Early creatinine and e-GFR changes as prognostic predictors of COVID-19 patients

Abstract

Objectives We aimed to investigate the effects of the COVID-19 disease on kidney functions and early prognosis. Materials and Methods All cases were divided into those discharged and exitus cases. The patients were diagnosed with acute kidney injury (AKI) according to the KDIGO criteria. Results As a result of the ROC analysis, the patients with a creatinine value above 1.05 for day 1 and 0.975 for creatinine value on day 7 would be mortal (AUC values of 0.641 (0.569–0.714) and 0.757 (0.689–0.825), respectively). As a result of Univariate analysis; D-Dimer, Procalcitonin, BUN and creatinine values are risk factors and a one-unit increase in these values is 1.184; 1.105; It was determined that it would increase 1.024 and 1.304 times (p values 0.008; 0.007; <0.001; 0.002), respectively. Decreased in e-GFR value would increase the risk of death 1.026 (1/0.975) times (p<0.001). Conclusions We observed the high creatinine, D-dimer, procalcitonin, ferritin, and low e-GFR levels were risk factors for severity and mortality for COVID-19 disease. While physicians and all stakeholders focus on the prognosis and mortality of the disease of COVID-19 disease, it is necessary to be thorough about kidney involvement as much as respiratory system involvement.

Demographic and clinical characteristics and outcomes of COVID-19 patients admitted to a university hospital in the west of Iran: a retrospective study in the third wave

“…This finding was consistent with previous reports of higher plasma glucose and creatinine levels in critically ill COVID-19 patients. ( 21 , 22 ).…”

The value of prospective metabolomic susceptibility endotypes: broad applicability for infectious diseases

“…Furthermore, we observed significant elevations of phenotypes related to kidney function for the severe endotype, with average levels of both creatinine and BUN in the abnormal range, suggesting an initial tendency toward kidney dysfunction among these individuals. 45 , 46 Vitamin D is known to play a critical role in immunomodulation; sufficient levels are therefore particularly important for IDs like COVID-19 and influenza. 47 , 48 Consistent with this finding, we identified that average levels of vitamin D were insufficient among the severe endotype resulting in further susceptibility.…”