Early Development of the Vertebrate Inner Ear

Magariños, Marta; Contreras, Julio; Aburto, María Rodríguez; Varela-Nieto, Isabel

doi:10.1002/ar.22575

Cited by 38 publications

(32 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the cochlea, in the scala media , more than a dozen interconnected cell types are fundamental for hearing. The auditory sensory epithelium, the organ of Corti, contains two types of hair cells, outer and inner, innervated by the spiral ganglion neurons that connect it with the brain (Magariños et al, 2012, 2014). The irreversible loss of hair cells and/or neurons, or their malfunctions are the typical causes of sensorineural HL (SNHL).…”

Section: Hearing Lossmentioning

confidence: 99%

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Partearroyo

Vallecillo

Pajares

et al. 2017

Front. Mol. Neurosci.

Self Cite

View full text Add to dashboard Cite

Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic substances and aging playing a role. The nutritional status is central in aging disability, but the interplay between nutrition and SNHL has only recently gained attention. Dietary supplementation could therefore constitute the first step for the prevention and potential repair of hearing damage before it reaches irreversibility. In this context, different epidemiological studies have shown correlations among the nutritional condition, increased total plasma homocysteine (tHcy) and SNHL. Several human genetic rare diseases are also associated with homocysteine (Hcy) metabolism and SNHL confirming this potential link. Accordingly, rodent experimental models have provided the molecular basis to understand the observed effects. Thus, increased tHcy levels and vitamin deficiencies, such as folic acid (FA), have been linked with SNHL, whereas long-term dietary supplementation with omega-3 fatty acids improved Hcy metabolism, cell survival and hearing acuity. Furthermore, pharmacological supplementations with the anti-oxidant fumaric acid that targets Hcy metabolism also improved SNHL. Overall these results strongly suggest that cochlear Hcy metabolism is a key player in the onset and progression of SNHL, opening the way for the design of prospective nutritional therapies.

show abstract

Section: Hearing Lossmentioning

confidence: 99%

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Partearroyo

Vallecillo

Pajares

et al. 2017

Front. Mol. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Scale bars: (a) 0.5 mm; (b–e) 50 μm. Co, cochlea; V, vestibule; Asc, Lsc and Psc, anterior, lateral and posterior semicircular canals; Do, dorsal; Cd, caudal; IHC, inner hair cells; OHC, outer hair cells; StV, stria vasculari; SpL, spiral ligament; SV, scala vestibule; SM, scala media; ST, scala tympani; LW, lateral wall; OC, Organ of Corti (adapted from Magariños et al, 2014). …”

Section: An Introduction To Autophagymentioning

confidence: 99%

“…The auditory and vestibular organs contain the mechanosensory receptors that transduce mechanical stimuli into electrochemical signals that are transmitted to the brain by the fibers of the VIIIth cranial nerve. The auditory receptor is the organ of Corti in the scala media of the cochlea (Magariños et al, 2012, 2014), which is formed by sensory hair cells and by non-sensory support cells (Deiters', Hensen's and Claudius') that maintain the ionic and metabolic cochlear homeostasis (Forge and Wright, 2002). There are two functional types of hair cells arranged in a stereotypic manner: one row of inner hair cells (IHC) and three rows of outer hair cells (OHC; Forge and Wright, 2002; Magariños et al, 2012).…”

Section: An Introduction To Inner Ear Anatomymentioning

confidence: 99%

“…The auditory receptor is the organ of Corti in the scala media of the cochlea (Magariños et al, 2012, 2014), which is formed by sensory hair cells and by non-sensory support cells (Deiters', Hensen's and Claudius') that maintain the ionic and metabolic cochlear homeostasis (Forge and Wright, 2002). There are two functional types of hair cells arranged in a stereotypic manner: one row of inner hair cells (IHC) and three rows of outer hair cells (OHC; Forge and Wright, 2002; Magariños et al, 2012). The IHC cells connect to bipolar auditory type I neurons of the spiral ganglion, whilst the OHC are innervated by type II neurons (Nayagam et al, 2011; Fritzsch et al, 2015).…”

Section: An Introduction To Inner Ear Anatomymentioning

confidence: 99%

See 1 more Smart Citation

Autophagy in the Vertebrate Inner Ear

Magariños

Pulido

Aburto

et al. 2017

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

Autophagy is a conserved catabolic process that results in the lysosomal degradation of cell components. During development, autophagy is associated with tissue and organ remodeling, and under physiological conditions it is tightly regulated as it plays a housekeeping role in removing misfolded proteins and damaged organelles. The vertebrate inner ear is a complex sensory organ responsible for the perception of sound and for balance. Cell survival, death and proliferation, as well as cell fate specification and differentiation, are processes that are strictly coordinated during the development of the inner ear in order to generate the more than a dozen specialized cell types that constitute this structure. Here, we review the existing evidence that implicates autophagy in the generation of the vertebrate inner ear. At early stages of chicken otic development, inhibiting autophagy impairs neurogenesis and causes aberrant otocyst morphogenesis. Autophagy provides energy for the clearing of dying cells and it favors neuronal differentiation. Moreover, autophagy is required for proper vestibular development in the mouse inner ear. The autophagy-related genes Becn1, Atg4g, Atg5, and Atg9, are expressed in the inner ear from late developmental stages to adulthood, and Atg4b mutants show impaired vestibular behavior associated to defects in otoconial biogenesis that are also common to Atg5 mutants. Autophagic flux appears to be age-regulated, augmenting from perinatal stages to young adulthood in mice. This up-regulation is concomitant with the functional maturation of the hearing receptor. Hence, autophagy can be considered an intracellular pathway fundamental for in vertebrate inner ear development and maturation.

show abstract

“…The efferent response is also altered in the senescent gerbil, indeed vestibular and cochlear efferent neurons are differentially modified (Radtke-Schuller et al, 2015). Auditory and vestibular organs have a common developmental origin (Magariños et al, 2012) and the parallel and gradual deterioration of both is strongly associated with aging. Older human adults showing hearing loss generally have increased audiometric thresholds.…”

mentioning

confidence: 99%

Aging, neurogenesis and neuroinflammation in hearing loss and protection

2015

Frontiers Research Topics

View full text Add to dashboard Cite

Early Development of the Vertebrate Inner Ear

Cited by 38 publications

References 172 publications

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Autophagy in the Vertebrate Inner Ear

Aging, neurogenesis and neuroinflammation in hearing loss and protection

Contact Info

Product

Resources

About