order to provide an overview of the existing knowledge on the pathophysiology and highlight the gaps in current understanding of cerebral hyperperfusion in term animals and neonates with HIE, we performed a systematic research. We included papers scoping for study design, population, number of participants, study technique and relevant findings. Methodological quality was assessed using the checklist for cohort studies from The Joanna Briggs Institute. Out of 2,690 results, 34 studies were included in the final review—all prospective cohort studies. There were 14 studies of high, 17 moderate and 3 of low methodological quality. Data from the literature were analyzed in two main subjects: (1) Hemodynamic Changes subdivided into macro- and microscopic hemodynamic changes, and (2) Endogenous Pathways which was subdivided into N-methyl-D-aspartate/Mitogen activated protein kinase (NDMA/MAPK), Nitric Oxide (NO), prostanoids and other endogenous studies. Cerebral hyperperfusion in term neonates with HIE was found to be present 10–30 min after the hypoxic-ischemic event and was still present around day 10 and up to 1 month after birth. Cerebral hyperperfusion was also characterized by angiogenesis and cerebral vasodilation. Additionally, cerebral vasodilation was mediated by endogenous pathways such as MAPK through urokinase Plasminogen Activator (uPA), by neuronal NO synthase following NMDA and by prostanoid synthesis. Future research should elucidate the precise role of NMDA, MAPK and prostanoids in cerebral hyperperfusion. Moreover, research should focus on possible interventions and the effect of hypothermia on hyperperfusion. These findings should be taken into account simultaneously with brain imagining techniques, becoming a valuable asset in assessing the impact in neurodevelopmental outcome.

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Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study

Cited by 12 publications

References 61 publications

Fetal brain development at 25–39 weeks gestational age: A preliminary study using intravoxel incoherent motion diffusion‐weighted imaging

Fetal brain development at 25–39 weeks gestational age: A preliminary study using intravoxel incoherent motion diffusion‐weighted imaging

Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease

Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy: A Systematic Review for Future Research

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