Early detection of a hypervirulent KPC-2-producing Pseudomonas aeruginosa ST235 in Brazil

Paula-Petroli, Suelen Balero de; Campana, Eloiza Helena; Bocchi, Mayara; Bordinhão, Thiago; Picão, Renata Cristina; Yamada‐Ogatta, Sueli Fumie; Carrara-Marroni, Floristher Elaine

doi:10.1016/j.jgar.2018.01.014

Cited by 11 publications

(9 citation statements)

References 5 publications

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“…Cavalcanti et al 39 described the dissemination of the blaKPC gene in two isolates belonging to clone ST235 and one isolate from clone ST244. Similar data were reported by Petroli et al 34 who reported the occurrence of the blaKPC gene in an isolate of clone ST235. Interestingly, this strain was isolated from UTIs in 2008, long before the publication of the first report of this gene in P. aeruginosa in Brazil, which occurred in 2012.…”

Section: Discussionsupporting

confidence: 90%

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Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil

2022

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Pseudomonas aeruginosa is one of the main microorganisms causing healthcare-related infections. The rise of carbapenem-resistant P. aeruginosa (CRPA) strains has become a serious public health problem. Dissemination of the enzyme Klebsiella pneumoniae carbapenemase (KPC) encoded by the blaKPC gene cause the inactivation of β-lactam antibiotics being one of the mechanisms involved in this resistance. Given the above, the objective of this review was to evaluate the occurrence of the blaKPC gene in clinical isolates of P. aeruginosa in Brazil. For this, the online databases used were: Lilacs, SciELO and PubMed. The search for articles included articles published from 2012 to 2020, using the following keywords: blaKPC (KPC), Pseudomonas aeruginosa, and Brazil (in Portuguese and English). Initially, 30 publications eligible for inclusion in this review were identified. After the first analysis, two articles were excluded due to duplication. Subsequently, titles and abstracts were evaluated, 15 articles were excluded because they did not fit the theme, and 13 articles that met the inclusion criteria were read in full. In these studies, the presence of the blaKPC gene was investigated in 566 clinical isolates of P. aeruginosa in Brazil, with 86 (15.2%) positive samples found. Pernambuco was the state with the highest number of articles and positive samples, respectively, 38.5% (5/13), and 65.1% (56/86). This study reinforces the need to investigate the occurrence of this gene in all regions of the country in CRPA, aiming to understand how its dissemination occurs and to promote prevention and therapeutic strategies.

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Section: Discussionsupporting

confidence: 90%

“…After this stage, 13 studies met the inclusion criteria and moved on to the next stage where the articles were read in full, as can be seen in the flowchart, Figure 1. Table 1 presents the main results found in these studies [30][31][32][33][34][35][36][37][38][39][40] .…”

Section: Resultsmentioning

confidence: 99%

Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil

2022

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“…In this study, bla KPC-2 was detected in a single P. aeruginosa isolate collected in São Paulo, as observed previously in some medical centers. 26 , 27 , 28 , 29 , 30 In addition, a few MBL-producing P. aeruginosa isolates were detected in our study. SPM-1-producing P. aeruginosa ST277, an MBL producer clone, was widely disseminated in Brazilian hospitals in the 2000s.…”

Section: Discussionsupporting

confidence: 49%

Activity of ceftolozane-tazobactam and comparators against gram-negative bacilli: Results from the study for monitoring antimicrobial resistance trends (SMART – Brazil; 2016–2017)

Beirão¹,

Rodrigues

Andrade

et al. 2020

The Brazilian Journal of Infectious Diseases

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“…The 53 studies included in this review were conducted in American, European, and Asian countries. China (14 studies) [ 14 , 15 , 17 , 19 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ], Brazil (10 studies) [ 21 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ], and Colombia (9 studies) [ 22 , 26 , 27 , 28 , 29 , 51 , 52 , 53 , 54 ] were the countries with the most reported studies, followed by Puerto Rico (4 studies) [ 55 , 56 , 57 , 58 ], Chile (2 studies) [ 59 , 60 ], Argentina (2 studies) [ 61 , 62 ], Vietnam (1 study) [ 63 ], Trinidad and Tobago (1 study) [ 64 ], Nepal (1 study) [ 65 ], India (1 study) [ 66 ], Germany (1 study) [ 18 ], Spain (1 study) [ 6 ], and the USA (1 study) […”

Section: Resultsmentioning

confidence: 99%

Worldwide Dissemination of blaKPC Gene by Novel Mobilization Platforms in Pseudomonas aeruginosa: A Systematic Review

et al. 2023

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The dissemination of blaKPC-harboring Pseudomonas aeruginosa (KPC-Pa) is considered a serious public health problem. This study provides an overview of the epidemiology of these isolates to try to elucidate novel mobilization platforms that could contribute to their worldwide spread. A systematic review in PubMed and EMBASE was performed to find articles published up to June 2022. In addition, a search algorithm using NCBI databases was developed to identify sequences that contain possible mobilization platforms. After that, the sequences were filtered and pair-aligned to describe the blaKPC genetic environment. We found 691 KPC-Pa isolates belonging to 41 different sequence types and recovered from 14 countries. Although the blaKPC gene is still mobilized by the transposon Tn4401, the non-Tn4401 elements (NTEKPC) were the most frequent. Our analysis allowed us to identify 25 different NTEKPC, mainly belonging to the NTEKPC-I, and a new type (proposed as IVa) was also observed. This is the first systematic review that consolidates information about the behavior of the blaKPC acquisition in P. aeruginosa and the genetic platforms implied in its successful worldwide spread. Our results show high NTEKPC prevalence in P. aeruginosa and an accelerated dynamic of unrelated clones. All information collected in this review was used to build an interactive online map.

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Early detection of a hypervirulent KPC-2-producing Pseudomonas aeruginosa ST235 in Brazil

Cited by 11 publications

References 5 publications

Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil

Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil

Activity of ceftolozane-tazobactam and comparators against gram-negative bacilli: Results from the study for monitoring antimicrobial resistance trends (SMART – Brazil; 2016–2017)

Worldwide Dissemination of blaKPC Gene by Novel Mobilization Platforms in Pseudomonas aeruginosa: A Systematic Review

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