Early childhood respiratory symptoms and the subsequent diagnosis of asthma

Dodge, Russell; Martínez, Fernando D.; Cline, Martha G.; Lebowitz, Michael D.; Burrows, Benjamin

doi:10.1016/s0091-6749(96)70225-7

Cited by 79 publications

(64 citation statements)

References 18 publications

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“…Follow-up at 8 and 13 years have found that, although mild bronchiolitis is a powerful predictor of wheezing at age of 8 years, it is only a weak and non-statistically significant predictor of wheezing at age 13 years [49]. Similar conclusions have also been drawn from the Tucson whole population birth cohort, in that RSV bronchiolitis before 3 years was associated with a significant increase in the risk of subsequent wheezing during the first 10 years of life, but decreased with age and was no longer significant by age 13 years [23,24].…”

Section: Respiratory Infectionssupporting

confidence: 68%

“…The prevalence of asthma was significantly higher in males than in females at all ages up to 11 years of age, but not at 13 years [6,[21][22][23]. In the Melbourne followup studies, a history of wheeze in the past 12 months was more common in 7-year-old males than females, a sex difference that became less obvious at 12 years and that had disappeared by 15 years.…”

Section: Sex Differencesmentioning

confidence: 89%

“…The Tucson Children's Respiratory Study (AZ, USA) found that children who had wheezed before 3 years of age but not at 6 years (transient wheezers), who had diminished airway function in the 1st year of life and at 6 years of age, were more likely to have mothers who smoked, negative skin-prick tests to common inhaled allergens and normal serum immunoglobulin (Ig)E than those with persistent symptoms [6,[21][22][23][24][25].…”

Section: Natural Historymentioning

confidence: 99%

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Prognosis of wheezing and asthma presenting in early childhood

Helms

Amin

2004

Breathe

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Key pointsChildhood asthma and wheezing illness encompass a wide clinical spectrum.Most children with asthma first present before the age of 3 years.Coexistent atopy and initial disease severity carry a poor long-term prognosis.A switch from male to female predominance occurs at puberty.Good prognostic factors include presentation before 2 years of age and exclusively virally induced episodes.CME article: educational aimsTo identify the different types of wheezing illness in asthma that present in childhood.To aid healthcare professionals in the discussion of medium- to long-term prognosis with parents of children presenting with wheezing illness.To place prophylactic therapy in the context of the natural history of the disease.SummaryChildhood asthma covers a wide spectrum, ranging from mild-intermittent to severe-persistent disease, with different natural histories. Female sex, age at presentation, atopic constitution, parental atopy, and severity and frequency of attacks can all be identified as risk factors for persistence into adult life, while others, including maternal smoking, prematurity and bronchiolitis of infancy, do not appear to be associated to such an extent. The use of prognostic features alongside assessment of disease severity should inform long-term clinical management and be useful in counselling the child and her/his family.

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Section: Respiratory Infectionssupporting

confidence: 68%

Section: Sex Differencesmentioning

confidence: 89%

Section: Natural Historymentioning

confidence: 99%

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Prognosis of wheezing and asthma presenting in early childhood

Helms

Amin

2004

Breathe

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“…We found that high-acetate levels in pregnant individuals correlated with reduced GP visits for cough and wheeze per year and wheeze in the first 12 months for their offspring. These features are some of the most significant predictors for the subsequent development of asthma in later life 47,48 . Future analysis, when the children are older, will determine whether these children do indeed go on to develop asthma.…”

Section: Discussionmentioning

confidence: 99%

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

et al. 2015

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“…It has been suggested that there is no association between asthma and wheeze in children ,1 year of age, but it is unclear when that association does appear [5]. It is possible that some turning points do exist at which the incidences of wheeze in asthmatic and nonasthmatic children diverge.…”

Section: Introductionmentioning

confidence: 99%

Early patterns of wheezing in asthmatic and nonasthmatic children

Garcinuño¹,

Gandarillas²

2013

Eur Respir J

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The aim of this study was to describe the time patterns of wheezing in both asthmatic and nonasthmatic children during the first 36 months of life, and to determine whether there are asthma-related breakpoints in the incidence of wheezing.Data from a historical cohort of children followed from birth to 6 years (SLAM cohort) were used. Wheezing episodes until 36 months and asthma at 6 years were both recorded by a doctor. Monthly mean incidence rate of wheezing and rate ratio were calculated. Joinpoint regression models were built to identify breakpoints in the risk of wheeze.Complete information was available for 3739 children. Wheezing in the first 36 months was more frequent in asthmatic than in nonasthmatic children (rate ratio 2.62, 95% CI 1.81-3.78). Differences were appreciable within the first months and increased steadily thereafter because of a persistently high rate in asthmatic children. No breakpoint in the rate ratio could be identified. Asthmatic children exhibited a onephase curve of incidence and nonasthmatic children exhibited a two-phase curve. However, children with allergic asthma also displayed a two-phase curve.There is no identifiable breakpoint during the first 36 months of life at which the incidence of wheezing in asthmatic children begins to stand out. @ERSpublications Increased wheezing in asthmatic children from birth; different progression patterns for allergic and nonallergic asthma

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Early childhood respiratory symptoms and the subsequent diagnosis of asthma

Cited by 79 publications

References 18 publications

Prognosis of wheezing and asthma presenting in early childhood

Prognosis of wheezing and asthma presenting in early childhood

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Early patterns of wheezing in asthmatic and nonasthmatic children

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