Early Detection of Endolymphatic Hydrops using the Auditory Nerve Overlapped Waveform (ANOW)

Lee, Choongheon; Valenzuela, Carla V.; Goodman, Shawn S.; Kallogjeri, Dorina; Buchman, Craig A.; Lichtenhan, Jeffery T.

doi:10.1016/j.neuroscience.2019.11.004

Cited by 19 publications

(27 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OAEs provide noninvasive, frequency-specific objective measures of cochlear mechanical sensitivity 11 , 12 . These hearing-threshold and OAE results are similar to those we reported previously from other guinea pigs with endolymphatic hydrops 8 , 9 . It is interesting that similar OAE results were obtained from a patient with Ménière’s disease 12 .…”

Section: Resultssupporting

confidence: 91%

“…We created an animal model of endolymphatic hydrops by ablating the endolymphatic sac 7 . At 30 days after the operation, operated ears had normal hearing thresholds at high frequencies and a hearing loss at low frequencies 8 , 9 , a pattern found in early-stage Ménière’s disease 3 . By using a cochlear perfusion technique that enables assessment of tonotopicity 10 , 11 , we show, for the first time, abnormal cochlear frequency-place maps in ears that developed normally but have been changed by a disease process (endolymphatic hydrops).…”

Section: Introductionmentioning

confidence: 86%

“…Here we provide brief information on sound presentation and calibration, but details can be found in our previous publications 8 – 10 . A 1/8″ reference microphone (GRAS type 40P) and custom-made coupling system was used to set stimulus levels in the guinea pig ears.…”

Section: Methodsmentioning

confidence: 99%

“…Method details for neural measurements have been described 8 , 9 , 11 . Briefly, neural measurements (e.g.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Altered mapping of sound frequency to cochlear place in ears with endolymphatic hydrops provide insight into the pitch anomaly of diplacusis

Guinan

Lefler

Buchman

et al. 2021

Sci Rep

View full text Add to dashboard Cite

A fundamental property of mammalian hearing is the conversion of sound pressure into a frequency-specific place of maximum vibration along the cochlear length, thereby creating a tonotopic map. The tonotopic map makes possible systematic frequency tuning across auditory-nerve fibers, which enables the brain to use pitch to separate sounds from different environmental sources and process the speech and music that connects us to people and the world. Sometimes a tone has a different pitch in the left and right ears, a perceptual anomaly known as diplacusis. Diplacusis has been attributed to a change in the cochlear frequency-place map, but the hypothesized abnormal cochlear map has never been demonstrated. Here we assess cochlear frequency-place maps in guinea-pig ears with experimentally-induced endolymphatic hydrops, a hallmark of Ménière’s disease. Our findings are consistent with the hypothesis that diplacusis is due to an altered cochlear map. Map changes can lead to altered pitch, but the size of the pitch change is also affected by neural synchrony. Our data show that the cochlear frequency-place map is not fixed but can be altered by endolymphatic hydrops. Map changes should be considered in assessing hearing pathologies and treatments.

show abstract

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

“…Method details for neural measurements have been described 8 , 9 , 11 . Briefly, neural measurements (e.g.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Altered mapping of sound frequency to cochlear place in ears with endolymphatic hydrops provide insight into the pitch anomaly of diplacusis

Guinan

Lefler

Buchman

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…One of the ECochG applications includes enhancement of auditory brainstem response (ABR) wave I, helping with diagnosis of auditory neuropathy spectrum disorder, the study of cochlear synaptopathy, and endolymphatic hydrops that is associated with Meniere's disease, assessing the efferent auditory system, as well as monitoring the status of the cochlea and auditory nerve intraoperatively. [1][2][3][4][5][6] Enlarged summating potential/action potential (-SP/AP) amplitude and area ratios in the ECochG measurements have been supplemental in the diagnosis of Meniere's disease [7][8][9][10][11] and found in ears suspected of having cochlear synaptopathy. 12,13 Studies have found that the simultaneous recording of ECochG and ABR mediate a clearer view of ABR wave I (i.e., the AP) compared with a scalp-only electrode configuration.…”

mentioning

confidence: 99%

Comparing Simultaneous Electrocochleography and Auditory Brainstem Response Measurements Using Three Different Extratympanic Electrodes

