Early detection of radiation-induced liver injury in rat by superparamagnetic iron oxide-enhanced MR imaging

Morimoto, Naoki; Ebara, Masaaki; Kato, Hirotoshi; Obata, Takayuki; Fujita, Jun–ichi; Kondo, Fukuo; Tsujii, Hirohiko; Saisho, Hiromitsu

doi:10.1002/(sici)1522-2586(199904)9:4<573::aid-jmri11>3.0.co;2-c

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…Uptake of SPIO was decreased in the acutely rejecting livers but was normal in the syngeneic transplantation model [44]. SPIO-enhanced MR imaging can detect the range and extent of liver injury a few days after irradiation [45]. However, it was also reported that the dose-dependency and rate of decay of efficacy of SPIO in cirrhosis were similar to those in normal liver [46,47].…”

Section: Liver and Spleen Imagingmentioning

confidence: 99%

Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging

2001

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Superparamagnetic iron oxide MR imaging contrast agents have been the subjects of extensive research over the past decade. The iron oxide particle size of these contrast agents varies widely, and influences their physicochemical and pharmacokinetic properties, and thus clinical application. Superparamagnetic agents enhance both T1 and T2/T2* relaxation. In most situations it is their significant capacity to reduce the T2/T2* relaxation time to be utilized. The T1 relaxivity can be improved (and the T2/T2* effect can be reduced) using small particles and T1-weighted imaging sequences. Large iron oxide particles are used for bowel contrast [AMI-121 (i.e. Lumirem and Gastromark) and OMP (i.e. Abdoscan), mean diameter no less than 300 nm] and liver/spleen imaging [AMI-25 (i.e. Endorem and Feridex IV, diameter 80-150 nm); SHU 555A (i.e. Resovist, mean diameter 60 nm)]. Smaller iron oxide particles are selected for lymph node imaging [AMI-227 (i.e. Sinerem and Combidex, diameter 20-40 nm)], bone marrow imaging (AMI-227), perfusion imaging [NC100150 (i.e. Clariscan, mean diameter 20 nm)] and MR angiography (NC100150). Even smaller monocrystalline iron oxide nanoparticles are under research for receptor-directed MR imaging and magnetically labeled cell probe MR imaging. Iron oxide particles for bowel contrast are coated with insoluble material, and all iron oxide particles for intravenous injection are biodegradable. Superparamagnetic agents open up an important field for research in MR imaging.

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Section: Liver and Spleen Imagingmentioning

confidence: 99%

Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging

2001

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“…Severely, well‐defined hypointense areas were only observed in rats administered SPIO and subsequently treated with hepatic irradiation; the administration of SPIO or hepatic irradiation alone did not produce them. Furthermore, the visualization of T2*‐hypointense irradiated areas are highly unlikely in rats treated with hepatic irradiation and subsequently administered SPIO (i.e., the reverse of our method), because previous studies have indicated that irradiated liver areas may show higher signals under this condition . They attributed the T2*‐high signals to radiation‐induced impairments in the phagocytotic functions of KCs to SPIO particles.…”

Section: Discussionmentioning

confidence: 98%

“…Furthermore, the visualization of T2*-hypointense irradiated areas are highly unlikely in rats treated with hepatic irradiation and subsequently administered SPIO (i.e., the reverse of our method), because previous studies have indicated that irradiated liver areas may show higher signals under this condition. 9,10 They attributed the T2*-high signals to radiationinduced impairments in the phagocytotic functions of KCs to SPIO particles. The high signals in irradiated liver parenchyma presumably hinder the detection of liver tumors with equivalent high signals on T2*-weighted images.…”

Section: Figure 3: a Waterfall Plot Showing Percent Increases In Tumorsmentioning

confidence: 99%

“…3,5,6 A clear and simultaneous visualization of the irradiated liver parenchyma and cancer lesions remains challenging with currently available imaging techniques, including contrast-enhanced computed tomography (CT) and MR imaging. [7][8][9][10][11][12][13] Radiationinduced changes in liver tissues hinder this visualization, particularly in acute and subacute phases after irradiation. Radiation-induced hyperemia, for instance, has been shown to frequently produce enhanced areas that are indiscernible from residual liver cancer lesions.…”

mentioning

confidence: 99%

“…There is an emerging need to explore this technique especially in stereotactic body radiotherapy (SBRT) for liver malignancies because liver motion due to respiration and cardiac pulsation may produce mis‐registration between the target volumes and actual irradiated areas . A clear and simultaneous visualization of the irradiated liver parenchyma and cancer lesions remains challenging with currently available imaging techniques, including contrast‐enhanced computed tomography (CT) and MR imaging . Radiation‐induced changes in liver tissues hinder this visualization, particularly in acute and subacute phases after irradiation.…”

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confidence: 99%

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Persistent T2*-hypointensity of the liver parenchyma after irradiation to the SPIO-accumulated liver: An imaging marker for responses to radiotherapy in hepatic malignancies

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Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation

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Nakagami

et al. 2014

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Early detection of radiation-induced liver injury in rat by superparamagnetic iron oxide-enhanced MR imaging

Cited by 9 publications

References 35 publications

Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging

Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging

Persistent T2*-hypointensity of the liver parenchyma after irradiation to the SPIO-accumulated liver: An imaging marker for responses to radiotherapy in hepatic malignancies

Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation

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