Early Detection of Busulfan Lung. Report of a Case

Fatal pneumothorax in “BCNU lung”

“…The Occurrence of pneumothorax in patients receiving BCNU should raise the possibility of drug-induced interstitial lung disease. Further investigations with pulmonary function tests including diffusing capacity for carbon monoxide (DLco) and gallium 67 scanning may reveal abnormalities before there are radiological changes on chest X-ray [7]. Reported responses of "BCNU lung" to prednisone therapy have varied from complete recovery to dose-dependent improvement, but most patients show no response and die with respiratory failure.…”

Clinical Approach to the Compromised Host with Fever and Pulmonary Infiltrates

“…A total dose of 340 mg had been alveolar fibrosis and large atypical alveolar mononuclear cells may be seen in a much higher percentage of patients receiving chronic busulfan therapy. [166][167][168][169] Figure 4 demonstrates the typical radiologic findings in a patient with this form of lung injury.…”