2021

View full text Add to dashboard Cite

Background Various extratympanic recording electrodes have been used to make electrocochleography (ECochG) and auditory brainstem response (ABR) measurements in clinics, translational research, and basic science laboratories. However, differences may exist in ECochG and ABR measurements depending on the different types of extratympanic electrodes that are used. Purpose The purpose of this research is to compare simultaneously recorded ECochG and ABR responses using three different extratympanic electrodes. This research helps clinicians and researchers to understand how electrode types and recording sites influence EcochG and ABR results. In addition, our findings could provide more normative data to the ECochG and ABR literature as well as give perspective on a preferred electrode approach when performing simultaneous ECochG and ABR testing. Research Design Ours was a repeated-measures study with measurements being made from individual participants on two separate sessions. Study Sample Twenty young adult females with normal hearing. Procedure A three-channel recording system was used to simultaneously record ECochG and ABR measurements in response to alternating polarity click stimuli. In each session, measurements were simultaneously recorded with a TipTrode electrode and one of the tympanic membrane (TM) electrodes. Data Collection and Analysis Suprathreshold summating potential (SP) and action potential (AP) of the ECochG and waves I, III, and V of the ABR, and threshold responses (AP and wave V) were identified. Results Compared with the ear canal TipTrode electrode, TM electrodes yielded suprathreshold amplitudes that were larger than those from the ear canal electrode, smaller SP–AP ratios, lower AP thresholds, and less variability. These findings can help guide choices made by clinicians, translational investigators, and basic science researchers on which type of extra-tympanic electrode to use for their intended purpose.

show abstract

Meniere's disease: Structural considerations in early cochlea hydrops

Pender

2024

Laryngoscope Investig Oto

View full text Add to dashboard Cite

ObjectiveStructural features of the human cochlea may control early lesion formation in endolymphatic hydrops. This process may hinge on three structural features: the flattened spiral shape of the human cochlea, the toroidal configuration of the distended cochlea duct, and the distensibility characteristics of Reissner's membrane. An analytical method is presented to assess the variation in hydropic distention that may occur in the several turns of the cochlea due to these structural features.MethodsA normal human cochlea is used to illustrate the method of analysis. Structural dimensions were taken from a mid‐modiolar section. Reissner's membrane was projected to assume a spiral toroid shape as it distends. Peak membrane stress proclivities in each cochlea turn were calculated analytically. Membrane strain was assessed from a collagen model of Reissner's membrane. Sagittal membrane displacements were quantified geometrically.ResultsStress levels in Reissner's membrane were projected to be the lowest in the lower basal turn and to increase progressively to a peak value in the apex. Strain in Reissner's membrane in the apical turn was projected to be substantially higher than in the lower turns. Sagittal displacement of Reissner's membrane was projected to be most pronounced in the apical turn in all the stages of early cochlea hydrops.ConclusionStructural features appear to underlie a differential susceptibility to hydrops in the human cochlea. The flattened spiral shape of the human cochlea coupled with the anticlastic configuration and the distensile characteristics of Reissner's membrane are projected to result in distinct histological stages as hydropic disease in the cochlea progresses.

show abstract

Early Detection of Endolymphatic Hydrops using the Auditory Nerve Overlapped Waveform (ANOW)

Cited by 19 publications

References 55 publications

Altered mapping of sound frequency to cochlear place in ears with endolymphatic hydrops provide insight into the pitch anomaly of diplacusis

Altered mapping of sound frequency to cochlear place in ears with endolymphatic hydrops provide insight into the pitch anomaly of diplacusis

Comparing Simultaneous Electrocochleography and Auditory Brainstem Response Measurements Using Three Different Extratympanic Electrodes

Meniere's disease: Structural considerations in early cochlea hydrops

Contact Info

Product

Resources

About