Early Detection of Rasmussen??s Syndrome by Brain SPECT Imaging

Burke, George; Fifer, S A; Yoder, James S.

doi:10.1097/00003072-199209000-00010

Cited by 21 publications

(12 citation statements)

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“…Only in a second phase, related to neuronal loss and gliosis, do macroscopic abnormalities appear with hemispheric atrophy seen with MRI [8,9]. In this phase there is well-preserved tissue with little neuronal loss, and MR images of the brain are frequently normal.…”

Section: Discussionmentioning

confidence: 99%

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Utility of Tc 99m HMPAO SPECT in the early diagnosis of Rasmussen’s syndrome

Paladin

Capovilla²,

Bonazza³

et al. 1998

Ital J Neuro Sci

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Neuroradiological examinations are important in the diagnosis of Rasmussen's syndrome (RS), but they frequently result normal in the early phase of the disease. We performed Tc 99m HMPAO SPECT (single photon emission computed tomography) on an 11-year, 5-month-old, right-handed girl, two months since the first seizure. SPECT showed a reduced uptake of HMPAO in the left temporal region despite normal results with magnetic resonance imaging (MRI). After six months, she developed epilepsia partialis continua, neurological signs appeared, and MRI showed cortical atrophy on the left side. SPECT seems to be a useful, inexpensive and diffuse technology able to give information in the early phases of RS useful in the prevention of serious consequences of the disease within a medical therapeutic program (ganciclovir or intravenous immunoglobulins).

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Section: Discussionmentioning

confidence: 99%

“…Several authors described a SPECT hypoperfusion in patients with RS [9,10], but only Burke and Fifer [9] performed this examination before MRI. The patient described presented right hemiparesis, expressive aphasia and epilepsia partialis continua when SPECT was performed.…”

Section: Discussionmentioning

confidence: 99%

Utility of Tc 99m HMPAO SPECT in the early diagnosis of Rasmussen’s syndrome

Paladin

Capovilla²,

Bonazza³

et al. 1998

Ital J Neuro Sci

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“…However, during the early stages of the disease, structural imaging results may be normal. In this situation, functional neuroimaging using SPECT or PET scanning can detect functional abnormalities (65,71,72).…”

Section: Rasmussen Encephalitis and Epilepsy Related To Suspected Infmentioning

confidence: 99%

The Role of Radionuclide Imaging in Epilepsy, Part 2: Epilepsy Syndromes

Kumar

Chugani

2017

J. Nucl. Med. Technol.

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CE credit: For CE credit, you can access the test for this article, as well as additional JNMT CE tests, online at https://www.snmmilearningcenter.org. Complete the test online no later than March 2020. Your online test will be scored immediately. You may make 3 attempts to pass the test and must answer 80% of the questions correctly to receive 1.0 CEH (Continuing Education Hour) credit. SNMMI members will have their CEH credit added to their VOICE transcript automatically; nonmembers will be able to print out a CE certificate upon successfully completing the test. The online test is free to SNMMI members; nonmembers must pay $15.00 by credit card when logging onto the website to take the test.PET and SPECT can play an important role in the evaluation of various epileptic syndromes, particularly those with unknown causes, by revealing various underlying abnormalities that may not be fully appreciated from MR imaging studies. In some cases, PET and SPECT provide crucial data that guide surgical resections of the epileptogenic zone for medically refractory epilepsy. In other cases, these neuroimaging modalities preclude a surgical option and can guide genetic studies. Longitudinal PET and SPECT studies may increase our understanding of the etiopathogenesis of epilepsy syndromes and provide a clearer picture of the natural history of neurologic progression.

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“…Magnetic resonance spectroscopy (MRS) can show neuronal cell loss or dysfunction even in areas that appear normal on MRI [22,23]. Tc-99m hexamthyl-propyleneamineoxime (HMPAO) single photon emission computed tomography (SPECT) or 18 2-fluor-2-deoxy-glucose (18-FDG) positron emission tomography (PET) shows hypometabolism or hypo perfusion in a more extensive distribution [24]. Serial SPECT and MRS imaging are more sensitive than MRI, and may help monitor progression or response to treatment [22,23,25].…”

Section: Laboratory Evaluationmentioning

confidence: 99%

Rasmussen’s encephalitis

Counce

Limdi

Kuzniecky

2001

Curr Treat Options Neurol

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When the diagnosis of Rasmussen's encephalitis is being considered, it is important to rapidly exclude other causes of epilepsia partialis continua and hemiparesis. Although there is no good data from randomized trials of different immune-related therapies, treatment with immunoglobulin G (IgG), steroids, or plasmapheresis is advocated as first-line therapy. It is not unreasonable to institute at least two treatment options (eg, IgG followed by plasmapheresis) if response to the first treatment is poor. Functional hemispherectomy and its variants are associated with a lower long-term complication rate.

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Early Detection of Rasmussen??s Syndrome by Brain SPECT Imaging

Cited by 21 publications

References 0 publications

Utility of Tc 99m HMPAO SPECT in the early diagnosis of Rasmussen’s syndrome

Utility of Tc 99m HMPAO SPECT in the early diagnosis of Rasmussen’s syndrome

The Role of Radionuclide Imaging in Epilepsy, Part 2: Epilepsy Syndromes

Rasmussen’s encephalitis

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