Early development of vaginal shortening during radiation therapy for endometrial or cervical cancer

Katz, Angela; Njuguna, Esther; Rakowsky, Erica; Sulkes, Aarón; Sulkes, Jaqueline; Fenig, Eyal

doi:10.1046/j.1525-1438.2001.01019.x

Cited by 49 publications

(30 citation statements)

References 6 publications

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“…A significant difference in vaginal length occurred between the first and second treatment for patients treated with external beam and brachytherapy but not with brachytherapy alone. 26 Our results revealed similarly reported outcomes between the 2 groups in all areas of QOL, including sexual functioning. However, both groups report sexual and vaginal changes; and many patients in both groups were not sexually active.…”

Section: Discussionsupporting

confidence: 83%

Sexual Function After Intracavitary Vaginal Brachytherapy for Early-Stage Endometrial Carcinoma

Quick

Seamon

Abdel-Rasoul

et al. 2012

International Journal of Gynecological Cancer

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Objective To describe the effects of intracavitary brachytherapy (IVB) on sexual function and quality of life of women with early-stage endometrial cancer. Methods Women with International Federation of Gynecology and Obstetrics stage I to stage II endometrial cancer treated surgically with or without IVB were identified and mailed questionnaires. Quality of life and sexual function were measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the cervical cancer disease-specific module. Pertinent data from prior surgery and radiation treatments were abstracted retrospectively. Linear transformation of the survey subscale scores was conducted per European Organization for Research and Treatment of Cancer guidelines. Results Sixteen women in the IVB arm and 53 in the surgery-alone group completed the survey. Of the sexually active patients, 33% of the IVB patients and 42% of the surgery-alone patients felt their vagina was dry during sexual activity (P = 0.804) and 17% versus 20% felt their vagina was short (P = 0.884). Seventeen percent of patients in the IVB group felt their vagina was tight compared to 29% in the surgery-alone group (P = 0.891) and 0% versus 14% of patients reported pain during intercourse (P = 0.808). There was no statistically significant difference in sexual/vaginal functioning, sexual worry, or sexual enjoyment between the 2 groups. Conclusions Although both groups report vaginal changes that may affect sexual function, the patients treated with IVB reported similar outcomes on a sexual function questionnaire compared to patients treated with surgery alone.

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Section: Discussionsupporting

confidence: 83%

Sexual Function After Intracavitary Vaginal Brachytherapy for Early-Stage Endometrial Carcinoma

Quick

Seamon

Abdel-Rasoul

et al. 2012

International Journal of Gynecological Cancer

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“…The decrease in vaginal length may explain in part the increased dyspareunia. Vaginal shortening can occur during the course of intracavity and external irradiation (27)(28)(29). In the present study the vaginal length was smaller in patients submitted to CT/RT or RT when compared to the RH group.…”

Section: Discussionsupporting

confidence: 46%

Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions?

et al. 2013

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Aims: Describe the impact of surgery, radiotherapy and chemoradiation in the pelvic floor functions in cervical cancer patients. Materials and Methods: A prospective study with women submitted to radical hysterectomy (RH) (n = 20), exclusive radiotherapy (RT) (n = 20) or chemoradiation (CT/RT) (n = 20) for invasive cervical cancer. Urinary, intestinal and sexual function, as well as vaginal length and pelvic floor muscle contraction were evaluated. Comparisons between groups were performed by Kruskal-Wallis and Chi-square tests (p < 0.05). Results: The groups were similar in stress urinary incontinence incidence (p = 0.56), urinary urgency (p = 0.44), urge incontinence (p = 0.54), nocturia (p = 0.53), incomplete bowel emptying (p = 0.76), bowel urgency (p = 0.12) and soilage (p = 0.43). The CT/ RT group presented a higher urinary frequency (p < 0.001) and diarrhea (p = 0.025). Patients in the RH group were more sexually active (p = 0.01) and experienced less dyspareunia (p = 0.021). Vaginal length was shorter in RT group (5.5 ± 1.9 cm) and CT/ RT(5.3 ± 1.5 cm) than in the RH group (7.4 ± 1.1 cm) (p < 0.001). Pelvic floor muscle contraction was similar (p = 0.302). Conclusions: RT and CT/RT treatment for cervical carcinoma are more associated to sexual and intestinal dysfunctions.

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“…The PORTEC-2 trial showed that only 15% of the patients were sexually active after surgery, this increased significantly to 39% during the first year and sexual functioning and symptoms did not differ between vaginal BRT and EBRT at a median follow up of 2 years 15. Several large studies have shown that a large proportion of patients with endometrial cancer have sexual dysfunctions after vaginal BRT 16,17. However, in a prospective study by Quick et al, vaginal BRT patients had sexual functions similar to women treated with surgery alone 15,18.…”

mentioning

confidence: 99%

Assessing the Quality of Life in Patients With Endometrial Cancer Treated With Adjuvant Radiotherapy

Karabuga

Gültekin

Tulunay

et al. 2015

International Journal of Gynecological Cancer

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Early development of vaginal shortening during radiation therapy for endometrial or cervical cancer

Cited by 49 publications

References 6 publications

Sexual Function After Intracavitary Vaginal Brachytherapy for Early-Stage Endometrial Carcinoma

Sexual Function After Intracavitary Vaginal Brachytherapy for Early-Stage Endometrial Carcinoma

Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions?

Assessing the Quality of Life in Patients With Endometrial Cancer Treated With Adjuvant Radiotherapy

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