Early developmental outcome following surgery for oesophageal atresia

Abstract

This study found a lower than expected developmental score for infants following surgery for OA/TOF in the expressive language subscale compared with the healthy control infants. These findings support concerns over the potential impact of OA/TOF and its effects on development. Further studies, including continuing developmental review to determine whether these differences persist and their functional importance, should be performed.

Growth and development after oesophageal atresia surgery: Need for long-term multidisciplinary follow-up

“…The scarce data on neurodevelopmental outcome in OA-patients are summarized for different age categories in Table 1 scores for non-syndromal OA-patients generally were within the normal ranges (20)(21)(22). In the study by Walker and co-workers, however, the mean score on language expression at one year was significantly below the norm (21).…”

Neurodevelopmental Outcomes After Neonatal Surgery for Major Noncardiac Anomalies

“…After screening of title/abstract followed by full text, 23 papers 6,7,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] reporting on 895 children met our inclusion and exclusion criteria and were selected for systematic review (Table 1). There was a wide range in follow-up duration and time of assessment from 12 months up to 60 months of age.…”

“…6,7,25,26,28,29,31,[36][37][38][39][40][41] This metaanalysis in 511 children resulted in a motor development score of 0.6 SD below the population average, indicated by the PDI score of 91 ± 14 (Fig 3A). One-sample t tests demonstrated that the mean PDI was significantly lower than the healthy population mean of 100 (P < .001; 95% CI 89.8-92.1).…”

“…Meta-analysis in 498 infants showed a cognitive development score of 0.5 SD below the population reference mean, expressed as MDI score of 92 ± 13 (mean ± SD) 6,7,25,26,28,29,31,[36][37][38]40,41 (Fig 2A), with data from BSID-II and -III at 12 and 24 months of age. Onesample t tests demonstrated that the mean MDI was significantly lower than the healthy population mean of 100 (P < .001; 95%, confidence interval [CI] 91.7-94.2).…”

“…Three articles 25,29,36 reported solely on infants with esophageal atresia and their short-term neurodevelopmental outcome at 1 year of age. By systematically reviewing these articles, a delay was reported in 11% to 38%.…”