Early Complications in Surgical Treatment of Lung Cancer: A Prospective, Multicenter Study

Duque, J.L.; Ramos, Guillermo; Castrodeza, Javier; Cerezal, Jorge; Castanedo, Manuel; Yuste, Mariano García; Heras, F.

doi:10.1016/s0003-4975(97)00051-9

Cited by 171 publications

(81 citation statements)

References 17 publications

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“…Lung-and urinary tract infections are usually blamed for empyemas seen in the late period. Duque et al reported the rate of postoperative empyema development as 4.4% [13], while Belda et al reported the rate of empyema after lung cancer surgery as 6% [14]. In our study, the rate of postoperative empyema was 3.47%, and the rate of empyema in the cases operated due to a malignancy was 8.1% (8/99).…”

Section: Discussionsupporting

confidence: 44%

Risk Factors in Development of Postoperative Empyema

Özkan¹

2014

Ann Clin Anal Med

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Anahtar KelimelerAmpiyem; Risk Faktörleri; Postoperatif Abstract Aim: Many etiological factors play a role in the occurrence of postoperative empyema. We aimed to define the effects of these factors on the development of empyema. Material and Method: Two hundred and eighty-eight cases from our clinic who underwent tube thoracostomy and/or were operated due to any cause out of the primary empyema between August 2009 and May 2010 were prospectively studied in terms of empyema development. Data comprised gender, age, chemoradiotherapy, surgical procedure, intraoperative thoracic lavage with povidone-iodine, emergency surgery status, sharing the same room with other cases with empyema, primary disease, additional comorbidity, operation duration, drain number, complication, number of patients in the room, and drain discontinuation and hospitalization duration. Blood leukocyte-neutrophil count was ordered in all cases at 3-day intervals, and fluid culture specimens were simultaneously collected from cases with drains. Drainage fluid culture specimens were evaluated with "Automated Identification and Antibiotic Susceptibility Testing" using standard procedures. Empyema cases who developed clinical manifestation and/or with bacterial growth in culture specimens were studied in terms of risk factors. The findings were analyzed using SPSS (version 16). Results: The results showed that gender, age, chemoradiotherapy, surgical procedure, intraoperative thoracic lavage with povidone-iodine, emergency surgery status, and sharing a same room with other empyema cases were not significantly correlated with the risk of empyema development. Contribution of the primary disease (p<0.05), additional comorbidity (p<0.05), operation duration (p<0.05), drain number (p<0.05), complication (p<0.05), number of people in the room (p<0.05), drain discontinuation time (p<0.05) and hospitalization duration (p<0.05) were found to be significant in the development of postoperative empyema. Discussion: Postoperative development of empyema is one of the most serious problems encountered in patients who have undergone tube thoracostomy. Therefore, current risks should be thoroughly assessed in the preoperative period and approaches to minimize these risks should be adopted.

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Section: Discussionsupporting

confidence: 44%

Risk Factors in Development of Postoperative Empyema

Özkan¹

2014

Ann Clin Anal Med

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“…This great variability could be explained by pulmonary disease or by the type of procedure [6 -15]. Studies that reported pulmonary resection for lung cancer had higher mortality rates than other studies [11][12][13][14][15]. In the majority of studies [11][12][13][14][15][16][17][18], the crude mortality rates after major lung resections are still significant: 3% to 12% for pneumonectomy, 3% to 5% for lobectomy, and 1% to 3% for wedge resection, respectively.…”

Section: Commentmentioning

confidence: 99%

Identification of prognostic factors determining risk groups for lung resection

Bernard¹,

Ferrand²,

Hagry³

et al. 2000

The Annals of Thoracic Surgery

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Background. Pulmonary resection belongs to a group of surgical procedures with significant morbidity and mortality. The aims of this study were to classify postoperative complications and to identify prognostic factors determining risk group.Methods. In a prospective study 500 patients undergoing lung resection (wedge resection, n ‫؍‬ 141; lobectomies, n ‫؍‬ 245; bilobectomies, n ‫؍‬ 12; and pneumonectomies, n ‫؍‬ 102) were included. In 178 patients (36%) pulmonary resections were extended to structures or thoracic organs. Sleeve resection of the bronchus to preserve lung parenchyma was performed in 22 patients.Results. Classification of postoperative complications fell into four categories: patients without postoperative complications; patients with moderate complications (n ‫؍‬ 137); patients with severe complications (n ‫؍‬ 38); and death (n ‫؍‬ 33). Factors adversely affecting postoperative complications by multivariate analysis included pulmonary pathology, bronchoplastic technique, forced expiratory volume in 1 second (FEV 1 ), extended resection, type of lung resection, comorbidity indices, and preoperative chemotherapy. Four risk groups were determined. Risk group I (n ‫؍‬ 60) with the best prognosis included patients with FEV 1 greater than or equal to 80%

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“…Informed consent was obtained from all patients. Pneumonia, including nosocomial pneumonia, is one of the main complications occurring in lung cancer patients due to defects in the clearance system in sites peripheral to the bronchial obstruction, or stenosis caused by cancer therapy as well as cancer itself and broad-spectrum antibiotics usage [7][8][9][10][11][12][13][14]. The role of anaerobes in the pathogenesis of pneumonia in hospitalized patients, especially in critically or chronically ill patients, is still controversial [4,15,16].…”

mentioning

confidence: 99%

Anaerobic bacteria colonizing the lower airways in lung cancer patients

Rybojad¹,

Łoś²,

Sawicki³

et al. 2011

Folia Histochem Cytobiol.

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Abstract:Abstract: Abstract: Abstract: Abstract: Anaerobes comprise most of the endogenous oropharyngeal microflora, and can cause infections of airways in lung cancer patients who are at high risk for respiratory tract infections. The aim of this study was to determine the frequency and species diversity of anaerobes in specimens from the lower airways of lung cancer patients. Sensitivity of the isolates to conventional antimicrobial agents used in anaerobe therapy was assessed. Respiratory secretions obtained by bronchoscopy from 30 lung cancer patients were cultured onto Wilkins--Chalgren agar in anaerobic conditions at 37°C for 72-96 hours. The isolates were identified using microtest Api 20A. The minimal inhibitory concentrations for penicillin G, amoxicillin/clavulanate, piperacillin/tazobactam, cefoxitin, imipenem, clindamycin, and metronidazole were determined by E-test. A total of 47 isolates of anaerobic bacteria were detected in 22 (73.3%) specimens. More than one species of anaerobe was found in 16 (53.3%) samples. The most frequently isolated were Actinomyces spp. and Peptostreptococcus spp., followed by Eubacterium lentum, Veillonella parvula, Prevotella spp., Bacteroides spp., Lactobacillus jensenii. Among antibiotics used in the study amoxicillin/clavulanate and imipenem were the most active in vitro (0% and 2% resistant strains, respectively). The highest resistance rate was found for penicillin G and metronidazole (36% and 38% resistant strains, respectively). The results obtained confirm the need to conduct analyses of anaerobic microflora colonizing the lower respiratory tract in patients with lung cancer to monitor potential etiologic factors of airways infections, as well as to propose efficient, empirical therapy. (Folia Histochemica et

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Early Complications in Surgical Treatment of Lung Cancer: A Prospective, Multicenter Study

Cited by 171 publications

References 17 publications

Risk Factors in Development of Postoperative Empyema

Risk Factors in Development of Postoperative Empyema

Identification of prognostic factors determining risk groups for lung resection

Anaerobic bacteria colonizing the lower airways in lung cancer patients

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