Early complications of prematurity

Voinescu, Mariana; Bălaşa, A; Mihai, Cristina Maria; Cuzic, Viviana; Mihai, Larisia; Frecus, Corina Elena; Stroia, Valeria; Stoicescu, R

doi:10.1016/j.earlhumdev.2008.09.115

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Short-chain carbohydrates that are indigestible by humans but are fermentable by some microbes have demonstrable efficacy in increasing the populations of Lactobacilli and Bifidobacteria in the human gastrointestinal tract (Wang and Gibson, 1993). Investigations of galactose oligosaccharides (GOS) and fructose oligosaccharides (FOS) as additives to infant formula have demonstrated increased Bifidobacterial populations, decreased stool pH, generation of a stool fatty acid profile more similar to that found in breastfed infants, and reduced populations of potential pathogens such as Clostridia spp., Bacteroides spp., and E. coli (Fanaro et al, 2005; Knol et al, 2005; Costalos et al, 2008; Magne et al, 2008; Rao et al, 2009). Prebiotic supplementation with oligosaccharides may promote blooms of beneficial bacteria more effectively than direct administration of pro-biotic organisms: a study directly comparing infant formula containing Bifidobacterium animalis with GOS/FOS-supplemented formula revealed a significantly greater proportion of Bifidobacterial species in the infants fed oligosaccharide-containing formula but no difference between the Bifidobacterial supplemented formula and control formula groups (Bakker-Zierikzee et al, 2005).…”

Section: Functional Metagenomics For Refining Pre- and Pro-biotic Intmentioning

confidence: 99%

Functional Metagenomic Investigations of the Human Intestinal Microbiota

Moore¹,

Munck²,

Sommer³

et al. 2011

Front. Microbio.

View full text Add to dashboard Cite

The human intestinal microbiota encode multiple critical functions impacting human health, including metabolism of dietary substrate, prevention of pathogen invasion, immune system modulation, and provision of a reservoir of antibiotic resistance genes accessible to pathogens. The complexity of this microbial community, its recalcitrance to standard cultivation, and the immense diversity of its encoded genes has necessitated the development of novel molecular, microbiological, and genomic tools. Functional metagenomics is one such culture-independent technique, used for decades to study environmental microorganisms, but relatively recently applied to the study of the human commensal microbiota. Metagenomic functional screens characterize the functional capacity of a microbial community, independent of identity to known genes, by subjecting the metagenome to functional assays in a genetically tractable host. Here we highlight recent work applying this technique to study the functional diversity of the intestinal microbiota, and discuss how an approach combining high-throughput sequencing, cultivation, and metagenomic functional screens can improve our understanding of interactions between this complex community and its human host.

show abstract