Early detection of cancer therapy cardiotoxicity by radionuclide angiography: An update

Early prediction of chemotherapy-induced cardiotoxicity

“…Although the number of studies published in this area is limited, there is a vast amount of underutilized information from RNA images that has potential to predict outcomes, particularly when combined with LVEF. The paper by Valzania et al 5 in this edition of the journal reviews the potential for RNA derived parameters to predict CTRCD. The parameters discussed include peak filling rate, time to peak filling rate and approximate entropy.…”

“…14 There is evidence that a change in GLS precedes LVEF decline and as a result, it has been included in the ESC guidelines. 4 A 15% decrease in GLS from baseline is considered significant, but as highlighted by Valzania et al, 5 there's currently no consensus on whether an asymptomatic GLS decrease should be used to guide treatment. The recent SUC-COUR multicenter trial data provides additional evidence in support of GLS for cardiac monitoring.…”

“…In summary, RNA imaging may be able to predict CTRCD but there is not yet enough evidence behind it. The paper by Valzania et al 5 summarizes the research to date and highlights the work that needs to be carried out to fully investigate the potential of RNA for predicting CTRCD. The results of larger multi-center trials are needed to determine the predictive value of the parameters discussed and establish a normal range.…”