Early Detection of Left Ventricular Contractility Abnormalities by Two‐Dimensional Speckle Tracking Strain in Chagas' Disease

Barbosa, Márcia M.; Rocha, Manoel Otávio Costa; Vidigal, Daniel Furtado; Carneiro, Renata de Carvalho Bicalho; Araújo, Rafaela Drumond; Palma, Mariana Campos; Barros, Márcio Vinícius Lins; Nunes, Maria Carmo Pereira

doi:10.1111/echo.12426

Cited by 50 publications

(68 citation statements)

References 32 publications

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“…However, these measurements have major disadvantages, including angle dependence, limited spatial resolution, and deformation analysis in one dimension [9]. Two-dimensional (2D) speckle tracking echocardiography (STE) is a more effective method for objectively evaluating both the systolic and diastolic functions of the myocardium in detail [9][10][11]. STE assessment might be useful for identifying patients with subclinical LV dysfunction when the LV ejection fraction (LVEF) is normal on conventional echocardiography [12,13].…”

Section: Introductionmentioning

confidence: 99%

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Demirelli¹,

Değirmenci²,

Ermis³

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is characterized by hormonal and metabolic abnormalities and is thought to increase a risk for cardiovascular diseases. In this study we use speckle tracking echocardiography (STE) to evaluate left ventricular (LV) dysfunction in the early period of the disease. We enrolled 31 patients with PCOS and 32 healthy volunteers as a control group. The participants' ages ranged between 18 and 40 years. PCOS was diagnosed according to the Rotterdam criteria. LV strain (LS) and strain rate (SR) were evaluated using apical two-chamber (2C), three-chamber (3C), and four-chamber (4C) imaging. Global LS and SR were calculated as average of three apical views. The waist-to-hip ratio, homeostasis model assessment-insulin resistance (HOMA-IR), and fasting insulin and triglyceride levels were higher in the PCOS group than in the controls (p = 0.001, p = 0.001, p = 0.001, and p = 0.005, respectively). In the PCOS group, the mitral A wave, deceleration time (DT), and isovolumetric relaxation time (IVRT) were significantly higher than in the controls (all p < 0.05). The LV global longitudinal strain (GLS) and global longitudinal SR systolic (GLSRS) were significantly lower in the PCOS patient group (both p = 0.001). There were strong negative correlations between GLS and both fasting insulin (r = −0.64) and DT (r = -0.62) (both p < 0.05). The study demonstrated that PCOS patients had decreased LV function using STE. Therefore, STE imaging appears to be useful for the early detection of subclinical LV dysfunction in patients with PCOS.

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Section: Introductionmentioning

confidence: 99%

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Demirelli¹,

Değirmenci²,

Ermis³

et al. 2015

Biomol Biomed

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“…Other investigators, measuring ST globally, radially and circumferentially, showed a significant decreasing trend between the groups, with lower values of longitudinal strain in the CCM group compared with the control group (non‐ChD) in the midlateral, basal‐septal, basal‐anterior, and midanterior segments, and they found no differences in the longitudinal strain between the indeterminate patients and control group. Barbosa et al using a 2D longitudinal ST found a lower ST in the basal inferior, and inferoseptal walls, as well apical segment of the inferolateral wall compared to the control group . In contrast, we evidenced that GLS showed a significant decreasing trend across stages with an apparently sequential order in segmental wall impairment.…”

Section: Discussionmentioning

confidence: 92%

Echocardiographic parameters, speckle tracking, and brain natriuretic peptide levels as indicators of progression of indeterminate stage to Chagas cardiomyopathy

et al. 2020

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Background Chronic Chagas cardiomyopathy (CCM) is characterized by a unique type of cardiac involvement. Few studies have characterized echocardiographic (Echo) transitions from the indeterminate Chagas disease (ChD) form to CCM. The objective of this study was to identify the best cutoffs in multiple Echo parameters, speckle tracking, and N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) to distinguish patients without CCM (stage A) vs patients with myocardial involvement (stages B, C, or D). Methods Cross‐sectional study conducted in 273 consecutive patients with different CCM stages. Echo parameters, NT‐proBNP, and other clinical variables were measured. Logistic regression models (dichotomized in stage A versus B, C, and D) adjusted for age, sex, body mass index, and NT‐proBNP were performed. Results Left ventricular global longitudinal strain (LV‐GLS), mitral flow E velocity, LV mass index, and NT‐proBNP identified early changes that differentiated stages A vs B, C, and D. The LV‐GLS with a cutoff −20.5% showed the highest performance (AUC 92.99%; accuracy 84.56% and negative predictive value (NPV) 88.82%), which improved when it was additionally adjusted by NT‐proBNP with a cutoff −20.0% (AUC 94.30%; accuracy 88.42% and NPV 93.55%). Conclusions Our findings suggest that Echo parameters and NT‐proBNP may be used as diagnostic variables in detecting the onset of myocardial alterations in patients with the indeterminate stage of ChD. LV‐GLS was the more accurate measurement regarding stage A differentiation from the stages B, C, and D. Prospective longitudinal studies are needed to validate these findings.

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“…However, as this assessment relies on visual judgment, assessments of endocardial excursion are subjective and have a high interobserver variability. 25,[27][28][29][30] A recent study by Simsek et al 18 involving elite young athletes compared marathon runners and wrestlers. However, TDI is characterized with limitations in angle dependence, limited spatial resolution, and deformation analysis in 1 dimension.…”

Section: Discussionmentioning

confidence: 99%

“…This new technique enables a better evaluation of myocardial contraction and relaxation. 25,[27][28][29][30] A recent study by Simsek et al 18 involving elite young athletes compared marathon runners and wrestlers. While the systolic and diastolic functions evaluated by conventional echocardiography were similar, LV GLS strain and strain rate values were greater in both marathon runners and wrestlers than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Long‐Term Cardiac Remodeling in Elite Athletes: Assessment by Tissue Doppler and Speckle Tracking Echocardiography

et al. 2014

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Early Detection of Left Ventricular Contractility Abnormalities by Two‐Dimensional Speckle Tracking Strain in Chagas' Disease

Cited by 50 publications

References 32 publications

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Echocardiographic parameters, speckle tracking, and brain natriuretic peptide levels as indicators of progression of indeterminate stage to Chagas cardiomyopathy

Long‐Term Cardiac Remodeling in Elite Athletes: Assessment by Tissue Doppler and Speckle Tracking Echocardiography

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