2016
DOI: 10.1093/eurheartj/ehw112
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Early clinical and echocardiographic outcomes after SAPIEN 3 transcatheter aortic valve replacement in inoperable, high-risk and intermediate-risk patients with aortic stenosis

Abstract: ClinicalTrials.gov #NCT01314313.

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Cited by 322 publications
(151 citation statements)
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“…Second, further technological advances may favorably influence the outcomes with TAVR in the future, and the SAPIEN XT valve that was used in this trial has already been replaced by the SAPIEN 3 valve system. 35,36 Third, in this trial, multislice computed tomography was not used consistently to assess aortic annulus dimensions for appropriate valve sizing. 37 Also, the recent finding of subclinical valveleaflet thrombosis with the use of high-resolution imaging techniques was not systematically evaluated in the current trial.…”
Section: Discussionmentioning
confidence: 99%
“…Second, further technological advances may favorably influence the outcomes with TAVR in the future, and the SAPIEN XT valve that was used in this trial has already been replaced by the SAPIEN 3 valve system. 35,36 Third, in this trial, multislice computed tomography was not used consistently to assess aortic annulus dimensions for appropriate valve sizing. 37 Also, the recent finding of subclinical valveleaflet thrombosis with the use of high-resolution imaging techniques was not systematically evaluated in the current trial.…”
Section: Discussionmentioning
confidence: 99%
“…Further studies should be performed as the field begins to address TAVR in the lower risk patient population who are also at lower risk for GA complications and whose expected outcomes are significantly better than patients treated in these registries. 58,59 Many of the steps of the procedure are primarily guided by fluoroscopy with TEE as an adjunct or confirmatory tool that could reduce fluoroscopic time. Recommendations for intraprocedural TEE imaging throughout TAVR have been extensively reviewed and are summarized in Table 1.…”
Section: Intraprocedural Imaging For Specific Valvular Interventions mentioning
confidence: 99%
“…In addition, newer generation transcatheter heart valves have an outer skirt or adaptive seal, and some systems are even retrievable to optimize the implantation position. These improvements have resulted in low singledigit moderate-to-severe PVL rates in the latest TAVR studies (3,16,17). Due to the proximity between the transcatheter valve frame extending into the left ventricular outflow tract and the conduction system, heart block with need for permanent pacemaker implantation has been frequent after TAVR.…”
mentioning
confidence: 99%