Early development of synchrony in cortical activations in the human

Koolen, Ninah; Dereymaeker, A; Räsänen, Okko; Jansen, Katrien; Vervisch, Jan; Matić, Vladimir; Naulaers, Gunnar; Vos, Maarten De; Huffel, Sabine Van; Vanhatalo, Sampsa

doi:10.1016/j.neuroscience.2016.02.017

Cited by 32 publications

(39 citation statements)

References 40 publications

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“…A normal background developmental transition from desynchronized to synchronized activity may also explain the increasing baseline ECoG energy with age observed here. In human infants synchrony between cortical activations also increases with age in the last 2 months before term (Koolen et al 2016). However, skin injury also causes a transient but significant decrease in theta energy that is evident at all ages from P14 to P30 that cannot be explained by residual isoflurane from the surgery (MacIver and Bland 2014).…”

Section: Discussionmentioning

confidence: 99%

The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups

et al. 2016

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Cortical perception of noxious stimulation is an essential component of pain experience but it is not known how cortical nociceptive activity emerges during brain development. Here we use continuous telemetric electrocorticogram (ECoG) recording from the primary somatosensory cortex (S1) of awake active rat pups to map functional nociceptive processing in the developing brain over the first 4 weeks of life. Cross-sectional and longitudinal recordings show that baseline S1 ECoG energy increases steadily with age, with a distinctive beta component replaced by a distinctive theta component in week 3. Event-related potentials were evoked by brief noxious hindpaw skin stimulation at all ages tested, confirming the presence of functional nociceptive spinothalamic inputs in S1. However, hindpaw incision, which increases pain sensitivity at all ages, did not increase S1 ECoG energy until week 3. A significant increase in gamma (20–50 Hz) energy occurred in the presence of skin incision at week 3 accompanied by a longer-lasting increase in theta (4–8 Hz) energy at week 4. Continuous ECoG recording demonstrates specific postnatal functional stages in the maturation of S1 cortical nociception. Somatosensory cortical coding of an ongoing pain “state” in awake rat pups becomes apparent between 2 and 4 weeks of age.

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Section: Discussionmentioning

confidence: 99%

The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups

et al. 2016

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“…EEG recordings were obtained in 20 preterm infants between 30 and 44 weeks postmenstrual age and revealed strong increases in interhemispheric synchrony and less pronounced increases in intrahemispheric connectivity. In addition, anterior brain regions showed stronger synchrony compared with posterior brain regions and most subjects displayed higher correlations within the left hemisphere than the right, suggesting an anteroposterior maturation gradient and early left lateralization (Koolen et al, 2016).…”

Section: Preterm Birthmentioning

confidence: 92%

The emergence of functional architecture during early brain development

2017

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Early human brain development constitutes a sequence of intricate processes resulting in the ontogeny of functionally operative neural circuits. Developmental trajectories of early brain network formation are genetically programmed and can be modified by epigenetic and environmental influences. Such alterations may exert profound effects on neurodevelopment, potentially persisting throughout the lifespan. This review focuses on the critical period of fetal and early postnatal brain development. Here we collate findings from neuroimaging studies, with a particular focus on functional MRI research that interrogated early brain network development in both health and high-risk or disease states. First, we will provide an overview of the developmental processes that take place from the embryonic period through early infancy in order to contextualize brain network formation. Second, functional brain network development in the typically developing brain will be discussed. Third, we will touch on prenatal and perinatal risk factors that may interfere with the trajectories of functional brain wiring, including prenatal substance exposure, maternal mental illness and preterm

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“…Serial electro-encephalography (EEG) monitoring over time can document actual normal or altered brain function and provides insight into the progress of brain maturation during this period of intensive neonatal care [1,4,5], with the ultimate goal to improve therapeutic interventions and long-term neurodevelopmental outcome.…”

Section: Introductionmentioning

confidence: 99%

Review of sleep-EEG in preterm and term neonates

Dereymaeker

Pillay

Vervisch

et al. 2017

Early Human Development

108

117

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Neonatal sleep is a crucial state that involves endogenous driven brain activity, important for neuronal survival and guidance of brain networks. Sequential EEG-sleep analysis in preterm infants provides insights into functional brain integrity and can document deviations of the biologically pre-programmed process of sleep ontogenesis during the neonatal period. Visual assessment of neonatal sleep-EEG, with integration of both cerebral and non-cerebral measures to better define neonatal state, is still considered the gold standard. Electrographic patterns evolve over time and are gradually time locked with behavioural characteristics which allow classification of quiet sleep and active sleep periods during the last 10weeks of gestation. Near term age, the neonate expresses a short ultradian sleep cycle, with two distinct active and quiet sleep, as well as brief periods of transitional or indeterminate sleep. Qualitative assessment of neonatal sleep is however challenged by biological and environmental variables that influence the expression of EEG-sleep patterns and sleep organization. Developing normative EEG-sleep data with the aid of automated analytic methods, can further improve our understanding of extra-uterine brain development and state organization under stressful or pathological conditions. Based on those developmental biomarkers of normal and abnormal brain function, research can be conducted to support and optimise sleep in the NICU, with the ultimate goal to improve therapeutic interventions and neurodevelopmental outcome.

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Early development of synchrony in cortical activations in the human

Cited by 32 publications

References 40 publications

The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups

The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups

The emergence of functional architecture during early brain development

Review of sleep-EEG in preterm and term neonates

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