Early Choriocapillaris Loss in a Porcine Model of RPE Cell Debridement Precedes Pathology That Simulates Advanced Macular Degeneration

Iezzi, Raymond; Scruggs, Brittni A.; Gandhi, Jarel; Zenti, Francesca N.; Shafi, Noah; Berger, Aubrey; Marmorstein, Alan D.

doi:10.1167/iovs.65.4.8

Cited by 1 publication

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent experiment also showed surgical debridement of the RPE results in GA, choroidal neovascularization, and pachychoroid and reproduced all forms of advanced macular degeneration in female domestic pigs [72]. RPE is closely related to the choriocapillaris and photoreceptor cells, and it seems that the effects of loss of the RPE are immeasurable.…”

Section: Discussion and Limitationsmentioning

confidence: 95%

Drusen in AMD from the Perspective of Cholesterol Metabolism and Hypoxic Response

Ban,

Shinojima,

Negishi

et al. 2024

JCM

View full text Add to dashboard Cite

Drusen are one of the most characteristic pathologies of precursor lesion of age-related macular degeneration (AMD). Drusen comprise a yellowish white substance that accumulates typically under the retinal pigment epithelium (RPE), and their constituents are lipids, complement, amyloid, crystallin, and others. In the past, many researchers have focused on drusen and tried to elucidate the pathophysiology of AMD because they believed that disease progression from early AMD to advanced AMD might be based on drusen or drusen might cause AMD. In fact, it is well established that drusen are the hallmark of precursor lesion of AMD and a major risk factor for AMD progression mainly based on their size and number. However, the existence of advanced AMD without drusen has long been recognized. For example, polypoidal choroidal vasculopathy (PCV), which comprises the majority of AMD cases in Asians, often lacks drusen. Thus, there is the possibility that drusen might be no more than a biomarker of AMD and not a cause of AMD. Now is the time to reconsider the relationship between AMD and drusen. In this review, we focus on early AMD pathogenesis based on basic research from the perspective of cholesterol metabolism and hypoxic response in the retina, and we discuss the role of drusen.

show abstract

Section: Discussion and Limitationsmentioning

confidence: 95%