Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature

Thipsawat, Sopida

doi:10.1177/14791641211058856

Cited by 118 publications

(57 citation statements)

References 63 publications

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“…Ren et al [ 16 ] found that inflammatory factors such as interleukin (IL)-6, hypersensitive c-reactive-protein (hs-CRP), and tumor necrosis factor- α (TNF- α ) in patients with diabetic nephropathy accelerated the renal vascular sclerosis lesions in the body, which reduces the vascular elasticity and stimulates the proliferation of glomerular thylakoid cells in the body, thereby aggravating the disease. Thipsawat et al [ 17 ] stated that the control of inflammatory response and proteinuria in patients with diabetic nephropathy contributed to the alleviation of impaired renal function in patients. Vlachou et al [ 18 ] demonstrated that effective nursing interventions in patients with diabetic nephropathy treated with hemodialysis mitigated the inflammatory response and improved the patient's prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Effects of Primary Nursing on Diabetic Nephropathy Patients Undergoing Hemodialysis and Its Impact on the Inflammatory Responses

Guo¹,

Qin²,

Cui³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To assess the clinical effects of primary nursing on diabetic nephropathy patients undergoing hemodialysis and its impact on inflammatory responses. Methods. Between July 2019 and April 2021, 80 patients with diabetic nephropathy who underwent hemodialysis in our institution were recruited and assigned at a ratio of 1 : 1 to receive either routine nursing (routine group) or primary nursing (primary group). The outcome measures included nursing outcomes, inflammatory factor levels, and psychological status. Results. Primary nursing resulted in lower levels of blood creatinine, fasting glucose, urea nitrogen, and proteinuria versus routine nursing ( P < 0.05 ). Patients receiving primary nursing showed significantly lower levels of interleukin (IL)-6, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-alpha (TNF-α) versus those given routine nursing ( P < 0.05 ). The patients in the primary group had significantly lower scores on the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) versus those in the routine group ( P < 0.05 ). Conclusion. Primary nursing improves the renal function of diabetic nephropathy patients undergoing hemodialysis, reduces the inflammatory response, and eliminates their negative emotions, which shows great potential for clinical application.

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Section: Discussionmentioning

confidence: 99%

Clinical Effects of Primary Nursing on Diabetic Nephropathy Patients Undergoing Hemodialysis and Its Impact on the Inflammatory Responses

Guo¹,

Qin²,

Cui³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Abnormalities in pulmonary ventilation and diffusion function are associated with the development of DN [ 20 ]. DN poses a significant impairment of the pulmonary function indicators FEV1 and FVC, and this impairment is significantly associated with an increased rate of abnormal proteinuria (urinary protein/urinary creatinine ratio) [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Diabetic Nephropathy on Pulmonary Function and Clinical Outcomes

Niu

Liu

Yang

et al. 2022

Computational Intelligence and Neuroscience

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Objective. The main objective is to study the effect of diabetic nephropathy on pulmonary function and clinical outcomes. Methods. The method is to retrospectively analyze patients with diabetic nephropathy (DN) in our hospital from April 2018 to March 2022 as study subjects. The differences in baseline data, serum indicators, renal function indicators, and pulmonary function of patients at different clinical stages were analyzed and then explored. Finally, logistic regression was used to analyze the risk factors affecting patients’ clinical outcomes and to evaluate the diagnostic effects. Results. Baseline information (age, disease duration, BMI, and systolic and diastolic blood pressure), serum indicators (HbA1c, FBG, 2hPG, TG, TC, and LDLC), renal function indicators (CysC, BUN, and Scr), and pulmonary function (TLC, VC, FEV1, FEV1/FVC, MVV, MEF25, MEF50 MEF75, DLCO, and DLCO/VA) were significantly different P < 0.01 ; multiple logistic regression analysis showed that SBP, HbA1c, FBG, 2hPG, BUN, Scr, TLC, VC, FEV1/FVC, MVV, DLCO, and DLCO/VA were all key factors in the development of clinical outcomes in DN P < 0.05 . ROC analysis showed that all of these important factors had an AUC greater than 0.75 for the diagnosis of DN with high sensitivity and specificity. Conclusion. Serum and renal function indices of DN patients gradually increased with stage, accompanied by a decrease in pulmonary ventilation, and diffusion function; SBP, HbA1c, FBG, 2hPG, BUN, Scr, TLC, VC, FEV1/FVC, MVV, DLCO, and DLCO/VA were all key factors affecting the clinical outcome of DN; controlling blood glucose, lipids, improving pulmonary ventilation, and diffusion function can better prevent the occurrence and worsening of DN.

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“…Examples of biomarkers are proteins, lipids, microRNAs, genomic, etc. Plenty of biomarkers associated with DKD were found in recent years, such as serum cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and serum homocysteine (Hcy) [12].…”

Section: Introductionmentioning

confidence: 99%

Serum Adiponectin Level in Different Stages of Type 2 Diabetic Kidney Disease: A Meta-Analysis

Shi

Wang³

2022

Computational and Mathematical Methods in Medicine

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Background. Biomarkers in predicting the stages of nephropathy associated with type 2 diabetes mellitus are urgent, and adiponectin may be a promising biomarker. This meta-analysis examined the association of serum adiponectin level with the stages of type 2 diabetic nephropathy. Methods. Databases including PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), and Wan Fang were searched for published studies on adiponectin and type 2 diabetic kidney disease. The Newcastle-Ottawa scale was used to assess the quality of the literature. STATA 14.0 was used to conduct the statistical analysis. Results. Thirty-four studies with 5254 patients were included in this meta-analysis. The results of this study show that there was no significant difference in serum adiponectin level between normoalbuminuria and the control group ( mean difference = − 0.42 , 95% CI [-1.23, 0.40]), while serum adiponectin level was positively correlated with the severity of type 2 diabetic kidney disease. The serum adiponectin level in type 2 diabetic kidney disease patients ranks as macroalbuminuria > microalbuminuria > normoalbuminuria . Conclusions. Serum adiponectin level might be an important marker to predict the progression of type 2 diabetic kidney disease.

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Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature

Cited by 118 publications

References 63 publications

Clinical Effects of Primary Nursing on Diabetic Nephropathy Patients Undergoing Hemodialysis and Its Impact on the Inflammatory Responses

Clinical Effects of Primary Nursing on Diabetic Nephropathy Patients Undergoing Hemodialysis and Its Impact on the Inflammatory Responses

Impact of Diabetic Nephropathy on Pulmonary Function and Clinical Outcomes

Serum Adiponectin Level in Different Stages of Type 2 Diabetic Kidney Disease: A Meta-Analysis

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