Early Diagnosis of Acute Myeloid Leukemia by Computed Tomography Scan

Rassi, Fuad El; Little, Brent P.; Holloway, Stacie; Roberts, David A.; Khoury, H. Jean

doi:10.1200/jco.2011.41.0506

Cited by 4 publications

(3 citation statements)

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“…Although characteristic imaging findings of bone marrow infiltration by malignant cells have been extensively studied on magnetic resonance imaging (MRI) (7–11), there have been few reports of CT findings of bone marrow infiltration in patients with AML. Although bone marrow CT attenuation has been known to sometimes increase in patients with myeloproliferative disorders, there has only been one case report that described increased bone marrow CT attenuation in a patient with AML (12). No previous reports have described the actual threshold of the CT attenuation value predictive of AML.…”

Section: Discussionmentioning

confidence: 99%

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A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia

et al. 2022

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Background Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Bone marrow computed tomography (CT) attenuation may increase in patients with myeloproliferative disorders; however, the actual threshold CT attenuation value predictive of myeloproliferative has not been reported. Purpose To determine whether the unenhanced CT attenuation value of the bone marrow may be useful for predicting AML. Material and Methods We retrospectively analyzed patients with AML (n = 56) who underwent unenhanced CT before treatment, and age- and sex-matched controls without any hematologic disease. For each patient, the CT attenuation value (HU) of the iliac bone was measured and compared between the two groups. Receiver operating characteristic (ROC) curve analysis was used to define the cutoff value for predicting AML on all patients, and only on late elderly patients (aged ≥75 years). Results Patients with AML showed higher bone marrow CT attenuation value (131.4 ± 58.3 vs. 53.9 ± 67.2 HU; P < 0.001), compared to the controls. The sensitivity and specificity for the diagnosis of AML in all patients were 78.6% and 80.4%, respectively, at a threshold value of 90 HU, whereas they were 83.3% and 91.7%, respectively, at 40 HU in late elderly patients. Conclusion The iliac bone CT attenuation value was elevated in patients with AML and may be useful for predicting AML.

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Section: Discussionmentioning

confidence: 99%

“…However, in the presence of abnormally high bone marrow density in unenhanced body CT, radiologists can suggest the possibility of AML. This may be particularly important because the elevation of bone marrow density may occur before the appearance of blood abnormalities and any symptoms related to AML (12).…”

Section: Discussionmentioning

confidence: 99%

A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia

et al. 2022

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“…However, magnetic resonance imaging (MRI) has found that abnormal bone marrow signals appear in patients who have not been previously diagnosed with leukemia.The differentiation between benign marrow edema and tumorous involvement of the bone marrow is the measurement of the tissue microstructure the diffusion-weighted imaging reflects the random motion of water protons. MRI enables precise assessment of bone marrow infiltration early and before osteolytic changes become visible by conventional radiology imaging or CT scans [54].…”

Section: Magnetic Resonance Imaging (Mri) Scanmentioning

confidence: 99%

Adult Acute Myeloid Leukemia – A Possible Relation to Disease Invasion and the Impact of Independent Prognostic Markers Associated with Survival Outcome

Elrefaei¹,

Qahtani²

2016

New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis

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Over the past decade, leukemia exists and frequently occurs in adults. Radiation exposure, hereditary syndromes, smoking, age, and many other unknown factors are generally the major risk factors for leukemia. "cute myeloid leukemia "ML is a hematological malignancy that is dispersed from its beginning and may be perceived as a prototype of metastatic cancer, yet leukemia is considered a highly malignant neoplasms responsible for a large number of cancer-related deaths. In addition, to uninhibited proliferation, leukemic cells dispense early from the bone marrow into the peripheral blood, followed by an infiltration of various organs such as lymph nodes, liver, spleen, lungs, intestinal tract, skin, or mucous membranes. †everal studies are concerned with the critical role of angiogenesis in the development and growth of solid tumors and hematological malignancies. Moreover, angiogenic mediators created by "ML cells act through external or internal autocrine loops, thereby directly indorsing cell survival, spread, and disease development. In recent years, many researchers focus on angiopioetins "ng , an innovative family of angiogenic mediators, which have shown to be vital regulators of angiogenesis and vascular stability. "ng-and its antagonist "ng-act via the receptor tyrosine kinase s ‡ie , which is expressed in endothelial cells ECs of the vasculature and in subset of hematopoietic stem cells. "inding of "ng-causes phosphorylation of s ‡ie and ensures the integrity of the vasculature by stimulating interactions between ECs and endothelial support cells. ‡his chapter reviews the incidence, mortality, pathogenesis, and diagnostic procedures of "ML. "s well as aims at evaluating serum levels of endostatin, MMP-, and uP"R in acute myeloid leukemia patients before chemotherapy and after achieving complete remission. "t the same time, the chapter also assesses the pretreatment levels of plasma "ng-, "ng-, and s ‡ie , and the calculated ratio of "ng /s ‡ie receptor in a cohort of "ML patients also studies their impact on the "ML patients' overall survival.

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Bevacizumab treatment of prostate cancer

Small¹,

Oh²

2012

Expert Opinion on Biological Therapy

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Early Diagnosis of Acute Myeloid Leukemia by Computed Tomography Scan

Cited by 4 publications

References 4 publications

A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia

A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia

Adult Acute Myeloid Leukemia – A Possible Relation to Disease Invasion and the Impact of Independent Prognostic Markers Associated with Survival Outcome

Bevacizumab treatment of prostate cancer

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