Early detection of neonatal hearing loss by otoacoustic emissions and auditory brainstem response over 10 years of experience

Escobar-Ipuz, F.A.; Soria-Bretones, Carmen; García-Jiménez, María Ángeles; Cueto, Elisa; Aranda, Ana María Torres; Sotos, Jorge Mateo

doi:10.1016/j.ijporl.2019.109647

Cited by 20 publications

(14 citation statements)

References 18 publications

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“…This result supports published observations from a number of different countries such as United States [13], French Territories in Americas [11], or French Guiana [10], but it is much lower than the 42% observed in the Rio de Janeiro cohort [9]. Regarding audiological tests, 3.5% of children had abnormal results, which is a smaller proportion compared to the from a Brazilian cohort [21], but significant in relation to the results of a study in USA in which all ZIKV exposed infants of traveler pregnant women passed the test [22]. Moreover, this percentage is 7-fold higher compared to rates of hearing loss in the general child population of 5 per 1000 live births in Spain [23].…”

Section: Discussionmentioning

confidence: 68%

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

et al. 2020

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Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.

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Section: Discussionmentioning

confidence: 68%

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

et al. 2020

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“…Without appropriate stimuli reaching the auditory center of the brain, infants cannot achieve normal linguistic and social emotional development and later tend to experience psycholo gical and mental disorders 2,7) . Accordingly, it is critical that severe HL be detected in infants early on, especially premature infants.…”

Section: Introductionmentioning

confidence: 99%

“…Both are noninvasive and can easily be performed on neonates and infants 2,4,8) . Among the different screening pro tocols, ABR is the most objective confirmatory technique 7) .…”

Section: Introductionmentioning

confidence: 99%

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Hearing Impairments in Preterm Infants: Factors Associated with Discrepancies between Screening and Confirmatory Test Results

Han¹,

Shin²,

Lee³

et al. 2020

Neonatal Med

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Purpose: The aim of the study was to investigate risk factors of hearing impairments in preterm infants and analyze factors associated with discrepancies between neonatal hearing screening (NHS) and confirmatory test results. Methods: We analyzed the medical records of 352 preterm infants born at 23 to 32 weeks' gestational age (GA) who underwent both automated auditory brainstem response (aABR) and confirmatory ABR (cABR). Results: Mean GA, mean birth weight, the incidence of small for GA and cesarean section birth were significantly different between the pass and refer groups on aABR and the normal and abnormal groups of cABR. On univariate analysis, bronchopul monary dysplasia (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.00 to 7.48), intraventricular hemorrhage (OR, 7.02; 95% CI, 1.59 to 31.05), and use of furosemide (OR, 3.84; 95% CI, 1.38 to 10.73) were the factors related to refer results on aABR. Peri ventricular leukomalacia (PVL; OR, 4.00; 95% CI, 1.39 to 11.52) and use of vancomycin (OR, 2.86; 95% CI, 1.22 to 6.73) were associated with abnormal cABR. Twentyfive (7.9%) infants had discrepant aABR and cABR results, particularly males and those in whom vancomycin was used. Conclusion: PVL and use of vancomycin were confirmed as independent risk factors for hearing loss in infants born at less than 32 weeks' GA. Also, discrepancies between the screening and confirmatory test may occur, especially among male infants and those in whom vancomycin was used. The hearing of infants must be assessed more carefully in such groups regardless of NHS results.

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“…It can observe functional status of auditory nerve and lower auditory center, and reflect conduction ability of brainstem auditory pathway [1,2]. Given that patient's hearing impairment can be diagnosed without his active cooperation, ABR has become one of the routine methods for newborn hearing screening and adult hearing disease diagnosis [3,4,5]. ABR waveform usually has a short eclipse period of 10ms, and electrode intensity in microvolts is recorded.…”

Section: Introductionmentioning

confidence: 99%

Automatic Recognition of Auditory Brainstem Response Characteristic Waveform based on BiLSTM

Chen

Zhan

Pan

et al. 2020

Preprint

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BackgroundAuditory brainstem response (ABR) test is widely used in newborn hearing screening and hearing disease diagnosis. Identifying and marking are challenging and repetitive tasks because of complex rules of ABR characteristic waveform and interference of background noise.MethodsThis study proposes an automatic method to recognize ABR characteristic waveform. First, binarization is created to mark 1024 sampling points accordingly. The selected characteristic area of ABR data is 0-8ms. The marking area is enlarged to expand feature information and reduce marking error. Second, a bi-directional long short-term memory (BiLSTM) network structure is established to improve relevance of sampling points, and an ABR sampling point classifier is obtained by training. Finally, mark points are obtained through thresholding.ResultsSpecific structure, related parameters, recognition effect, and noise resistance of network were explored in 614 sets of ABR clinical data, and recognition accuracy of waves I, III, and V can reach 92.91%.DiscussionThus, the proposed method can reduce the repetitive work of doctors and meet accuracy effectively. Therefore, this method has clinical potential.

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Early detection of neonatal hearing loss by otoacoustic emissions and auditory brainstem response over 10 years of experience

Cited by 20 publications

References 18 publications

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain

Hearing Impairments in Preterm Infants: Factors Associated with Discrepancies between Screening and Confirmatory Test Results

Automatic Recognition of Auditory Brainstem Response Characteristic Waveform based on BiLSTM

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