Early Detection of Advanced Adenomas and Colorectal Carcinoma by Serum Glycoproteome Profiling

Desai, Khushbu; Gupta, Samir; May, Folasade P.; Xu, Gege; Shaukat, Aasma; Hommes, Daniel W.; Ding, Nik Sheng; Rice, Rachel; Cong, Xin; Schwarz, Flavio; Serie, Daniel; Wallace, Michael B.; Aguilar, Humberto; Brown, Colin C.; Clark, Larry E.; Dang, Long; Hellstern, Paul A.; Kimberly, James R.; Lankarani, Ali; Misra, Bharat K.; Nguyen, Hoa; Pineau, Benoit C.; Siegel, Jonathan D.; Trawick, Eric P.

doi:10.1053/j.gastro.2023.09.034

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…Among the various avenues of molecular investigation, proteomic methodologies have emerged as crucial tools in unraveling the intricate molecular landscape of colorectal cancer and identifying biomarkers for precise diagnostics and targeted therapies. 50 One of the fundamental proteomic techniques employed in the study of colorectal cancer is mass spectrometry (MS). MS enables the high-throughput identification and quantification of proteins, offering a comprehensive view of the proteome.…”

Section: Molecular Profiling Of Colorectal Cancermentioning

confidence: 99%

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Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Section: Molecular Profiling Of Colorectal Cancermentioning

confidence: 99%

Section: Molecular Profiling Of Colorectal Cancermentioning

confidence: 99%

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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“…This will shed light on the glycoprotein(s) and glycosylation site(s) that contribute to the observed TBNG signatures. The disease glycoproteomics studies of InterVenn Biosciences have already demonstrated that such glycoproteomic studies can match or outperform released glycan glycomic studies with respect to clinical biomarker potential …”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…The disease glycoproteomics studies of InterVenn Biosciences have already demonstrated that such glycoproteomic studies can match or outperform released glycan glycomic studies with respect to clinical biomarker potential. 107 While current glycoproteomic workflows do provide site-and protein-specific information on glycosylation, they fail to reveal key glycosylation features such as sialic acid linkages and often ambiguous features such as core fucosylation and bisection. Future development of glycoproteomics workflows with inclusion of ion mobility spectroscopy and improvements in MS/MS data interpretation are warranted to enhance the definition of glycan structures from bottom-up glycopeptidebased analyses.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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The Human Blood N-Glycome: Unraveling Disease Glycosylation Patterns

Pongracz,

Mayboroda,

Wuhrer

2024

JACS Au

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Most of the proteins in the circulation are Nglycosylated, shaping together the total blood N-glycome (TBNG). Glycosylation is known to affect protein function, stability, and clearance. The TBNG is influenced by genetic, environmental, and metabolic factors, in part epigenetically imprinted, and responds to a variety of bioactive signals including cytokines and hormones. Accordingly, physiological and pathological events are reflected in distinct TBNG signatures. Here, we assess the specificity of the emerging disease-associated TBNG signatures with respect to a number of key glycosylation motifs including antennarity, linkagespecific sialylation, fucosylation, as well as expression of complex, hybrid-type and oligomannosidic N-glycans, and show perplexing complexity of the glycomic dimension of the studied diseases. Perspectives are given regarding the protein-and site-specific analysis of N-glycosylation, and the dissection of underlying regulatory layers and functional roles of blood protein N-glycosylation.

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Potential of Serum Glycoproteome Profiling in Prediction of Advanced Adenomas and Colorectal Carcinoma: Individual Heterogeneity Should Be Taken Into Account

Qu,

Zhang,

2024

Gastroenterology

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Early Detection of Advanced Adenomas and Colorectal Carcinoma by Serum Glycoproteome Profiling

Cited by 4 publications

References 6 publications

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

The Human Blood N-Glycome: Unraveling Disease Glycosylation Patterns

Potential of Serum Glycoproteome Profiling in Prediction of Advanced Adenomas and Colorectal Carcinoma: Individual Heterogeneity Should Be Taken Into Account

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