Early diagnosis and prompt treatment by surgery in Jorge Lobo's disease (Keloidal blastomycosis)

Baruzzi, Roberto Geraldo; Marcopito, Luiz Francisco; Michalany, N. S.; Livianu, J.; Pinto, Nigel

doi:10.1007/bf00441441

Cited by 22 publications

(13 citation statements)

References 2 publications

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“…8 Favorable results after surgical excision or cryosurgery have been obtained in early and small well-circumscribed lesions, but relapses at the margin of the excision may still occur. 9,10 Posaconazole is a new triazole that has demonstrated efficacy in the treatment of subcutaneous diseases caused by Madurella grisea, Madurella mycetomatis, Scedosporium apiospermium, and Fonsecaea pedrosoi refractory to standard therapy. 11 This antifungal agent appears to be safe and well tolerated when prescribed for prolonged periods ( 6 months) for treatment of subacute or chronic fungal infections.…”

Section: Discussionmentioning

confidence: 99%

Lobomycosis Successfully Treated with Posaconazole

Bustamante

Seas²,

Salomón³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Lobomycosis is a chronic subcutaneous mycosis for which no standard treatment is available to date. We describe a patient in Peru with lobomycosis on the left earlobe that was successfully treated with posaconazole for 27 months. No evidence of recurrence was observed after five years of follow-up.Lobomycosis (lacaziosis) is a chronic subcutaneous disease caused by the fungus Lacazia loboi, which is reported mainly in Central and South America, mostly from Brazil and Colombia.

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Section: Discussionmentioning

confidence: 99%

Lobomycosis Successfully Treated with Posaconazole

Bustamante

Seas²,

Salomón³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…1,3,5 The human disease appears to be endemic in Central and Western Brazil, Bolivia, Colombia, Costa Rica, Ecuador, Guyana, Mexico, Panama, Peru, Suriname and Venezuela. [1][2][3][4][5][6]8,11,13,21 However, there have been isolated cases in the United States, 22 Canada, 16 Africa, 23 the Netherlands, 24 France 25 and Germany. 15 More than 550 human cases have been reported to date, especially in patients with a history of travel or residence in the areas of endemicity or in communities along rivers.…”

Section: 241819mentioning

confidence: 99%

“…1,2 Transformation of an old lesion to squamous cell carcinoma has been described. 12 As the organism has not yet been cultured, the diagnosis is based upon the macro-and microscopic examination of the lesions, 1,2,5,13,14 demonstrating the presence of round or oval, thick walled yeast-like cells ranging from 5 to 12 μm diameter in lesions exudate or tissue sections. 1,2,13,14 The organism multiplies by budding, and thus mother cells with single buds are often observed.…”

Section: Introductionmentioning

confidence: 99%

“…12 As the organism has not yet been cultured, the diagnosis is based upon the macro-and microscopic examination of the lesions, 1,2,5,13,14 demonstrating the presence of round or oval, thick walled yeast-like cells ranging from 5 to 12 μm diameter in lesions exudate or tissue sections. 1,2,13,14 The organism multiplies by budding, and thus mother cells with single buds are often observed. 1,2 Characteristic sequential budding leads to the production of cell chains linked to each other by a tubular connection.…”

Section: Introductionmentioning

confidence: 99%

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Lobomycosis: A case from Southeastern Europe and review of the literature

Papadavid¹,

Dalamaga²,

Kapniari³

et al. 2012

J Dermatol Case Rep

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Background: Lobomycosis, also known as Jorge Lobo's disease, represents a rare chronic subcutaneous mycosis caused by the fungus Lacazia loboi, an organism that is found within lesions but has not been cultured to date. The natural reservoir of L. loboi is unknown but it is believed to be aquatic, or associated with soil and vegetation. More than 550 human cases have been reported, especially in patients with a history of travel or residence in endemic areas (Central and South America, particularly Brazil) or in communities along rivers. Main observations:We describe a 64-year-old Greek female farmer living in a coastal region, who presented with an erythematous plaque on her left inner thigh resembling a keloid. The diagnosis was based on the triad: 1) absence of fungal growth in cultures, 2) positive direct microscopic examination of the lesion and 3) histopathology, all consistent with lobomycosis. Particularly, skin biopsy showed deep cutaneous fungal infection with granulomatous reaction. Fungal cells were found inside giant cells. The fungi were thick-walled with some budding, isolated or in short chains. Dermal fibrosis was present. Our patient had a medical history of common variable immunodeficiency but no history of travel to South or Central America. She probably acquired this rare infection by injury during her agricultural works. Conclusion:Our case represents probably the first documented case of human lobomycosis in Southeastern Europe. This case is unusual due to the rarity of lobomycosis in Mediterranean countries, particularly in Southeastern Europe. (J Dermatol Case Rep. 2012; 6(3): 65-69)

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“…La enfermedad predomina en la Amazonia y es interesante que de los 267 casos descritos, cincuenta y siete (21%) lo fueron en indígenas de la Tribu Caibai en el Brasil central (19,25), cuya población es hoy apenas de 300 miembros. Díaz y col. en 1970, sitúan 69 casos en la Amazonia brasileña (22).…”

Section: Epidemiologiaunclassified

Enfermedad de Jorge Lobo o Blastomicosis queloidiana. Nuevos aspectos de la entidad en Colombia. Revisión

Toro¹

1989

biomedica

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Revisamos además ocho pacientes remitidos por colegas o presentados en congresos nacionales de dermatología, con lo cual el número de colombianos con lobomicosis es de 25, la tercera frecuencia despúes del Brasil y de Surinam. La Orinoquia y la Amazonia en pacientes indígenas y la Costa Pacífica en* la raza negra, son las áreas en las que predomina la lobomicosis. La complicación más frecuente es la ulceración que la hace confundir con leishmaniasis. En u n indígena se desarrolló u n carcinoma escamocelular sobre su lesión de lobomicosis, de dos años de evolución, que curó con la resección quirúrgica. Se ilustran aspectos macro y microscópicos d e la entidad.1. DEFINICION 2. SINONIMIA Enfermedad crónica de la piel, caracterizada por Lobomicosis, blastomicosis queloidiforme, blastonódulos y placas que corresponden a granulomas dér-micosis queloidea, granuloma blastomicoide, granumicos en los cuales abunda el Paracoccidioides loboi, loma micótico de Lobo, falsa lepra, blastomicosis agente etiológico de la entidad.amazónica.

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Early diagnosis and prompt treatment by surgery in Jorge Lobo's disease (Keloidal blastomycosis)

Cited by 22 publications

References 2 publications

Lobomycosis Successfully Treated with Posaconazole

Lobomycosis Successfully Treated with Posaconazole

Lobomycosis: A case from Southeastern Europe and review of the literature

Enfermedad de Jorge Lobo o Blastomicosis queloidiana. Nuevos aspectos de la entidad en Colombia. Revisión

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