Early Detection of Apoptosis and Fas Ligand Expression in Hepatic Graft-versus-Host Disease after Rat Small Bowel Transplantation

Shiraishi, Masayuki; Hiroyasu, Shungo; Oshiro, Takashi; Nagahama, Masayoshi; Tomori, Hirofumi; Mamadi, Toure; Muto, Yoshihiro

doi:10.1006/jsre.1999.5706

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…For example, fasL-fas mediated signals appear to be particularly important in GVH associated liver damage, consistent with the high level expression of fas in hepatic tissue [76,78,79,[241][242][243]. Regulation of key cytokines and other effector molecules found to be more contributory in a single -or subset of target tissues may provide additional venues for the 'regional' regulation and control of anti-host effector cell responses.…”

Section: Regulation Of Gvhd: Stagementioning

confidence: 81%

GVHD: Complication and Challenge to Successful Allogeneic Hematopoietic Cell Transplantation

Levy

2005

CMCIEMA

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Graft vs. host disease (GVHD) represents the major obstacle to more widespread clinical application of allogeneic hematopoietic cell transplants and experimentally provides perhaps the most important model for immunologists to study the significance and regulation of allogeneic T cell responses in situ. The sensitivity of induction to donor T cell numbers, the target tissues 'attacked' in the host and the clinical sequelae associated with the pathogenesis of GVHD in the mouse remarkably parallel that which occurs in humans and thus has provided an extremely useful tool to dissect the underlying cells and mechanisms involved in this complex disorder. This review describes the general features of GVHD followed by a description of the three stages which define this response. Approaches being developed to regulate experimental as well as clinical GVHD during these different stages are then discussed. We conclude that advances towards the targeting of each stage of the process are raising hope that clinicians will one day be able to control both the 'light' and 'dark' sides of GVHD. The challenge to refine and implement such approaches at the bedside necessitates continued interactions and collaborative efforts between laboratories dedicated to applying the underlying cellular and molecular biology of hematolymphoid cells to transplantation together with clinician scientists motivated by the goal to perform hematopoietic cell transplants without fear of complications.

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Section: Regulation Of Gvhd: Stagementioning

confidence: 81%

GVHD: Complication and Challenge to Successful Allogeneic Hematopoietic Cell Transplantation

Levy

2005

CMCIEMA

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Adenovirus-mediated gene transfer of Bcl-2 in graft-versus-host disease after rat intestinal transplantation

Shiraishi¹,

Taira²,

Sugawa³

et al. 2000

Transplantation Proceedings

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Intraepithelial lymphocyte-derived interferon-γ evokes enterocyte apoptosis with parenteral nutrition in mice

Yang

Fan

Teitelbaum

2003

American Journal of Physiology-Gastrointestinal and Liver Physi

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Total parenteral nutrition (TPN) results in an increase in intraepithelial lymphocyte (IEL)-derived interferon-gamma (IFN-gamma) expression as well as an increase in epithelial cell (EC) apoptosis. This study examined the role that IEL-derived IFN-gamma has in the increase in EC apoptosis. Mice received either TPN or oral feedings for 7 days. Small bowel EC apoptosis significantly rose in mice receiving TPN. The administration of TPN also significantly increased IEL-derived IFN-gamma and Fas ligand (FasL) expression. EC apoptosis in IFN-gamma knockout (IFNKO) mice that received TPN was significantly lower than in wild-type TPN mice. Sensitivity of EC to Fas-mediated apoptosis in IFNKO mice was significantly lower than in wild-type TPN mice. Apoptosis in Fas-deficient and FasL-deficient mice that received TPN was significantly lower than in wild-type mice that received TPN. The TPN-induced increase in IFN-gamma expression appears to result in an increase in Fas-L expression and EC sensitivity to Fas, with a resultant increase in EC apoptosis. This may well be one of the mediators of increased EC apoptosis observed with TPN administration.

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Early Detection of Apoptosis and Fas Ligand Expression in Hepatic Graft-versus-Host Disease after Rat Small Bowel Transplantation

Cited by 3 publications

References 31 publications

GVHD: Complication and Challenge to Successful Allogeneic Hematopoietic Cell Transplantation

GVHD: Complication and Challenge to Successful Allogeneic Hematopoietic Cell Transplantation

Adenovirus-mediated gene transfer of Bcl-2 in graft-versus-host disease after rat intestinal transplantation

Intraepithelial lymphocyte-derived interferon-γ evokes enterocyte apoptosis with parenteral nutrition in mice

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