Early developmental outcome of infants with infantile hypertrophic pyloric stenosis

Walker, Karen; Halliday, Robert; Holland, A.J.A.; Karskens, Caroline; Badawi, Nadia

doi:10.1016/j.jpedsurg.2010.08.035

Cited by 51 publications

(46 citation statements)

References 27 publications

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“…The precise role of anesthesia in these complex cases is very difficult to tease out from among the multitude of variables. Neonatologists have also reported that undergoing even a minor surgical procedure increases the risk of a poor neurobehavioral outcome in otherwise healthy children [36,37].…”

Section: Clinical Evidencementioning

confidence: 99%

Anesthesia and Apoptosis in the Developing Brain: An Update

Davidson

deGraaff

2012

Curr Anesthesiol Rep

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There is an increasing concern regarding the risk of anaesthetic neurotoxicity in children. Numerous animal and in vitro studies have demonstrated that general anaesthetics cause a variety of potentially harmful effects on the developing brain. An increased level of neuronal apoptosis is one such effect. In some studies, exposed animals have experienced long-lasting neurobehavioural changes. These effects occur at very specific stages of development and are dose-dependent. There are several plausible mechanisms for these deleterious effects; however, the exact mechanism remains unclear. Most importantly, histological and behavioral effects have been demonstrated in non-human primates. Human research evaluating the long-term effects of anaesthesia on brain development is limited and, to date, has been limited to retrospective observational cohort studies. The results of these studies have not been consistent, with some demonstrating an association between surgery and adverse neurobehavioral outcome and others showing no association. Furthermore, these cohort studies have numerous weaknesses and limitations. An ongoing randomized clinical trial aims to provide clear evidence regarding the clinical safety of anesthetics up to 1 h in neonates and older children.

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Section: Clinical Evidencementioning

confidence: 99%

Anesthesia and Apoptosis in the Developing Brain: An Update

Davidson

deGraaff

2012

Curr Anesthesiol Rep

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“…Thereby other variables must be taken into account. Neonatologists have also reported similar findings [9].…”

Section: Clinical Evidence On Humansmentioning

confidence: 54%

Effects of Anesthesia on Children’s Brain Development

Hernández-Cortez

2015

JACCOA

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“…Of the 13 studies reviewed, only one is prospective [36][37][38][39][40][41][42][43][44][45][46][47][48][49] (Table 2). Walker et al [48] in a negative study examined the developmental outcome in prospectively enrolled infants who underwent pyloromyotomy for pyloric stenosis with followup limited to 1 year.…”

Section: Methodsmentioning

confidence: 99%