Early Detection of Prostate Cancer by Routine Screening

Abstract

In an attempt to detect prostate cancer when the disease was still localized, a free screening clinic was established for men over the age of 45 years. Digital rectal examinations were performed for 811 men. Prostate biopsy was recommended to 43 in whom abnormalities were found by digital rectal examination; only 38 complied. Prostate cancer was detected in 11 men. The patients with cancer ranged in age from 60 to 79 years, with the highest incidence of cancer in the group aged 70 to 79 years. The overall incidence in men between 51 and 80 years old was 1.7%. Staging evaluation revealed that none of the patients with prostate cancer had metastases to the bone or elevated serum acid phosphatase levels. Five men (45%) were found by clinical or pathological methods to have stage B disease. Two others (18%) showed radiographic evidence of lymph node metastases (stage D1). The cost of detecting each cancerous prostate tumor was approximately +6,300. Routine screening can be a cost-effective method for diagnosing prostate cancer in patients with less extensive disease. The ability of early detection to prolong survival of patients with this disease will require further investigation.

Prostate-specific antigen coordinated with digital rectal examination and transrectal ultrasonography in the detection of prostate cancer

“…The detection rate of prostate cancer by DRE in a screening population is less than 2% [4][5][6]. This low rate is due principally to the subjectivity of the examination [7].…”

Computerized supported transrectal ultrasound (C-TRUS) in the diagnosis of prostate cancer

“…Da der Tastbefund und das PSA (insbesondere im sog. Graubereich von 4-0 ng/ml) allein nur eine geringe Spezifität besitzen, ist es für jede neue Untersuchungsmethode eine diagnostische Herausforderung, in dieser Gruppe die diagnostische Treffsicherheit zu erhöhen [24,26]. …”

The Value of Screening for Prostatic Carcinoma: A Commentary

“…The an swer is probably no. In one series, among 811 cases screened by rectal examination, only 5 were found to be confined to the prostate [28]. It has been estimated that it costs $ 6,300 for digital rectal examination to pick up one case of potentially curable carcinoma [ 13].…”

“…It has been estimated that it costs $ 6,300 for digital rectal examination to pick up one case of potentially curable carcinoma [ 13]. In similar studies involving 795 men screened by transrectal ultra sound, an average of 3% had localized carcinoma [11,[28][29][30]. The cost for this more expensive test would be six times as much.…”