“…One-way or two-way repeated measures (pretest vs. posttest) MANOVA were used to assess the main effects of intervention and conditions, and the interaction effects of conditions and time (West, Sanders, Cleghorn, & Davies, 2010). In addition, linear (simple or multiple) and logistic regression have been applied to model the changing patterns of outcomes over time (Brotman et al, 2012;Plachta-Danielzik, Landsberg, Lange, Seiberl, & Muller, 2011). Blackwell and colleagues (2006) suggested that mixed-effects regression models provide a more flexible and accurate framework for managing repeated measures data compared to conventional statistical techniques, such as, t-test, ANOVA, repeated measures ANOVA/MANOVA, and linear regression et al For many longitudinal studies, data collected for each subject is correlated over time.…”