60. Kongress Der Deutschen Gesellschaft Für Pneumologie Und Beatmungsmedizin E. V. 2019
DOI: 10.1055/s-0039-1678326
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Early Clinically Important Improvement (ECII) and Exacerbation Outcomes in the FLAME Study

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“…In summary, CID provides a framework for a potential composite endpoint in young patients, but methodology work is needed to identify the most appropriate components and define appropriate MCID thresholds. Other potential composite endpoints to consider in this population include the Early Clinically Important Improvement (ECII) (148) and COPDCompEx (see above) (149). An alternative to using a composite endpoint would be to jointly model the relevant endpoints that indicate deterioration (150), an approach that has been utilized in oncology trials (151).…”
Section: Composite Endpointsmentioning
confidence: 99%
“…In summary, CID provides a framework for a potential composite endpoint in young patients, but methodology work is needed to identify the most appropriate components and define appropriate MCID thresholds. Other potential composite endpoints to consider in this population include the Early Clinically Important Improvement (ECII) (148) and COPDCompEx (see above) (149). An alternative to using a composite endpoint would be to jointly model the relevant endpoints that indicate deterioration (150), an approach that has been utilized in oncology trials (151).…”
Section: Composite Endpointsmentioning
confidence: 99%